Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3668-3678

  Von Geldern, Thomas W ^a   Tasker, Andrew S ^a,b   Sorensen, Bryan K ^a   Winn, Martin ^a   Szczepankiewicz, Bruce G ^a   Dixon, Douglas B ^a   Chiou, William J ^a   Wang, Liming ^a   Wessale, Jerry L ^a   Adler, Andy ^a   Marsh, Kennan C ^a   Nguyen, Bach ^a   Opgenorth, Terry J ^a  

^a ABBOTT LABORATORIES   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ATRASENTAN; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; PYRROLIDINE 3 CARBOXYLIC ACID DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE REGULATION; CHO CELL; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENANTIOMER; NONHUMAN; RAT; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ACETANILIDES; ANIMALS; BLOOD PRESSURE; CELL LINE; ENDOTHELIN-1; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN;

EID: 0033539145     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990170q     Document Type: Article

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