The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats

Journal of Cardiovascular Pharmacology

Volumn 29, Issue 6, 1997, Pages 713-725

  Chen, Shi Juan ^a   Chen, Yiu Fai ^a   Opgenorth, Terry J ^b   Wessale, Jerry L ^b   Meng, Qing Cheng ^a   Durand, Joan ^a   DiCarlo, Vick S ^a   Oparil, Suzanne ^a,c  

^a University of Alabama at Birmingham   (United States)

^b ABBOTT LABORATORIES   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Endothelin; Endothelin A receptor antagonist; Hypoxic response; Pulmonary hypertension; Vascular remodeling

Indexed keywords

1 (N,N DIBUTYLACETAMIDO) 4 (1,3 BENZODIOXOL 5 YL) 2 (4 METHOXYPHENYL)PYRROLIDINE 3 CARBOXYLIC ACID; ATRASENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART ATRIUM ENLARGEMENT; HYPOXIA; LUNG VASOCONSTRICTION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT;

ANIMALS; ANOXIA; BLOOD PRESSURE; CARDIOMEGALY; ENDOTHELIN-1; HEART RATE; HYPERTENSION, PULMONARY; MALE; PULMONARY ARTERY; PYRROLIDINES; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN;

EID: 0030814723     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199706000-00003     Document Type: Article

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