Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists

Journal of Medicinal Chemistry

Volumn 40, Issue 3, 1997, Pages 322-330

  Tasker, Andrew S ^a   Sorensen, Bryan K ^a   Jae, Hwan Soo ^a   Winn, Martin ^a   Von Geldern, Thomas W ^a   Dixon, Douglas B ^a   Chiou, William J ^a   Dayton, Brian D ^a   Calzadila, Samuel ^a   Hernandez, Lisa ^a   Marsh, Kennan C ^a   WuWong, J Ruth ^a   Opgenorth, Terry J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (N,N DIBUTYLACETAMIDO) 4 (1,3 BENZODIOXOL 5 YL) 2 (4 METHOXYPHENYL)PYRROLIDINE 3 CARBOXYLIC ACID; ATRASENTAN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING;

ACETAMIDES; ANIMALS; CELLS, CULTURED; DIOXOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROLINE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15444359698     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960077r     Document Type: Article

References (32)

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