Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3679-3689

  Liu, Gang ^a   Kozmina, Natasha S ^a,b   Winn, Martin ^a   Von Geldern, Thomas W ^a   Chiou, William J ^a   Dixon, Douglas B ^a   Nguyen, Bach ^a   Marsh, Kennan C ^a   Opgenorth, Terry J ^a  

^a ABBOTT LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 ISOPROPOXYETHOXY)PHENYL] 4 (1,3 BENZODIOXOL 5 YL) 1 (BIS 2 TOLYLMETHYLAMINOCARBONYLMETHYL)PYRROLIDINE 3 CARBOXYLIC ACID; ENDOTHELIN B RECEPTOR ANTAGONIST; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR EFFECT; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION; VASCULAR ENDOTHELIUM;

ACETAMIDES; ADMINISTRATION, ORAL; BLOOD PRESSURE; HUMANS; METHYLAMINES; PROLINE; PYRROLIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033539053     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990171i     Document Type: Article

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