Lantibiotics produced by lactic acid bacteria: Structure, function and applications

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Volumn 82, Issue 1-4, 2002, Pages 165-185

  Twomey, Denis ^a,b   Ross, R P ^b   Ryan, Maire ^a,b   Meaney, Billy ^b   Hill, C ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b ANIMAL AND GRASSLAND RESEARCH AND INNOVATION CENTRE   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BACTERIOCIN; LANTIBIOTIC; NISIN; PEPTIDE;

ANTIBIOTICS; BACTERIUM; LACTIC ACID;

ARTICLE; AUTOREGULATION; BACTERIAL IMMUNITY; BIOMEDICINE; CONTROLLED STUDY; FOOD INDUSTRY; FOOD QUALITY; FOOD SAFETY; GENETIC CODE; LACTIC ACID BACTERIUM; MOLECULAR GENETICS; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; REGULATORY MECHANISM; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; LACTOBACILLUS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0036692989     PISSN: 00036072     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020660321724     Document Type: Article

References (119)

1. Gene regulation. Action of leucine zippers
2. Genetic analysis of biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis
3. Mechanism of channel-forming lantibiotics in black lipid membranes
4. Structural analysis and proteolytic activation of Enterococcus faecalis cytolysin, a novel lantibiotic
5. The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane
6. Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic
7. Mode of action of the lantibiotic mersacidin: Inhibition of peptidoglycan biosynthesis via a novel mechanism
8. The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation
9. Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics
10. Application and evaluation of the phage resistance and bacteriocin encoding plasmid pMRC01 for the improvement of dairy starter cultures
11. Isolation and characterization of two degradation products derived from the peptide antibiotic nisin
12. Structure-activity relationships in the peptide antibiotic nisin: Role of dehydroalanine 5
13. The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc
14. Mutacin II, a bactericidal lantibiotib form Streptococcus mutans
15. Plasmid-associated haemolysin and aggregation substance production contributes to virulence in experimental enterococcal endocarditis
16. A novel means of self-protection unrelated to the bactericidal effects of the Enterococcus faecalis cytolysin
17. Ruminococcin A a new lantibiotic produced by a Ruminococcus gnavus strain isolated form human faeces
18. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin
19. Maturation pathway of nisin and other lantibiotics: Post-translationally modified antimicrobial peptides exported by gram-positive bacteria
20. Nisin and its uses as a food preservative
21. Applications of the bacteriocin, nisin
22. The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory element
23. Molecular analysis of the regulation of nisin immunity
24. Sequence and analysis of the 60 kb conjugative, bacteriocin-producing plasmid pMRC01 from Lactococcus lactis DPC3147
25. IS1675, a novel lactococcal insertion element, forms a transposon-like structure including the lacticin 481 lantibiotic operon
26. Biosynthesis of the lantibiotic nisin: Genomic organization and membrane localization of the NisB protein
27. Complete genome sequence of an M1 strain of Streptococcus pyogenes
28. NMR and circular dichroism studies on Pep5
29. Molecular characterisation of the nisin resistance region of Lactococcus lactis subsp. lactis DRC3
30. Lacticin 3147 displays activity in buffer against Gram-positive bacterial pathogens which appear insensitive in standard plate assays
31. Serine protease EpiP from Staphylococcus epidermidis catalyses the processing of the epidermin precursor peptide
32. Genetic structure of the Enterococcus faecalis plasmid pAD1-encoded cytolytic toxin system and its relationship to lantibiotic determinants
33. Trypsin mediates growth phase-dependent transcritional regulation of genes involved in biosynthesis of Ruminococcin A, a lantibiotic produced by a Ruminococcus gnavus strain from a human intestinal microbiota
34. Bactericidal mode of action of plantaricin C
35. Post-translationally modified bacteriocins - The lantibiotics
36. Two-component regulator of Enterococcus faecalis cytolysin responds to quorum sensing auto-induction
37. Sensitivity and resistance of Listeria monocytogenes ATCC 19115, Scott A and UAL500 to nisin
38. A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export
39. Plantaricin W from Lactobacillus plantarum belongs to a new family of two-component lantibiotics
40. Bacteriocin J46, a new bacteriocin produced by Lactococcus lactis subsp. cremoris J46: Isolation and characterization of the protein and its gene
41. Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49
42. High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infections
43. Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and cloning
44. The mode of action of SA-FF22, a lantibiotic from Streptococcus pyogenes strain FF22
45. Lantibiotics and Related Peptides
46. Partial purification, specificity and mechanism of action of the nisin-inactivating enzyme from Bacillus cereus
47. Contribution of the pAD1-encoded cytolysin to the severity of experimental Enterococcus faecalis endophthalmilis
48. Isolation and characterisation of a bacteriocin, Butyrivibriocin AR10, from the ruminal anaerobe Butyrivibrio fibrisolvens AR10: Evidence in support of the widespread occurrence of bacteriocin-like activity among of B. fibrisolvens
49. Structure elucidation of the tricyclic lantibiotic Pep5 containing eight positively charged amino acids
50. Purification and partial identification of bacteriocin ISK-1, a new lantibiotic produced by Pediococcus sp. ISK-1
51. Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC6633
52. Biosynthesis of the lantibiotic subtilin is regulated by a histidine kinase/response regulator system
53. Biochemical structural analysis of the lantibiotic mutacin II
54. Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis: Requirement of expression of the nisA and nisI genes for development of immunity
55. Engineering dehydrated amino acid residues in the antimicrobial peptide nisin
56. Autoregulation of nisin biosynthesis in Lactococcus lactis by signal transduction
57. Analysis of nisin A and some of its variants using Fourier transform ion cyclotron resonance mass spectrometry
58. Solution structures of nisin and its two major degradation products determined by NMR
59. Additional antibiotic inhibitors of peptidoglycan biosynthesis
60. Inhibition of Listeria monocytogenes in cottage cheese manufactured with a lacticin 3147-producing starter culture
61. Lacticin 3147, a broad-spectrum bacteriocin which selectively dissipates the membrane potential
62. Identification and overexpression of ltnI, a novel gene which confers immunity to the two-component lantibiotic, lacticin 3147
63. Regulation of immunity to the two-component lantibiotic, lacticin 3147, by the transcriptional repressor LtnR
64. Lantibiotics: Structure, biosynthesis and mode of action
65. Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation
66. Purification and amino acid sequence of lactocin S, a bacteriocin produced by Lactobacillus sake L45
67. Production and pH-dependent bacericidal activity of lactocin S, a lantibiotic from Lactobacillus sake L45
68. Two-component anti-Staphylococcus aureus lantibiotic activity produced by Staphylococcus aureus C55
69. Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus strain C55 and other phage group II S. aureus strains and demonstration of an association with the exfoliative toxin B gene
70. Effect of leader peptide mutations on biosynthesis of the lantibiotic Pep5
71. Biosynthesis of bacteriocins in lactic acid bacteria
72. Producer self-protection against the lantibiotic epidermin by the ABC transporter EpiFEG of Staphylococcus epidermidis Tu3298
73. Analysis of the Staphylococcus epidermidis genes epiF, -E, and -G involved in epidermin immunity
74. Secretion of the lantibiotics epidermin and gallidermin: Sequence analysis of the genes gdmT and gdmH, their influence on epidermin production and their regulation by EpiQ
75. Purification and partial characterisation of lacticin 481, a lanthionine-containing bacteriocin produced by Lactococcus lactis subsp. lactis CNRZ481
76. Structure, organization and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis
77. Constitution and solution conformation of the antibiotic mersacidin determined by NMR and molecular dynamics
78. Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: Comparison to lacticin 481 of Lactococcus lactis
79. Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in Streptococcus mutans
80. Evidence for a role of NisT in transport of the lantibiotic nisin produced by Lactococcus lactis N8
81. The cellular location and effect on nisin imunity of the NisI protein from Lactococcus lactis N8 expressed in Escherichia coli and L. lactis
82. Limiting factors in lactic fermentation
83. The effect of nisin on murein synthesis
84. Purification and partial amino acid sequence of plantaricin 1.25a and 1.25b, two bacteriocins produced by Lactobacillus plantarum TMW1.25
85. Cloning, expression and nucleotide sequence of genes involved in production of lactococcin DR, a bacteriocin from Lactococcus lactis subsp. lactis
86. Characterization of the lacticin 481 operon: The Lactococcus lactis genes lctF, lctE, and lctG encode a putative ABC transporter involved in bacteriocin immunity
87. PCR detection of the lactocin S structural gene in bacteriocin-producing lactobacilli from meat
88. Limiting factors in lactic fermentation
89. Isolation and characterisation of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3
90. Developing applications for lactococcal bacteriocins
91. Mode of action of the peptide antibiotic nisin and influence on the membrane potential of whole cells and on artificial membrane vesicles
92. An application in Cheddar cheese manufacture for a strain of Lactococcus lactis producing a novel broad spectrum bacteriocin, lacticin 3147
93. Evaluation of lacticin 3147 and a teat seal containing bacteriocin for the inhibition of mastitis pathogens
94. Extensive -translational modification, including a serine to D-alanine conversion, in the two-component lantibiotic, lacticin 3147
95. Voltage-dependent depolarization of bacterial membranes and artificial lipid bilayers by the peptide antibiotic nisin
96. Lantibiotics: Biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria
97. Molecular characterization of the Enterococcus faecalis cytolysin activator
98. Genes involved in immunity to the lantibiotic nisin produced by Lactococcus lactis 6F3
99. Comparison of lantibiotic gene clusters and encoded proteins
100. In vivo conversion of L-serine to D-alanine in a ribosomally synthesized polypeptide
101. Organisation and expression of a gene cluster involved in the biosynthesis of the lantibiotic, lactocin S
102. Identification, characterisation and expression of a second bicistronic operon involved in the production of lactocin S in Lactocbacillus sake L45
103. Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis
104. Solution structure of plantaricin C, a novel lantibiotic
105. Protection against Staphylococcus aureus mastitis in dairy cows using a bismuth-based teat seal containing the bacteriocin, lacticin 3147
106. Influence of osmolarity and the presence of an osmoprotectant on Lactococcus lactis growth and bacteriocin production
107. NMR-studies of lantibiotics: The structure of nisin in aqueous solution
108. Three-dimensional structure of the lantibiotic nisin in the presence of membrane mimetic micelles of dodecylphosphocholine and of sodium dodecysulphate
109. The structure of the lantibiotic lacticin 481 produced by Lactococcus lactis: Location of the thioether bridges
110. Structural features of the final intermediate in the biosynthesis of the lantibiotic nisin. Influence of the leader peptide
111. Characterization of the Lactococcus lactis nisin A operon: Genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis
112. Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis
113. Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP requiring enzymes and a common nucleotide binding fold
114. A substance inhibiting bacterial growth, produced by certain strains of lactic streptococci
115. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and the inhibition of cell wall biosynthesis for potent antibiotic activity
116. Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans
117. Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C
118. The three dimensional solution structure of the lantibiotic murein-biosynthesis-inhibitor actagardine determined by NMR