Evidence for a role of NisT in transport of the lantibiotic nisin produced by Lactococcus lactis N8

FEMS Microbiology Letters

Volumn 144, Issue 1, 1996, Pages 89-93

  Qiao, Mingqiang ^a   Saris, Per E J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

ABC transporter; Lactococcus lactis; lantibiotics; nisin transport; NisT

Indexed keywords

LANTIBIOTIC; NISIN;

ACTIVE TRANSPORT; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; LACTOCOCCUS LACTIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

LACTOCOCCUS LACTIS; STREPTOCOCCUS;

EID: 0030588060     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1097(96)00344-8     Document Type: Article

References (20)

1. [1] Sahl, H.-G., Jack, R.W. and Bierbaum, G. (1995) Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur. J. Biochem. 230, 827-853.
2. [2] Van der Meer, J.R., Polman, J., Beerthuyzen, M.M., Siezen, R.J., Kuipers, O.P. and de Vos, W. (1993) Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis. J. Bacteriol. 174, 2152-2159.
3. [3] Qiao, M., Ye, S., Koponen, O., Ra, R., Immonen, T. and Saris, P.E.J. (1996) Regulation of the nisin operons in Lactococcus lactis N8. J. Appl. Bact. 80, 626-634.
4. [4] Meyer, C., Bierbaum, G., Heidrich, C., Reis, M., Suling, J., Iglesias-wind, M.I., Kempter, C., Molitor, E. and Sahl, H.-G. (1995) Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC: Evidence for a role of PepC in thioher formation. Eur. J. Biochem. 232, 478-489.
5. [5] Van de Kamp, M., van den Hooven, H.W., Konings, R.N.H., Hilbers, C.W., van de Ven, F.J.M., Bierbaum, G., Sahl, H.-G., Kuipers, O.P., Siezen, R.J. and de Vos, W.M. (1995) Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7-cloning of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7. Eur. J. Biochem. 230, 587-600.
6. [6] Kuipers, O.P., Beerthuyzen, M.M., Siezen, R.J. and de Vos, W. (1993) Characterization of the nisin gene cluster nisABT-CIPR of Lactococcus lactis: Requirement of expression of the nisA and nisI genes for development of nisin immunity. Eur. J. Biochem. 216, 281-291.
7. [7] Engelke, G., Gutowski-Eckel, Z., Kiesau, P., Siegers, K., Hammelmann, M. and Entian, K.-D. (1994) Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3. Appl. Environ. Microbiol. 60, 814-825.
8. [8] Immonen, T., Ye, S., Ra, R., Qiao, M., Paulin, L. and Saris, P.E.J. (1995) The codon usage of the nisZ operon in Lactococcus lactis N8 suggests a non-lactococcal origin of the conjugative nisin-sucrose transposon. DNA Sequence 5, 203-218.
9. [9] Chung, Y.J., Steen, M.T. and Hansen, J.N. (1992) The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein. J. Bacteriol. 174, 1417-1422.
10. [10] Klein, C. and Entian, K.-D. (1994) Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633. Appl. Environ. Microbiol. 60, 2793-2801.
11. [11] Schell, N., Engelke, G., Augustin, J., Rosenstein, R., Ungerman, V., Götz, F. and Entian, K.-D. (1992) Analysis of genes involved in biosynthesis of the lantibiotic epidermin. Eur. J. Biochem. 204, 57-68.
12. [12] Peschel, A. and Götz, F. (1996) Analysis of the Staphylococcus epidermidis Genes epiF, -E, and -G involved in epidermin immunity. J. Bacteriol. 178, 531-536.
13. [13] Augustin, J., Rosenstein, R., Wieland, B., Schneider, U., Schnell, N., Engelke, G., Entian, K.-D. and Götz, F. (1992) Genetic analysis of epidermin biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis. Eur. J. Biochem. 204, 1149-1154.
14. [14] Graeffe, T., Rintala, H., Paulin, L. and Saris, P. (1991) A natural nisin variant. In Nisin and Novel Lantibiotics (Jung, G. and Sahl, H.-G., Eds.) pp. 260-268, ESCOM, Leiden.
15. [15] Ra, S.R., Qiao, M., Immonen, T., Koponen, O., Pujana, I. and Saris, P.E.J. (1996) Genes responsible for nisin synthesis, regulation and immunity form a regulon of two operons and are induced by nisin in Lactococcus lactis N8. Microbiology 142, 1281-1288.
16. [16] Gasson, M.J. (1983) Plasmid complements of Streptococcus lactis NCDO712 and other lactic streptococci after protoplast induced curing. J. Bacteriol. 154, 1-9.
17. [17] Maniatis, T., Fritsch, E.F. and Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. [18] Sibakov, M., Koivula, T., von Wright, A. and Palva, I. (1991) Secretion of TEM β-lactamase with signal sequences isolated from the chromosome of Lactococcus lactis subsp. lactis. Environ. Microbiol. 75, 341-348.
19. [19] Schägger, H. and von Jagow, G. (1987) Tricine-sodium dodecyl sulphate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Ann. Biochem. 166, 368-379.
20. [20] Van der Meer, J.R., Rollema, H.S., Siezen, R.J., Beerthuyzen, M.M., Kuipers, O.P. and de Vos, W.M. (1994) Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis. J. Biol. Chem. 269, 3555-3562.