Secretion of the lantibiotics epidermin and gallidermin: Sequence analysis of the genes gdmT and gdmH, their influence on epidermin production and their regulation by EpiQ

Molecular and General Genetics

Volumn 254, Issue 3, 1997, Pages 312-318

  Peschel, A ^a   Schnell, N ^b   Hille, M ^a   Entian, K D ^c   Gotz F ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b ASTRAZENECA   (United Kingdom)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

ABC transporter; Epidermin; Gallidermin; Lantibiotic secretion; Sequence analysis

Indexed keywords

ABC TRANSPORTER; EPIDERMIN; GALLIDERMIN; GENE PRODUCT; LANTIBIOTIC;

ARTICLE; BIOSYNTHESIS; DRUG MANUFACTURE; FRAMESHIFT MUTATION; GENE CONTROL; GENE DELETION; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; STAPHYLOCOCCUS EPIDERMIDIS; TRANSCRIPTION REGULATION;

EID: 0030983728     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050421     Document Type: Article

References (36)

1. Allgaier H, Jung G, Werner RG, Schneider U, Zähner H (1985) Elucidation of the structure of epidermin, a ribosomally synthesized, tetracyclic heterodetic polypeptide antibiotic. Angew Chem Int Ed Engl 24:1051-1053
2. Augustin J, Götz F (1990) Transformation of Staphylococcus epidermidis and other staphylococcal species with plasmid DNA by electroporation. FEMS Microbiol Lett 66:203-208
3. Augustin J, Rosenstein R, Wieland B. Schneider U, Schnell N, Engelke G. Entian K-D, Götz F (1992) Genetic analysis of epidermin biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis. Eur J Biochem 204:1149-1154
4. Axelsson L, Holck A (1995) The genes involved in production of and immunity to sakacin A, a bacteriocin from Lactobacillus sake Lb706. J Bacteriol 177:2125-2137
5. Bierbaum G, Götz F, Peschel A, Kupke T, van de Kamp M, Sahl H-G (1996) The biosynthesis of the lantibiotics epidermin. gallidermin, Pep5 and epilancin K7. Antonie van Leeuwenhoek 69:119-127
6. Brückner R (1992) A series of shuttle vectors for Bacillus subtilis and Escherichia coli. Gene 122:187-192
7. De Vos WM, Kuipers OP, van der Meer JR, Siezen RJ (1995) Maturation pathway of nisin and other lantibiotics: posttranslationally modified antimicrobial peptides exported by Gram-positive bacteria. Mol Microbiol 17:427-437
8. Diep DB, Havarstein LS, Nes IF (1996) Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11. J Bacteriol 178:4472-4483
9. Fath MJ, Kolter R (1993) ABC transporters: bacterial exporters. Microbiol Rev 57:995-1017
10. Franke CM, Leenhouts KJ, Haandrikman AJ, Kok J, Venema G, Venema K (1996) Topology of LcnD, a protein implicated in the transport of bacteriocins from Lactococcus lactis. J Bacteriol 178:1766-1769
11. Geißler S, Götz F, Kupke T (1996) Serine protease EpiP from Staphylococcus epidermidis catalyzes the processing of the epidermin precursor peptide. J Bacteriol 178:284-288
12. Gentsehev I, Goebel W (1992) Topological and functional studies on HlyB of Escherichia coli. Mol Gen Genet 232:40-48
13. Götz F, Schumacher B (1987) Improvements of protoplast transformation in Staphylococcus carnosus. FEMS Microbiol Lett 40:285-288
14. Higgins CF (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67-113
15. Kellner R, Jung G, Hörner T, Zähner H, Schnell N, Entian K-D, Götz F (1988) Gallidermin: a new lanthionine-containing polypeptide antibiotic. Eur J Biochem 177:53-59
16. Klein C, Kaletta C, Schnell N, Entian K-D (1992) Analysis of genes involved in biosynthesis of the lantibiotic subtilin. Appl Environ Microbiol 58:132-142
17. Kuipers OP, Beerthuyzen MM, Siezen RJ, de Vos WM (1993) Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Eur J Biochem 216:281-291
18. Kupke T, Götz F (1996a) Expression, purification, and characterization of EpiC, an enzyme involved in the biosynthesis of the lantibiotic epidermin, and sequence analysis of Staphylococcus epidermidis epiC mutants. J Bacteriol 178:1335-1340
19. Kupke T, Götz F (1996b) Post-translational modifications of lantibiotics. Antonie van Leeuwenhoek 69:139-150
20. Kupke T, Kempter C, Gnau V, Jung G, Götz F (1994) Mass spectroscopic analysis of a novel enzymatic reaction. J Biol Chem 269:5653-5659
21. Meyer C, Bierbaum G, Heidrich C, Reis M, Süling J, Iglesias-Wind MI, Kempter C, Molitor E, Sahl H-G (1995) Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Eur J Biochem 232:478-489
22. Ottenwälder B, Kupke T, Brecht S, Gnau V, Metzger J, Jung G, Götz F (1995) Isolation and characterization of genetically engineered gallidermin and epidermin analogs. Appl Environ Microbiol 61:3894-3903
23. Peschel A, Augustin J, Kupke T, Stevanovic S, Götz F (1993) Regulation of epidermin biosynthetic genes by EpiQ. Mol Microbiol 9:31-39
24. Peschel A, Götz F (1996) Analysis of the Staphylococcus epidermidis genes epiF, E, and G involved in epidermin immunity. J Bacteriol 178:531-536
25. Peschel A, Ottenwälder B, Götz F (1996) Inducible production and cellular location of the epidermin biosynthetic enzyme EpiB using an improved staphylococcal expression system. FEMS Microbiol Lett 137:279-284
26. Sahl H-G, Jack RW, Bierbaum G (1995) Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem 230:827-853
27. Sahl H-G (1991) Pore formation in bacterial membranes by cationic lantibiotics. In: Jung G, Sahl H-G (eds) Nisin and novel lantibiotics. Escom, Leiden, pp 347-358
28. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
29. Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Götz F, Entian K-D (1992) Analysis of genes involved in the biosynthesis of lantibiotic epidermin. Eur J Biochem 204:57-68
30. Schnell N, Entian K-D, Götz F, Hörner T, Kellner R, Jung G (1989) Structural gene isolation and prepeptide sequence of gallidermin, a new lanthionine containing antibiotic. FEMS Microbiol Lett 58:263-268
31. Schnell N, Entian K-D, Schneider U, Götz F, Zähner H, Kellner R. Jung G (1988) Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide rings. Nature 333:276-278
32. Schülein R, Gentschev I, Senior S, Groß R, Goebel W (1994) Identification and characterization of two functional domains of the hemolysin translocator protein HlyD. Mol Gen Genet 245:203-211
33. Siezen RJ, Kuipers OP, de Vos WM (1996) Comparison of lantibiotic gene clusters and encoded proteins. Antonie van Leeuwenhoek 69:171-184
34. Skvirsky RC, Reginald S, Shen X (1995) Topology analysis of the colicin V export protein CvaA in Escherichia coli. J Bacteriol 177:6153-6159
35. Vieira J, Messing J (1982) The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19:259-268
36. Yanisch-Perron C, Vieira J, Messing J (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119