Organization and expression of a gene cluster involved in the biosynthesis of the lantibiotic lactocin S

Molecular and General Genetics

Volumn 253, Issue 6, 1997, Pages 674-686

  Skaugen, M ^a   Abildgaard, C I M ^a   Nes, I F ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

Bacteriocin; D amino acid; Insertion sequence; Lantibiotic; Post translational modification

Indexed keywords

ADENOSINE TRIPHOSPHATE; LACTOCIN S; LANTIBIOTIC;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BIOSYNTHESIS; GENE CLUSTER; GENE SEQUENCE; LACTOBACILLUS; NONHUMAN; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; PROTEIN SECRETION; TRANSPOSON;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, BACTERIAL; GENE EXPRESSION; LACTOBACILLUS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; OPERON; PEPTIDES; TRANSCRIPTION, GENETIC;

EID: 0030964778     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050371     Document Type: Article

References (59)

1. Abildgaard CIM (1992) Lactocin S, a lanthionine-containing bacteriocin from Lactobacillus sake. Ph.D. thesis, Agricultural University of Norway, Ås, Norway
2. Abilgaard CIM, Nissen-Meyer J, Jelle B, Grenov B, Skaugen M, Nes IF (1995) Production and pH-dependent bactericidal activity of lactocin S, a lantibiotic from Lactobacillus sake L45. Appl Environ Microbiol 61:175-179
3. Alam J, Whitaker RA, Krogmann DW, Curtis SE (1986) Isolation and sequence of the gene for ferredoxin I from the cyanobacterium Anabaena sp. strain PCC7120. J Bacteriol 168:1265-1271
4. Augustin J, Rosenstein R, Wieland B, Schneider U, Schnell N, Engelke G, Entian K-D, Götz F (1992) Genetic analysis of epidermin biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis. Eur J Biochem 204:1149-1154
5. Banerjee S, Hansen JN (1988). Structure and expression of a gene encoding the precursor of subtilin, a small protein antibiotic. J Biol Chem 263:9508-9514
6. Belasco JG, Higgins CF (1988) Mechanisms of mRNA decay in bacteria: a perspective. Gene 72:15-23
7. Bierbaum G, Sahl H-G (1993) Lantibiotics - unusually modified bacteriocin-like peptides from Gram-positive bacteria. Zbl Bakt 278:1-22
8. Buchman GW, Banerjee S, Hansen JN (1988) Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic. J Biol Chem 263:16260-16266
9. Carter P, Wells JA (1988) Dissecting the catalytic triad of serine proteases. Nature 332:564-568
10. Chung YJ, Steen MT, Hansen JN (1992) The subtilin gene of Bacillus suhtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein. J Bacteriol 174:1417-1422
11. Church GM, Gilbert W (1984) Genomic sequencing. Proc Natl Acad Sci USA 81:1991-1995
12. Engelke G, Gutowski-Eckel Z, Hammelmann M, Entian K-D (1992) Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein. Appl Environ Microbiol 58:3730-3743
13. Fath MJ, Kolter R (1993) ABC transporters: bacterial exporters. Microbiol Rev 57:995-1017
14. Galas DJ, Chandler M (1989) Bacterial insertion sequences. In: Berg DE, Howe MM (eds) Mobile DNA. American Society for Microbiology, Washington DC, pp 109-162
15. Genetics Computer Group (1991) Program manual for the GCG package, version 7. Madison, Wisconsin
16. Gilmore MS, Segarra RA, Booth MC (1990) An HlyB-type function is required for expression of the Enterococcus faecalis hemolysin/bacteriocin. Infect Immun 58:3914-3923
17. Gilmore MS, Segarra RA, Booth MC, Bogie CP, Hall LR, Clewell DB (1994) Genetic structure of the Enterococcux faecalis plasmid pAD1-encoded cytolytic toxin system and its relationship to lantibiotic determinants. J Bacteriol 176:7335-7344
18. Haandrikman AJ, van Leeuwen C, Kok J, Vos P, de Vos WM, Venema G (1990) Insertion elements on lactococcal proteinase plasmids. Appl Environ Microbiol 56:1890-1896
19. Higgins CF, Causton HC, Dance GSC, Mudd EA (1993) The role of the 3′ end in mRNA stability and decay. In: Belasco J, Brawerman G (eds) Control of messenger RNA stability. Academic Press, San Diego, pp 13-30
20. Hultman T, Ståhl S, Hornes E, Uhlén M (1989) Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support. Nucleic Acids Res 17:4937-4946
21. Håvarstein LS, Holo H, Nes IF (1994) The leader peptide of colicin V shares consensus sequences with leader peptides that are common among peptide bacteriocins produced by Gram-positive bacteria. Microbiology 140:2383-2389
22. Håvarstein LS, Diep DB, Nes IF (1995) A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol 16:229-240
23. Igo MM, Losick R (1986) Regulation of a promoter that is utilized by minor forms of RNA polymerase holoenzyme in Bacillus subtilis. J Mol Biol 191:615-624
24. Jung G (1991) Lantibiotics: a survey. In: Jung G, Sahl H-G (eds) Nisin and novel lantibiotics. ESCOM, Leiden, pp 1-34
25. Klaenhammer TR (1993) Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev 12:39-86
26. Klein C (1993) Biosynthese des Peptidantibiotikums Subtilin. PhD thesis, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Federal Republic of Germany
27. Klein C, Entian, K-D (1994) Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633. Appl Environ Microbiol 60:2793-2801
28. Klein C, Kaletta C, Schnell N, Entian K-D (1992) Analysis of genes involved in biosynthesis of the lantibiotic subtilin. Appl Environ Microbiol 58:132-142
29. Koide Y, Nakamura A, Uozumi T, Beppu T (1986) Cloning and sequencing of the major intracellular serine protease gene of Bacillus subtilis. J Bacteriol 167:110-116
30. Kraft R, Tardiff J, Krauter KS, Leinwand LA (1988) Using miniprep plasmid DNA for sequencing double-stranded templates with Sequenase. Biotechniques 6:544-547
31. Kreil G (1994) Peptides containing a D-amino acid from frogs and molluscs. J Biol Chem 269:10967-10970
32. Kuipers OP, Beerthuyzen MM, Siezen RJ, de Vos WM (1993) Characterization of the nisin-gene cluster nisABTCIPR of Lactococcus lactis. Expression requirement of the nisA and nisI genes for producing immunity. Eur J Biochem 216:281-291
33. Kupke T, Götz F (1996) Expression, purification, and characterization of EpiC, an enzyme involved in the biosynthesis of the lantibiotic epidermin, and sequence analysis of Staphylococcus epidermidis epiC mutants. J Bacteriol 178:1335-1340
34. Kupke T, Stevanovic S, Sahl H-G, Götz F (1992) Purification and characterization of EpiD, a flavoprotein involved in the biosynthesis of the lantibiotic epidermin. J Bacteriol 174:5354-5361
35. Kupke T, Kempter C, Jung G. Götz F (1995) Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD. J Biol Chem 270:11282-11289
36. Kupke T, Kempter C, Gnau V, Jung G, Götz F (1994) Mass spectrometric analysis of a novel enzymatic reaction:oxidative decarboxylation of the lantibiotic precursor peptide EpiA catalyzed by the flavoprotein EpiD. J Biol Chem 269:5653-5659
37. Marmur J (1961) A procedure for the isolation of deoxyribonucleic acid from microorganisms. J Mol Biol 3:208-218
38. Meyer C, Bierbaum G, Heidrich C, Reis M, Süling J, Iglesias-Wind MI, Kempter C, Molitor E, Sahl H-G (1995) Nucleotide sequence of the lantibiotic Pep5 bilsynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation. Eur J Biochem 232:478-489
39. Mor A, Amiche M, Nicholas P (1992) Enter a new post-translational modification: D-amino acids in gene-encoded peptides. Trends Biochem Sci 17:481-485
40. Mørtvedt CI, Nes IF (1990) Plasmid-associated bacteriocin production by a Lactobacillus sake strain. J Gen Microbiol 136:1601-1607
41. Mørtvedt CI, Nissen-Meyer J, Sletten K, Nes IF (1991) Purification and amino acid sequence of lactocin S, a bacteriocin produced by Lactobacillus sake L45. Appl Environ Microbiol 57:1829-1834
42. Peschel A, Götz F (1996) Analysis of the Staphylococcus epidermidis genes epiF, E, and G involved in epidermin immunity. J Bacteriol 178:531-536
43. Piard J-C., Kuipers O, Rollema HS, Desmazeaud MJ, de Vos WM (1993) Structure, organization, and expression of the let gene for lacticin 481, a novel lantibiotic produced by L. actis supsp. lactis CNRZ 481. J Biol Chem 268:16361-16368
44. Pouwels PH, Leer RJ (1993) Genetics of Lactobacilli. Plasmids and gene expression. Antonie van Leeuwenhoek 64:83-105
45. Qiao M, Immonen T, Koponen O, Saris PEJ (1995) The cellular location and effect on nisin immunity of the Nisi protein from Lactococcus lactis N8 in Escherichia coli and L. actis. FEMS Microbiol Lett 131:75-80.
46. Reis M, Sahl, H-G (1991) Genetic analysis of the producer self-protection mechanism ("immunity") against Pep5. In: Jung G. Sahl H-G (eds) Nisin and novel lantibiotics. ESCOM, Leiden, pp 320-331
47. Rince A, Dufour A, LePogam S, Thuault D, Bourgeois CM, Le-Pennec JP (1994) Cloning, expression, and nucleotide sequence of genes involved in production of lactococcin DR, a bacteriocin from Lactococcus lactis supsp. lactis. Appl Environ Microbiol 60:1652-1657
48. Suhl H-G, Jack RW, Bierbaum G (1995) Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem 230:827-853
49. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual (2nd edn.) Cold Spring Harbor Laboratory, Press Cold Spring Harbor, New york
50. Schnell N, Entian K-D, Schneider U, Götz F, Zähner H, Kellner R, Jung G (1988) Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphiderings. Nature 333:276-278
51. Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Götz F, Entian K-D (1992) Analysis of genes involved in the biosynthesis of the lantibiotic epidermin. Eur J Biochem 204:57-68
52. Segarra RA (1992) Molecular characterization of the Enterococcus faecalis hemolysin/bacteriocin determinant. Ph.D. thesis, University of Oklahoma, Oklahoma City
53. Siegers K, Entian K-D (1995) Genes involved in immunity to the lantibiotic nisin produced by Lactococcus lactis 6F3. Appl Environ Microbiol 61:1082-1089
54. Siezen RJ, de Vos WM, Leunissen JAM, Dijkstra BW (1991) Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases. Protein Eng 4:719-737
55. Skaugen M, Nes IF (1994) Transposition in Lactobacillus sake and its abolition of lactocin S production by insertion of IS1163, a new member of the IS3 family. Appl Environ Microbiol 60:2818-2825
56. Skaugen M, Nissen-Meyer J, Jung G, Stevanovic S, Sletten K, Abildgaard CIM, Nes IF (1994) In vivo conversion of L-serine to D-alanine in a ribosomally synthesized polypeptide. J Biol Chem 269:27183-27185
57. Van der Meer JR, Polman J, Beerthuyzen M, Siezen RJ, Kuipers OP, de Vos WM (1993), Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisinlike serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis. J Bacteriol 175:2578-2588
58. Von Heijne G (1992) Membrane structure prediction. Hydrophobicity analysis and the positive-inside rule. J Mol Biol 225:487-494
59. Yang W, Ni L, Somerville RL (1993) A stationary-phase protein of Escherichia coli that affects the mode of association between the trp repressor and operator-bearing DNA. Proc Natl Acad Sci USA 90:5796-5800