Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant

Nucleic Acids Research

Volumn 30, Issue 15, 2002, Pages 3395-3400

  Bundock, Paul ^a   van Attikum, Haico ^a   Hooykaas, Paul ^a  

^a Inst of Molecular Plant Sciences   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID METHYL ESTER; PLANT DNA;

ARABIDOPSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FERTILITY; GENE FUNCTION; GENE IDENTIFICATION; GENE INSERTION; HOMOZYGOTE; HYPERSENSITIVITY; HYPOTHESIS; IONIZING RADIATION; MAMMAL CELL; MUTANT; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TELOMERE; WILD TYPE; YEAST CELL;

AMINO ACID SEQUENCE; ANTIGENS, NUCLEAR; ARABIDOPSIS; ARABIDOPSIS PROTEINS; DNA DAMAGE; DNA HELICASES; DNA, PLANT; DNA-BINDING PROTEINS; GENES, PLANT; METHYL METHANESULFONATE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; RADIATION TOLERANCE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; TELOMERE;

ARABIDOPSIS; ARABIDOPSIS THALIANA; INSERTION SEQUENCES; MAMMALIA;

EID: 0036682102     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf445     Document Type: Article

References (35)

1. Recombination: A frank view of exchanges and vice versa
2. Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast
3. Identification of bacterial homologues of the Ku DNA repair protein
4. Ku, a DNA repair protein with multiple cellular functions?
5. Ku recruits the XRCC4-ligase IV complex to DNA ends
6. Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
7. Ku70-deficient embryonic stem cells have increased ionizing radiation sensitivity, defective DNA end-binding activity and inability to support V(D)J recombination
8. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
9. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
10. Growth retardation and leaky SCID phenotype of Ku70 deficient mice
11. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival and development
12. Telomeres and double strand breaks: Trying to make ends meet
13. T-DNA as an insertional mutagen in Arabidopsis
14. RAD50 function is essential for telomere maintenance in Arabidopsis
15. Involvement of Arabidopsis thaliana ribosomal protein S27 in mRNA degradation triggered by genotoxic stress
16. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity and inability to support V(D)J recombination
17. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
18. Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity
19. Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA
20. Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis
21. The repressor which binds the -75 GATA motif of the GPB promoter contains Ku70 as the DNA binding subunit
22. Developmental control of telomere lengths and telomerase activity in plants
23. Effects of DNA nonhomologous end joining factors on telomere length and chromosomal stability in mammalian cells
24. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
25. csis critical for telomere capping
26. The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
27. Control of telomere length by the human telomeric protein TRF1
28. Ku acts in a unique way at the mammalian telomere to prevent end joining
29. Interaction of human Ku70 with TRF2
30. Control of human telomere length by TRF1 and TRF2
31. A plant gene encoding a Myb-like protein that binds telomeric GGTTTAG repeats in vitro
32. -senescence
33. Recombination in telomere length maintenance
34. Living with genome instability: Plant responses to telomere dysfunction
35. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku