Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57BI/6 mice

Virology

Volumn 255, Issue 1, 1999, Pages 106-116

  Pewe, Lecia ^a   Perlman, Stanley ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; T LYMPHOCYTE RECEPTOR; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; IMMUNE RESPONSE; IN VIVO STUDY; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SUPPRESSOR CELL; VIRUS INFECTION; VIRUS MUTATION;

EID: 0033102439     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9576     Document Type: Article

References (56)

1. Altman J., Moss P., Goulder P., Barouch D., McHeyzer-Williams M., Bell J., McMichael A., Davis M. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:1996;94-96.
2. b. J. Gen. Virol. 77:1996;315-325.
3. Bertoletti A., Costanzo A., Chisari F. V., Levero M., Artini M., Sette A., Penna A., Giuberti T., Fiaccadori F., Ferrari C. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J. Exp. Med. 180:1994a;933-943.
4. Bertoletti A., Sette A., Chisari F. V., Penna A., Levrero M., De Carli M., Fiaccadori F., Ferrari C. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature. 369:1994b;407-410.
5. Callan M. F. C., Steven N., Krausa P., Wilson J. D. K., Moss P. A. H., Gillespie G. M., Bell J. I., Rickinson A. B., McMichael A. J. Large clonal expansions of CD8 T cells in acute infectious mononucleosis. Nat. Med. 2:1996;906-911.
6. Carson R., Vignali K., Woodland D., Vignali D. T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage. Immunity. 7:1997;387-399.
7. Casanova J.-L., Maryanski J. Antigen-selected T-cell receptor diversity and self-nonself homology. Immunol. Today. 14:1993;391-394.
8. Castro R. F., Evans G. D., Jaszewski A., Perlman S. Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells. Virology. 200:1994;733-743.
9. +. J. Virol. 69:1995;8127-8131.
10. Castro R. F., Perlman S. Differential antigen recognition by T cells from the spleen and central nervous system of coronavirus-infected mice. Virology. 222:1996;247-251.
11. Chen Z., Kou Z., Lekutis C., Shen L., Zhou D., Halloran M., Li J., Sodroski J., Lee-Parvitz D., Letvin N. T cell receptor Vβ repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus. J. Exp. Med. 182:1995;21-31.
12. Cole G., Hogg T., Woodland D. T cell recognition of the immunodominant Sendai virus NP324-332/Kb epitope is focused on the center of the peptide. J. Immunol. 155:1995;2841-2848.
13. Cole G. A., Hogg T. L., Woodland D. L. The MHC class I-restricted T cell response to Sendai virus infection in C57BL/6 mice: A single immunodominant epitope elicits an extremely diverse repertoire of T cells. Int. Immunol. 6:1994;1767-1775.
14. +. Eur. J. Immunol. 27:1997;2310-2316.
15. Cose S. C., Kelly J. M., Carbone F. R. Characterization of a diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V β bias. J. Virol. 69:1995;5849-5852.
16. Cserr H. F., Knopf P. M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view. Immunol. Today. 13:1992;507-512.
17. De Campos-Lima P.-O., Levitsky V., Imreh M. P., Gavioli R., Masucci M. G. Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 186:1997;83-89.
18. De Campos-Lima P. O., Levitsky V., Brooks J., Lee S. P., Hu L., Rickinson A. B., Masucci M. G. T cell responses and virus evolution: Loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues. J. Exp. Med. 179:1994;1297-1305.
19. Deckhut A. M., Allan W., McMickle A., Eichelberger M., Blackman M. A., Doherty P. C., Woodland D. L. Prominent usage of Vβ8.3 T cells in the H-2Db-restricted response to an influenza A virus nucleoprotein epitope. J. Immunol. 151:1993;2658-2666.
20. Ehl S., Hombach J., Aichele P., Hengartner H., Zinkernagel R. M. Bystander activation of cytotoxic T cells: Studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J. Exp. Med. 185:1997;1241-1251.
21. Falk K., Rotzschke O. Consensus motifs and peptide ligands of MHC class I molecules. Semin. Immunol. 5:1993;81-94.
22. Fisher R. A., Corbet A. S., Williams C. B. The relationship between the number of species and the number of individuals in a random sample of an animal population. J. Anim. Ecol. 12:1943;42-58.
23. +. Immunity. 8:1998;683-691.
24. Franco A., Ferrari C., Sette A., Chisari F. V. Viral mutations, TCR antagonism and escape from the immune response. Curr. Opin. Immunol. 7:1995;524-531.
25. Garcia K. C., Degano M., Stanfield R., Brunmark A., Jackson M. R., Peterson P. A., Teyton L., Wilson I. A. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science. 274:1996;209-219.
26. b. J. Biol. Chem. 271:1996;17829-17836.
27. b. Mol. Immunol. 32:1995;895-907.
28. Imrich H., Schwender S., Hein A., Dorries R. Cervical lymphoid tissue but not the central nervous system supports proliferation of virus-specific T lymphocytes during coronavirus-induced encephalitis in rats. J. Neuroimmunol. 53:1994;73-81.
29. Irani D. N., Lin K.-I., Griffin D. E. Regulation of brain-derived T cells during acute central nervous system inflammation. J. Immunol. 158:1997;2318-2326.
30. Janeway C. A. A tale of two T cells. Immunity. 8:1998;391-394.
31. Kalams S., Johnson R., Trocha A., Dynan M., Ngo H., D'Aquila R., Kurnick J., Walker B. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1994;1261-1271.
32. Klenerman P., Rowland-Jones S., McAdam S., Edwards J., Daenke S., Lalloo D., Koppe B., Rosenberg W., Boyd D., Edwards A., Glangrande P., Phillips R. E., McMichael A. J. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 gag variants. Nature. 369:1994;403-407.
33. Krebs C. J. Ecological Methodology. 1989;Harper & Row, New York.
34. Lynch F., Doherty P. C., Ceredig R. Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection. J. Immunol. 142:1989;3592-3598.
35. Maryanski J., Jongeneel C., Bucher P., Casanova J.-L., Walker P. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: A high magnitude CD8 response is comprised of very few clones. Immunity. 4:1996;47-55.
36. May R. M. Patterns of species abundance and diversity. Ecology and Evolution of Communities. 1975;Harvard Univ. Press, Cambridge. p. 81-120.
37. McMichael A. J., Phillips R. E. Escape of human immunodeficiency virus from immune control. Annu. Rev. Immunol. 15:1997;271-296.
38. Murali-Krishna K., Altman J. D., Suresh M., Sourdive D., Zajac A., Miller J., Slansky J., Ahmed R. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection. Immunity. 8:1998;177-187.
39. Naumov Y. N., Hogan K. T., Naumova E. N., Pagel J. T., Gorski J. A class I MHC-restricted recall response to a viral peptide is highly polyclonal despite stringent CDR3 selection: Implications for establishing memory T cell repertoires in "real world" conditions. J. Immunol. 160:1998;2842-2852.
40. +. Nature. 370:1994;463-467.
41. Perlman S., Schelper R., Bolger E., Ries D. Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody. Microb. Pathog. 2:1987;185-194.
42. Pewe L., Wu G., Barnett E. M., Castro R., Perlman S. Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease. Immunity. 5:1996;253-262.
43. Pewe L., Xue S., Perlman S. Cytotoxic T cell-resistant variants arise at early times after infection in C57Bl/6 but not in SCID mice infected with a neurotropic coronavirus. J. Virol. 71:1997;7640-7647.
44. Pewe L., Xue S., Perlman S. Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus. J. Virol. 72:1998;5912-5918.
45. Phillips R. E., Rowland-Jones S., Nixon D. F., Gotch F. M., Edwards J. P., Ogunlesi A. O., Elvin J. G., Rothbard J. A., Bangham C. R. M., Rizza C. R., McMichael A. J. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature. 354:1991;453-459.
46. Pircher H., Moskophidis D., Rohrer U., Burki K., Hengartner H., Zinkernagel R. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature. 346:1990;629-633.
47. Price D., Goulder P., Klenerman P., Sewell A., Easterbrook P., Troop M., Bangham C. R., Phillips R. E. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA. 94:1997;1890-1895.
48. Sourdive D., Murali-Krishna K., Altman J. D., Zajac A. J., Whitmire J., Pannetier C., Kourilsky P., Evavold B., Sette A., Ahmed A. Conserved T cell receptor repertoire in primary and memory CD8 T cell response to an acute viral infection. J. Exp. Med. 188:1998;71-82.
49. Stevenson P., Freeman S., Bangham C. R. M., Hawke S. Virus dissemination through the brain parenchyma without immunologic control. J. Immunol. 159:1997a;1876-1884.
50. Stevenson P. G., Hawke S., Sloan D. J., Bangham C. R. M. The immunogenicity of intracerebral virus infection depends on anatomical site. J. Virol. 71:1997b;145-151.
51. Stohlman S. A., Kyuwa S., Polo J. M., Brady D., Lai M. M. C., Bergmann C. C. Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain. J. Virol. 67:1993;7050-7059.
52. Weiner A., Erickson A., Kanospon J., Crawford K., Muchmore E., Hughes A., Houghton M., Walker C. M. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc. Natl. Acad. Sci. USA. 92:1995;2755-2759.
53. Wolinsky S. M., Korber B., Neumann A. U., Daniels M., Kunstman K., Whetsell A., Furtado M., Cao Y., Ho D., Safrit J., Koup R. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science. 272:1996;537-542.
54. Xue S., Perlman S. Antigen specificity of CD4 T cell response in the central nervous system of mice infected with mouse hepatitis virus. Virology. 238:1997;68-78.
55. Young A., Zhang W., Sacchettini J., Nathenson S. The three-dimensional structure of H-2D at 2.4 Å resolution: Implications for antigen-determinant selection. Cell. 76:1994;39-50.
56. Zarozinski C. C., Welsh R. M. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185:1997;1629-1639.