Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 271, Issue 6 15-6, 1996, Pages

  Peters Golden, Marc ^a,b   Mcnish, Robert W ^a   Davis, Julie A ^a   Blackwood, R Alexander ^a   Brock, Thomas G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

adenosine 5' triphosphate; calcium; eicosanoids; microtubules

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIUM ION; COLCHICINE;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; FEMALE; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030445813     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.271.6.l1004     Document Type: Article

References (35)

1. Aderem, A. A., and Z. A. Cohn. Calcium ionophore synergizes with bacterial lipopolysaccharides in activating macrophage arachidonic acid metabolism. J. Exp. Med. 167: 623-631, 1988.
2. Allen, J. N., D. J. Herzyk, and M. D. Wewers. Colchicine has opposite effects on interleukin-1β and tumor necrosis factor-α production. Am. J. Physiol. 261 (Lung Cell. Mol. Physiol. 5): L315-L321, 1991.
3. Bigby, T. D., and M. J. Holtzman. Enhanced 5-lipoxygenase activity in lung macrophages compared to monocytes from normal subjects. J. Immunol. 138: 1546-1550, 1987.
4. Brock, T. G., R. W. McNish, and M. Peters-Golden. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J. Biol. Chem. 270: 21652-21658, 1995.
5. Brock, T. G., R. Paine, and M. Peters-Golden. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J. Biol. Chem. 269: 22059-22066, 1994.
6. Chou, I. N., J. Zeiger, and E. Rapaport. Imbalance of total cellular nucleotide pools and mechanism of the colchicine-induced cell activation. Proc. Natl. Acad. Sci. USA 81: 2401-2405, 1984.
7. 2 from the human monocytic cell line U937. Proc. Natl. Acad. Sci. USA 87: 7707-7712, 1990.
8. Coffey, M., M. Peters-Golden, J. Fantone, and P. Sporn. Membrane association of active 5-lipoxygenase in resting cells: evidence for novel regulation of the enzyme in the rat alveolar macrophage. J. Biol. Chem. 267: 570-576, 1992.
9. Cox, J., R. Snyderman, and J. Murray. Inhibition of 5-lipoxygenase translocation and activation in human neutrophils by microtubular disruption (Abstract). Clin. Res. 35: 472, 1987.
10. Drazen, J. Clinical studies with agents active on the 5-lipoxygenase pathway. Allergy 50: 22-26, 1995.
11. 2+ indicators with greatly improved fluorescent properties. J Biol. Chem. 260: 3440-3450, 1985.
12. Hashizume, T., S. Akiba, T. Sato, T. Fujii, S. Watanabe, and J. Sasaki. Vinblastine inhibits platelet aggregation by a microtubule-independent mechanism, probably by its perturbing action on the plasma membrane. Thromb. Res. 50: 181-190, 1988.
13. 4 synthesis and release. J. Immunol. 146: 692-700, 1991.
14. Kelly, S. J., A. J. Uri, H. S. Freeland, E. J. Woods, E. S. Schulman, S. P. Peters, and J. E. Fish. Effects of colchicine on IgE-mediated early and late airway reactions. Chest 107: 985-991, 1995.
15. 4 from alveolar macrophages of rats with silicosis. Am. J. Respir. Cell Mol. Biol. 7: 542-547, 1992.
16. Ochi, K., T. Yoshimoto, S. Yamamoto, K. Taniguchi, and T. Miyamoto. Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes: activation by adenosine 5′-triphosphate. J. Biol. Chem. 258: 5754-5758, 1983.
17. 4 by human polymorphonuclear leukocytes. Clin. Exp. Rheumatol. 7: 397-402, 1989.
18. Peters, S. G., J. C. McDougall, W. W. Douglas, D. T. Coles, and R. A. DeRemee. Colchicine in the treatment of pulmonary fibrosis. Chest 103: 101-104, 1993.
19. Peters-Golden, M., R. W. McNish, R. Hyzy, C. Shelly, and G. B. Toews. Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung. J. Immunol. 144: 263-270, 1990.
20. Phan, S., B. McGarry, K. Loeffler, and S. Kunkel. Regulation of macrophage-derived fibroblast growth factor release by arachidonate metabolites. J. Leukocyte Biol. 42: 106-113, 1987.
21. 2+ levels and phosphatidylcholine vesicles. Biochim. Biophys. Acta 960: 261-267, 1988.
22. Reibman, J., K. Haines, D. Gude, and G. Weissmann. Differences in signal transduction between Fcγ receptors (FcγRII, FcγRIII) and FMLP receptors in neutrophils. J. Immunol. 146: 988-996, 1991.
23. 4 by human neutrophils: the role of microtubules. J. Immunol. 136: 1027-1032, 1986.
24. Rennard, S., P. Bitterman, T. Ozaki, W. Rom, and R. Crystal. Colchicine suppresses the release of flbroblast growth factors from alveolar macrophages in vitro. Am. Rev. Respir. Dis. 137: 181-185, 1988.
25. Rudolph, S. A., P. Greengard, and S. E. Malawista. Effects of colchicine on cyclic AMP levels in human leukocytes. Proc. Natl. Acad. Sci. USA 72: 3404-3408, 1977.
26. Serhan, C. N., U. Lundberg, G, Weissmann, and B. Samuelsson, Formation of leukotrienes and hydroxy acids from human neutrophils and platelets exposed to monosodium urate. Prostaglandins 27: 563-581, 1984.
27. 4 during experimental inflammation. Biochem. Pharmacol 32: 1353-1359, 1983.
28. Sporn, P. H. S., and M. Peters-Golden. Hydrogen peroxide inhibits alveolar macrophage 5-lipoxygenase metabolism in association with depletion of ATP. J. Biol. Chem. 263: 14776-14783, 1988.
29. Stanley, P. E., and S. G. Williams. Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme. Anal. Biochem. 29: 381-392, 1969.
30. 2+ release from the intracellular Ca store of rat peritoneal mast cells. Agents Actions 33: 44-47, 1991.
31. Tripp, C. S., M. Mahoney, and P. Needleman. Calcium ionophore enables soluble agonists to stimulate macrophage 5-lipoxygenase. J. Biol. Chem. 260: 5895-5898, 1985.
32. Weinberg, J., M. Venkatachalam, N. Roeser, J. Davis, J. Varani, and K. Johnson. Amino acid protection of cultured kidney tubule cells against calcium ionophore-induced lethal cell injury. Lab. Invest. 65: 671-678, 1991.
33. 4, by human neutrophils activated with unopsonized zymosan. J. Immmunol. 134: 2624-2630, 1985.
34. Woods, J., M. Coffey, T. Brock, I. Singer, and M. Peters-Golden. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J. Clin. Invest. 95: 2035-2040, 1995.
35. Woods, J., J. Evans, D. Ethier, S. Scott, P. Vickers, L. Hearn, S. Charleson, J. Heibein, and I. Singer. 5-Lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. 178: 1935-1946, 1993.