IL-5 increases expression of 5-lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils

Journal of Immunology

Volumn 163, Issue 1, 1999, Pages 456-465

  Cowburn, Andrew S ^a   Holgate, Stephen T ^a   Sampson, Anthony P ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; INTERLEUKIN 5;

ALLERGIC ASTHMA; ARTICLE; BRONCHOSPASM; CELL NUCLEUS; CELLULAR DISTRIBUTION; ENZYME INDUCTION; ENZYME LOCALIZATION; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; ARACHIDONATE 5-LIPOXYGENASE; ASTHMA; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CALCIMYCIN; CARRIER PROTEINS; CELL NUCLEUS; CELLS, CULTURED; CYSTEINE; EOSINOPHILS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-5; LEUKOCYTE COUNT; LEUKOTRIENES; MALE; MEMBRANE PROTEINS; STAINING AND LABELING; SUBCELLULAR FRACTIONS;

EID: 0033168519     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Hay, D. W. P., T. J. Torphy, and B. J. Undem. 1995. Cysteinyl leukotrienes in asthma: old mediators up to new tricks. Trends Pharmacol. Sci. 16:304.
2. Holgate, S. T., P. Bradding, and A. P. Sampson. 1996. Leukotriene antagonists and synthesis inhibitors: new directions in asthma therapy. J. Allergy Clin. Immunol. 98:1.
3. 4 synthase in bronchial biopsies of aspirin-intolerant asthmatics. J. Clin. Invest. 101:834.
4. Seymour, M. L., D. Aberg, G. Riise, S. Rak, S. T. Holgate, and A. P. Sampson. 1998. Seasonal allergen exposure increases expression of leukotriene pathway enzymes and induces eosinophil influx in bronchial mucosa of atopic asthmatics. J. Allergy Clin. Immunol. 101:711 (Abstr.).
5. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65:1043.
6. Dixon, R. A., R. E. Diehl, E. Opas, E. Rands, P. J. Vickers, J. F. Evans, J. W. Gillard, and D. K. Miller. 1990. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343:282.
7. Woods, J. W., J. F. Evans, D. Ethier, S. Scott, P. J. Vickers, L. Hearn, J. A. Heibein, S. Charleson, and I. I. Singer. 1993. 5-Lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. 178:1935.
8. 4 synthase activities. Proc. Natl. Acad. Sci. USA 83:857.
9. 4 hydrolase in human leukocytes: purification and properties. J. Biol. Chem. 259: 12339.
10. 4 synthase of guinea pig lung. J. Clin. Invest. 81: 866.
11. 4 from eosinophils in asthmatic patients. Allergy 40: 571.
12. Bruijnzeel, P. L., J. C. J. Virchow, S. Rihs, C. Walker, and J. Verhagen. 1993. Lack of increased numbers of low-density eosinophils in the circulation of asthmatic individuals. Clin. Exp. Allergy 23:261.
13. 4 production in asthma of different severities. Eur. Respir. J. 8:1465.
14. Silberstein, D. S., W. F. Owen, J. C. Gasson, J. F. DiPersio, D. W. Golde, J. C. Bina, R. Soberman, K. F. Austen, and J. R. David. 1986. Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor. J. Immunol. 137:3290.
15. Rothenberg, M. E., W. F. Owen, D. S. Silberstein, J. Woods, R. J. Soberman, K. F. Austen, and R. L. Stevens. 1988. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J. Clin. Invest. 81:1986.
16. Rothenberg, M. E., J. Petersen, R. L. Stevens, D. S. Silberstein, D. T. McKenzie, K. F. Austen, and W. F. Owen. 1989. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J. Immunol. 143:2311.
17. 4 in response to soluble agonists. J. Immunol. 147:3855.
18. 4 synthesis. J. Immunol. 140:4315.
19. McColl, S. R., P. Di, A. C. Caon, P. Ho, and P. H. Naccache. 1991. Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor. Blood 78:1842.
20. Pouliot, M., P. P. McDonald, P. Borgeat, and S. R. McColl. 1994a. Granulocyte/macrophage colony-stimulating factor stimulates the expression of 5-lipoxygenase-activating protein (FLAP) in human neutrophils. J. Exp. Med. 179:1225.
21. Pouliot, M., P. P. McDonald, L. Khamzina, P. Borgeat, and S. R. McColl. 1994b. Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes. J. Immunol. 152:851.
22. Stankova, J., M. Rola-Pleszczynski, and C. M. Dubois. 1995. Granulocyte-macrophage colony-stimulating factor increases 5-lipoxygenase gene transcription and protein expression in human neutrophils. Blood 85:3719.
23. Ring, W. L., C. A. Riddick, J. R. Baker, D. A. Munato, and T. D. Bigby. 1996. Lymphocytes stimulate expression of 5-lipoxygenase and its activating protein in monocytes in vitro via granulocyte macrophage colony-stimulating factor and interleukin 3. J. Clin. Invest. 97:1293.
24. Ring, W. L., C. A. Riddick, J. R. Baker, C. K. Glass, and T. D. Bigby. 1997. Activated lymphocytes increase expression of 5-lipoxygenase and its activating protein in THP-1 cells. Am. J. Physiol. 273:C2057.
25. Coffey, M. J., S. E. Wilcoxen, and M. Peters-Golden. 1994. Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 11:153.
26. Woods, J. W., M. J. Coffey, T. G. Brock, I. I. Singer, and M. Peters-Golden. 1995. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J. Clin. Invest. 95:2035.
27. Brock, T. G., R. W. McNish, M. B. Bailie, and M. Peters-Golden. 1997. Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence. J. Biol. Chem. 272:8276.
28. Clutterbuck, E. J., E. M. Hirst, and C. J. Sanderson. 1989. Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GM-CSF. Blood 73:1504.
29. Lopez, A. F., C. J. Sanderson, J. R. Gamble, H. R. Campbell, I. G. Young, and M. A. Vadas. 1988. Recombinant interleukin-5 is a selective activator of human eosinophil function. J. Exp. Med. 167:219.
30. Walsh, G. M., A. Hartnell, A. J. Wardlaw, K. Kurihara, C. J. Sanderson, and A. B. Kay. 1990. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 71:258.
31. Fujisawa, T., R. Abu Ghazaleh, H. Kita, C. J. Sanderson, and G. J. Gleich. 1990. Regulatory effect of cytokines on eosinophil degranulation. J. Immunol. 144:642.
32. Bradding, P., J. A. Roberts, K. M. Britten, S. Mortefort, R. Djukanovic, R. Mueller, C. H. Heusser, P. H. Howarth, and S. T. Holgate. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am. J. Respir. Cell. Mol. Biol. 10:471.
33. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
34. Corrigan, C. J., A. Haczku, V. Gemou-Engesaeth, S. Doi, Y. Kikuchi, K. Takatsu, S. R. Durham, and A. B. Kay. 1993. CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of inlerleukin-5. Am. Rev. Respir. Dis. 147:540.
35. Chihara, J., J. Plumas, V. Gruart, J. Tavernier, L. Prin, A. Capron, and M. Capron. 1990. Characterization of a receptor for interleukin 5 on human eosinophils: variable expression and induction by granulocyte-macrophage colony-stimulating factor. J. Exp. Med. 172:1347.
36. Miyajima, A., A. L. Mui, T. Ogorochi, and K. Sakamaki. 1993. Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82: 1960.
37. 4 synthase during the development of eosinophils in vitro from cord blood progenitors. Blood 88:4338.
38. Djukanovic, R., J. W. Wilson, K. M. Britten, S. J. Wilson, A. F. Walls, W. R. Roche, P. H. Howarth, and S. T. Holgate. 1992. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Respir. Dis. 145:669.
39. Riddick, C. A., W. L. Ring, J. R. Baker, C. R. Hodulik, and T. D. Bigby. 1997. Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells. Eur. J. Biochem. 246:112.
40. Goppelt-Struebe, M., D. Schaefer, and A. J. Habenicht. 1997. Differential regulation of cyclo-oxygenase-2 and 5-lipoxygenase-activating protein (FLAP) expression by glucocorticoids in monocytic cells. Br. J. Pharmacol. 122:619.
41. 4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br. J. Pharmacol. 118:1727.
42. Bland, J. M., and D. G. Altman. 1986. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:301.
43. Hartnell, A., R. Moqbel, G. M. Walsh, B. Bradley, and A. B. Kay. 1990. Fcγ and CD11/CD18 receptor expression on normal density and low density human eosinophils. Immunology 69:264.
44. Scoggan, K. A., A. W. Ford-Hutchinson, and D. W. Nicholson. 1995. Differential activation of leukotriene biosynthesis by granulocyte-macrophage colony stimulating factor and interleukin-5 in an eosinophilic substrain of HL-60 cells. Blood 36:3507.
45. Bennett, C. F., M. Y. Chiang, B. P. Monia, and S. T. Crooke. 1993. Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells. Biochem. J. 289:33.
46. 3. Proc. Natl. Acad. Sci. USA 92:107.
47. Nassar, G. M., A. Montero, M. Fukunaga, and K. F. Badr. 1997. Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes. Kidney Int. 51:1520.
48. Kargman, S., and C. A. Rouzer. 1989. Studies on the regulation, biosynthesis, and activation of 5-lipoxygenase in differentiated HL-60 cells. J. Biol. Chem. 264: 13313.
49. 4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. J. Immunol. 162: 1669.
50. Van der Bruggen, T., E. Caldenhoven, D. Kanters, P. Coffer, J. A. M. Raaijmakers, J. W. J. Lammers, and L. Koenderman. 1995. Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1α. Blood 85:1442.
51. Van der Bruggen, T., D. Kanters, A.T. Tool, J. A. M. Raaijmakers, J. W. J. Lammers, A. J. Verhoeven, and L. Koenderman. 1998. Cytokine-induced protein tyrosine phosphorylation is essential for cytokine priming of human eosinophils. J. Allergy Clin. Immunol. 101:103.
52. Lepley, R. A., and F. A. Fitzpatrick. 1994. 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. J. Biol. Chem. 269:24163.
53. Lepley, R. A., D. T. Muakardin, and F. A. Fitzpatrick. 1996. Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase. J. Biol. Chem. 271:6179.
54. Peters-Golden, M., R. W. McNish, J. A. Davis, R. A. Blackwood, and T. G. Brock. 1996. Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages. Am. J. Physiol. 271:L1004.
55. Funk, C. D., S. Hoshiko, T. Matsumoto, O. Radmark, and B. Samuelsson. 1989. Characterization of the human 5-lipoxygenase gene. Proc. Natl. Acad. Sci. USA 86:2587.
56. Kennedy, B. P., R. E. Diehl, Y. Boie, M. Adam, and R. A. Dixon. 1991. Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP). J. Biol. Chem. 266:8511.
57. Hoshiko, S., O. Radmark, and B. Samuelsson. 1990. Characterization of the human 5-lipoxygenase promoter. Proc. Natl. Acad. Sci. USA 87:9073.
58. Peers, S. H., and R. J. Flower. 1990. The role of lipocortin in corticosteroid actions. Am. Rev. Respir. Dis. 141:S18.
59. Schleimer, R. P. 1993. An overview of glucocorticoid anti-inflammatory actions. Eur. J. Clin. Pharmacol. 45 (Suppl. 1):S3.
60. Koehler, L., R. Hass, D. L. DeWitt, K. Resch, and M. Goppelt-Struebe. 1990. Glucocorticoid-induced reduction of prostanoid synthesis in TPA-differentiated U937 cells is mainly due to a reduced cyclooxygenase activity. Biochem. Pharmacol. 40:1307.
61. Manso, G., A. J. Baker, I. K. Taylor, and R. W. Fuller. 1992. In vivo and in vitro effects of glucocorticoids on arachidonic acid metabolism and monocyte function in nonasthmatic humans. Eur. Respir. J. 5:712.
62. Dworski, R., G. A. Fitzgerald, J. A. Oates, and J. R. Sheller. 1994. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. Am. J. Respir. Crit. Care Med. 149:953.
63. Brown, P. H., G. K. Crompton, and A. P. Greening. 1991. Proinflammatory cytokines in acute asthma. Lancet 338:590.