Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons

Journal of Physiology

Volumn 542, Issue 1, 2002, Pages 273-286

  Gao, Xiao Bing ^a   Van Den Pol, Anthony N ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MELANIN CONCENTRATING HORMONE; PEPTIDE HORMONE; PERTUSSIS TOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; ATTENUATION; BRAIN NERVE CELL; BRAIN SLICE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; DESENSITIZATION; DOSE RESPONSE; ELECTRIC POTENTIAL; EMBRYO; EVOKED RESPONSE; FEMALE; HORMONE ACTION; IC 50; LATERAL HYPOTHALAMUS; NERVE CELL CULTURE; NERVE CELL INHIBITION; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; ANIMAL TISSUE; CONCENTRATION (PARAMETERS); HYPOTHALAMIC SLICE; WHOLE CELL PATCH CLAMP;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, P-TYPE; CELLS, CULTURED; FEMALE; GTP-BINDING PROTEINS; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; IMAGE PROCESSING, COMPUTER-ASSISTED; MELANINS; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; PITUITARY HORMONES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 0036661122     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.019372     Document Type: Article

References (70)

1. ABEL, T., NGUYEN, P. V., BARAD, M., DEUEL, T. A., KANDEL, E. R. & BOURTCHOULADZE, R. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based longterm memory. Cell 88, 615-626.
2. AHLIJANIAN, M. K., WESTENBROEK, R. E. & CATTERALL, W. A. (1990). Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina. Neuron 4, 819-832.
3. 2+ currents in rod and cone photoreceptors of the salamander retina. Journal of Neuroscience 20, 929-936.
4. AMICO, C., MARCHETI, C., NOBILE, M & USAI, C. (1995). Pharmacological types of calcium channels and their modulation by baclofen in cerebellar granules. Journal of Neuroscience 15, 2839-2848.
5. BÄCHNER, D., KREIENKAMP, H., WEISE, C., BUCK, F. & RICHTER, D. (1999). Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1). FEBS Letters 457, 522-524.
6. BADING, H., GINTY, D. D. & GREENBERG, M. E. (1993). Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260, 181-186.
7. BEAUMONT, V., HEPWORTH, M. B., LUTY, J.- S., KELLY, E. & HENDERSON, G. (1998). Somatostatin receptor desensitization in NG108-15 cells. Journal of Biological Chemistry 273, 33174-33183.
8. BITTENCOURT, J. C., PRESSE, F., ARIAS, C., PETO, C., VAUGHAN, J., NAHON, J. -L., VALE, W. & SAWCHENKO, P. E. (1992). The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. Journal of Comparative Neurology 319, 218-245.
9. BLEAKMAN, D., HARRISON, N. L., COLMERS, W. F. & MILLER, R. J. (1992). Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat. British Journal of Pharmacology 107, 334-340.
10. CARAFOLI, E. GENASSANI, A. & GUERINI, D. (1999). Calcium controls the transcription of its own transporters and channels in developing neurons. Biochemical and Biophysical Research Communications 266, 625-632.
11. 2+ channels and their role in neurotransmitter release. Cell Calcium 24, 307-323.
12. 2+ channels. Annual Review of Cell and Developmental Biology 16, 521-555.
13. CHAMBERS, J., AMES, R. S., BERGSMA, D., MUIR, A., FITZGERALD, L. R., HERVIEU, G., DYTKO, G. M., FOLEY, J. J., MARTIN, J., LIU, W. S., PARK, J., ELLIS, C., GANGULY, S., KONCHAR, S., CLUDERAY, J., LESLIE, R., WILSON, S. & SARAU, H. M. (1999). Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400, 261-265.
14. CHEN, G. & VAN DEN POL, A. N. (1996). Multiple NPY receptors coexist in pre- and postsynaptic sites: inhibition of GABA release in isolated self-innervating SCN neurons. Journal of Neuroscience 16, 7711-7724.
15. CHEN, G. & VAN DEN POL, A. N. (1998). Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons. Journal of Neuroscience 18, 1913-1922.
16. CHIOCCHIO, S. R., GALLARDO, M. G., LOUZAN, P., GUTNISKY, V. & TRAMEZZANI, J. H. (2001). Melanin-concentrating hormone stimulates the release of luteinizing hormone-releasing hormone and gonadotropins in the female rat acting at both median eminence and pituitary levels. Biology of Reproduction 64, 1466-1472.
17. DASCAL, N. (2001). Ion-channel regulation by G proteins. Trends in Endocrinology and Metabolism 12, 391-398.
18. 2+ channel Cav1.2. Science 293, 98-101.
19. DE LECEA, L., KILDUFF, T. S., PEYRON, C., GAO, X., FOYE, P. E., DANIELSON, P. E., FUKUHARA, C., BATTENBERG, E. L., GAUTVIK, V. T., BARTLETT, F. S. 2ND, FRANKEL, W. N., VAN DEN POL, A. N., BLOOM, F. E., GAUTVIK, K. M. & SUTCLIFFE, J. G. (1998). The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences of the United States of America 95, 322-327.
20. 2+ channel inhibition. Neuron 16, 579-585.
21. ELLIOTT, E. M., MALOUF, A. T., CATTERALL, W. A. (1995). Role of calcium channel subtypes in calcium transients in hippocampal CA3 neurons. Journal of Neuroscience 15, 6433-6444.
22. GAO, X. B. & VAN DEN POL, A. N. (1999). Neurotrophin-3 potentiates excitatory GABAergic synaptic transmission in cultured developing hypothalamic neurones of the rat. Journal of Physiology 518, 81-95.
23. GAO, X. B., VAN DEN POL, A. N. (2001). Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. Journal of Physiology 533, 237-252.
24. GRAY, R. & JOHNSTON, D. (1987). Noradrenaline and beta-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurons. Nature 327, 620-622.
25. GROSS, R. A., UHLER, M. D. & MACDONALD, R. L. (1990). The cyclic AMP-dependent protein kinase catalytic subunit selectively enhances calcium currents in rat nodose neurones. Journal of Physiology 429, 483-496.
26. HARAYAMA, N., SHIBUYA, L, TANAKA, K., KABASHIMA, N., UETA, Y. & YAMASHITA, H. (1998). Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor activation in rat supraoptic neurones. Journal of Physiology 509, 371-383.
27. 2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein. Journal of Neuroscience 13, 1148-1156.
28. HILL, J., DUCKWORTH, M., MURDOCK, P., RENNIE, G., SABIDO-DAVID, C., AMES, R. S., SZEKERES, P., WILSON, S., BERGSMA, D. J., GLOGER, I. S., LEVY, D. S., CHAMBERS, J. K. & MUIR, A. I. (2001). Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. Journal of Biological Chemistry 276, 20125-20129.
29. HILLE, B. (1994). Modulation of ion-channel function by G-protein-coupled receptors. Trends in Neuroscience 17, 531-536.
30. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 239, 57-61.
31. ob mice. Neuroendocrinology 69, 145-153.
32. 2+ channels by gbeta gamma and calmodulin via interactions with N and C termini of alpha 1C. Journal of Biological Chemistry 275, 39846-39854.
33. KEJA, J. A & KITS, K. S. (1994). Voltage dependence of G-protein-mediated inhibition of high-voltage-activated calcium channels in rat pituitary melanotropes. Neuroscience 62, 281-289.
34. KILDUFF, T. S. & DE LECEA, L. (2001). Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems. Journal of Comparative Neurology 435, 1-5.
35. KLEUSS, C., HESCHELER, J., EWEL, C., ROSENTHAL, W., SCHULTZ, G. & WITTIG, B. (1991). Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353, 43-48.
36. LEMBO, P. M., GRAZZINI, E., CAO, J., HUBATSCH, D. A., PELLETIER, M., HOFFERT, C., ST-ONGE, S., POU, C., LABRECQUE, J., GROBLEWSKI, T., O'DONNELL, D., PAYZA, K., AHMAD, S. & WALKER, P. (1999). The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nature Cell Biology 1, 267-271.
37. LUDWIG, D. S., TRITOS, N. A., MASTAITIS, J. W., KULKARNI, R., KOKKOTOU, E., ELMQUIST, J., LOWELL, B., FLIER, J. S. & MARATOS-FLIER, E. (2001). Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. Journal of Clinical Investigation 107, 379-386.
38. MAGUIRE, G., MAPLE, B., LUKASIEWICZ, P. & WERBLIN, F. (1989). Gamma-aminobutyrate type B receptor modulation of L-type calcium channel current at bipolar cell terminal in the retina of the tiger salamander. Proceedings of the National Academy of Sciences of the United States of America 86, 10144-10147.
39. MONZON, M. E., DE SOUZA, M. M., IZQUIERDO, L. A., IZQUIERDO, L, BARROS, D. M. & DE BARIOGLIO S. R. (1999). Melanin-concentrating hormone (MCH) modifies memory retention in rats. Peptides 20, 1517-1519.
40. MORI, M., HARADA, M., TERAO, Y., SUGO, T., WATANABE, T., SHIMOMURA, Y., ABE, M., SHINTANI, Y., ONDA, H., NISHIMURA, O. & FUJINO, M. (2001). Cloning of a novel g protein-coupled receptor, slt, a subtype of the melanin-concentrating hormone receptor. Biochemical and Biophysical Research Communications 283, 1013-1018.
41. 2+ channel inhibition and its desensitization in NG108-15 cells. European Journal of Pharmacology 351, 247-252.
42. MURPHY, T. H., WORLEY, P. F. & BARABAN, J. M. (1991). L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron 7, 625-635.
43. NOMURA, K., REUVENY, E. & NARAHASHI, T. (1994). Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons. Journal of Pharmacology and Experimental Therapeutics 270, 466-474.
44. QU, D., LUDWIG, D. S., GRAMMELTPFT, S., PIPER, M., PELLEYMOUNTER, M. A., CULLEN, M. J., MATHES, W. F., PRZYPEK, J., KANAREK, R. & MARATOS-FLIER, E. (1996). A role of melanin-concentrating hormone in the central regulation of feeding behavior. Nature 380, 243-247.
45. RAJADHYAKSHA, A., BARCZAK, A., MACIAS, W., LEVEQUE, J. C., LEWIS, S. E. & KONRADI, C. (1999). L-Type Ca(2+). channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. Journal of Neuroscience 19, 6348-6359.
46. 2+ channel currents in rat cerebellar granule neurons. Journal of Neuroscience 15, 2995-3012.
47. ROLLS, E. T., MURZI, E., YAXLEY, S., THORPE, S. J. & SIMPSON, S. J. (1986). Sensory-specific satiety: food-specific reduction in responsiveness of ventral forebrain neurons after feeding in the monkey. Brain Research 368, 79-86.
48. ROSSI, M., CHOI, S. J., O'SHEA, D., MIYOSHI, T., GHATEI, M. A. & BLOOM, S. R. (1997). Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138, 351-355.
49. SAILER, A. W., SANO, H., ZENG, Z., MCDONALD, T. P., PAN, J., PONG, S. S., FEIGHNER, S. D., TAN, C. P., FUKAMI, T., IWAASA, H., HRENIUK, D. L., MORIN, N. R., SADOWSKI, S. J., ITO, M., ITO, M., BANSAL, A., KY, B., FIGUEROA, D. J., JIANG, Q., AUSTIN, C. P., MACNEIL, D. J., ISHIHARA, A., IHARA, M., KANATANI, A., VAN DER PLOEG, L. H., HOWARD, A. D. & LIU, Q. (2001). Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proceedings of the National Academy of Sciences of the United States of America 98, 7546-7569.
50. SAITO, Y., CHENG, M., LESLIE, F. M. & CIVELLI, O. (2001). Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. Journal of Comparative Neurology 435, 26-40.
51. SAITO, Y., NOTHACKER, H. P. & CIVELLI, O. (2000). Melanin-concentrating hormone receptor: an orphan receptor fits the key. Trends in Endocrinology and Metabolism 11, 299-303.
52. SAITO, Y., NOTHACKER, H. P., WANG, Z., LIN, S. H., LESLIE, F. & CIVELLI, O. (1999). Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400, 265-269.
53. SAWCHENKO, P. E. (1998). Toward a new neurobiology of energy balance, appetite, and obesity: the anatomists weigh in. Journal of Comparative Neurology 402, 435-441.
54. SAYER, R. J., SCHWINDT, P. C. & CRILL, W. E. (1992). Metabotropic glutamate receptor-mediated suppression of L-type calcium current in acutely isolated neocortical neurons. Journal of Neurophysiology 68, 833-842.
55. 2+ channels by using knockout mice. Proceedings of the National Academy of Sciences of the United States of America 96, 10899-10904.
56. SHIMADA, M., TRITOS, N. A., LOWELL, B. B., FLIER, L. S. & MARATOS-FLIER, E. (1998). Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670-674.
57. SIDACH, S. S. & MINTZ, I. M. (2000). Low-affinity blockade of neuronal N-type Ca channels by the spider toxin ω-agatoxin-IVA. Journal of Neuroscience 20, 7174-7182.
58. 2+ channels in rat thalamic neurons. Journal of Physiology 531, 67-79.
59. TROMBLEY, P. Q. (1992). Norepinephrine inhibits calcium currents and EPSPs via a G-protein-coupled mechanism in olfactory bulb neurons. Journal of Neuroscience 12, 3992-3998.
60. 2+ channel types coexist to regulate synaptosomal neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America 90, 9518-9522.
61. VAN DEN POL, A. N., GAO, X. B., OBRIETAN, K., KILDUFF, T. S. & BELOUSOV, A. B. (1998). Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. Journal of Neuroscience 18, 7962-7971.
62. VAN DEN POL, A. N., OBRIETAN, K., CHEN, G. & BELOUSOV, A. B. (1996). Neuropeptide Y-mediated long-term depression of excitatory activity in suprachiasmatic nucleus neurons. Journal of Neuroscience 16, 5883-5895.
63. VAN DEN POL, A. N., PATRYLO, P. R., GHOSH, P. K. & GAO, X. B. (2001). Lateral hypothalamus early developmental expression and response to hypocretin (orexin). Journal of Comparative Neurology 433, 349-363.
64. VIALE, A., KERDELHUE, B. & NAHON, J. L. (1999). 17 beta-estradiol regulation of melanin-concentrating hormone and neuropeptide-E-I contents in cynomolgus monkeys: a preliminary study. Peptides 20, 553-559.
65. VIANA, F. & HILLE, B. (1996). Modulation of high voltage-activated calcium channels by somatostatin in acutely isolated rat amygdaloid neurons. Journal of Neuroscience 16, 6000-6011.
66. 2+ channels at the base of major dendrites in hippocampal pyramidal neurons. Nature 347, 281-284.
67. WESTENBROEK, R. E., HELL, J. W., WARNER, C., DUBEL, S. J., SNUTCH, T. P. & CATTERALL, W. A. (1992). Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit. Neuron 9, 1099-1115.
68. WESTENBROEK, R. E., SAKURAI, T., ELLIOTT, E. M., HELL, J. W., STARR, T. V., SNUTCH, T. P. & CATTERALL, W. A. (1995). Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels. Journal of Neuroscience 10, 6403-6418.
69. 2+ channels in supporting hippocampal synaptic transmission. Science 264, 107-111.
70. ZIELHOFER, H. U., MULLER, T. H. & SWANDULLA, D. (1996). Calcium channel types contributing to excitatory and inhibitory synaptic transmission between individual hypothalamic neurons. Pflügers