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Volumn 56, Issue 3, 2002, Pages 452-457

Use of vitamin C and E in the treatment of Alzheimer's disease

Author keywords

Alzheimer's disease; Antioxidants; Lipid peroxidation; Therapy

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; SELEGILINE;

EID: 0036660259     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10107     Document Type: Review
Times cited : (8)

References (45)
  • 1
    • 0033977413 scopus 로고    scopus 로고
    • Time-course of oxidation of lipids in human cerebrospinal fluid in vitro
    • Arlt S, Finckh B, Beisiegel U, Kontush A. 2000. Time-course of oxidation of lipids in human cerebrospinal fluid in vitro. Free Radic Res 32:103-114.
    • (2000) Free Radic Res , vol.32 , pp. 103-114
    • Arlt, S.1    Finckh, B.2    Beisiegel, U.3    Kontush, A.4
  • 2
    • 0035985698 scopus 로고    scopus 로고
    • Lipid peroxidation in neurodegeneration: New insights into Alzheimer's disease
    • Arlt S, Beisiegel U, Kontush A. 2002. Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease. Curr Opin Lipidol 13:289-294.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 289-294
    • Arlt, S.1    Beisiegel, U.2    Kontush, A.3
  • 3
    • 0034186642 scopus 로고    scopus 로고
    • Vitamin E supplementation increases the resistance of both LDL and HDL to oxidation and increases cholesteryl ester transfer activity
    • Arrol S, Mackness MI, Durrington PN. 2000. Vitamin E supplementation increases the resistance of both LDL and HDL to oxidation and increases cholesteryl ester transfer activity. Atherosclerosis 150:129-134.
    • (2000) Atherosclerosis , vol.150 , pp. 129-134
    • Arrol, S.1    Mackness, M.I.2    Durrington, P.N.3
  • 4
    • 0033374599 scopus 로고    scopus 로고
    • Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo
    • Bassett CN, Neely MD, Sidell KB, Markesbery WB, Swift LL, Montine TJ. 1999. Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo. Lipids 34:1273-1280.
    • (1999) Lipids , vol.34 , pp. 1273-1280
    • Bassett, C.N.1    Neely, M.D.2    Sidell, K.B.3    Markesbery, W.B.4    Swift, L.L.5    Montine, T.J.6
  • 5
  • 6
    • 0028917535 scopus 로고
    • The health effects of vitamin C supplementation: A review
    • Bendich A, Langseth L. 1995. The health effects of vitamin C supplementation: a review. J Am Coll Nutr 14:124-136.
    • (1995) J Am Coll Nutr , vol.14 , pp. 124-136
    • Bendich, A.1    Langseth, L.2
  • 7
    • 0034035616 scopus 로고    scopus 로고
    • Metals and neuroscience
    • Bush AI. 2000. Metals and neuroscience. Curr Opin Chem Biol 4:184-191.
    • (2000) Curr Opin Chem Biol , vol.4 , pp. 184-191
    • Bush, A.I.1
  • 8
    • 0342547342 scopus 로고    scopus 로고
    • Graded dietary levels of RRR-gamma-tocopherol induce a marked increase in the concentrations of alpha- and gamma-tocopherol in nervous tissues, heart, liver, and muscle of vitamin-E-deficient rats
    • Clement M, Bourre JM. 1997. Graded dietary levels of RRR-gamma-tocopherol induce a marked increase in the concentrations of alpha- and gamma-tocopherol in nervous tissues, heart, liver, and muscle of vitamin-E-deficient rats. Biochim Biophys Acta 1334:173-181.
    • (1997) Biochim Biophys Acta , vol.1334 , pp. 173-181
    • Clement, M.1    Bourre, J.M.2
  • 9
    • 0026636491 scopus 로고
    • A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease
    • Fahn S. 1992. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease. Ann Neurol 32 (suppl):S128-S132.
    • (1992) Ann Neurol , vol.32 , Issue.SUPPL.
    • Fahn, S.1
  • 10
    • 0001218860 scopus 로고
    • Ascorbate is an outstanding antioxidant in human blood plasma
    • Frei B, England L, Ames BN. 1989. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86:6377-6381.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6377-6381
    • Frei, B.1    England, L.2    Ames, B.N.3
  • 11
    • 0033958696 scopus 로고    scopus 로고
    • Vitamin E and Alzheimer disease: The basis for additional clinical trials
    • Grundman M. 2000. Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr 71:630S-636S.
    • (2000) Am J Clin Nutr , vol.71
    • Grundman, M.1
  • 12
    • 0032904130 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease
    • Kalaria RN. 1999. Microglia and Alzheimer's disease. Curr Opin Hematol 6:15-24.
    • (1999) Curr Opin Hematol , vol.6 , pp. 15-24
    • Kalaria, R.N.1
  • 13
    • 0034904940 scopus 로고    scopus 로고
    • Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta
    • Kolsch H, Ludwig M, Lutjohann D, Rao ML. 2001. Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. J Neural Transm 108:475-488.
    • (2001) J Neural Transm , vol.108 , pp. 475-488
    • Kolsch, H.1    Ludwig, M.2    Lutjohann, D.3    Rao, M.L.4
  • 14
    • 0003193332 scopus 로고    scopus 로고
    • Measurement of oxidizability of blood plasma
    • Kontush A, Beisiegel U. 1999. Measurement of oxidizability of blood plasma. Methods Enzymol 49:29935-29949.
    • (1999) Methods Enzymol , vol.49 , pp. 29935-29949
    • Kontush, A.1    Beisiegel, U.2
  • 15
  • 17
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • Lovell MA, Ehmann WD, Butler SM, Markesbery WR. 1995. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45:1594-1601.
    • (1995) Neurology , vol.45 , pp. 1594-1601
    • Lovell, M.A.1    Ehmann, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 18
    • 0035112495 scopus 로고    scopus 로고
    • Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
    • Lovell MA, Xie C, Markesbery WR. 2001. Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiol Aging 22:187-194.
    • (2001) Neurobiol Aging , vol.22 , pp. 187-194
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 19
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • Markesbery WR. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23:134-147.
    • (1997) Free Radic Biol Med , vol.23 , pp. 134-147
    • Markesbery, W.R.1
  • 20
    • 0031980065 scopus 로고    scopus 로고
    • Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
    • Markesbery WR, Lovell MA. 1998. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiol Aging 19:33-36.
    • (1998) Neurobiol Aging , vol.19 , pp. 33-36
    • Markesbery, W.R.1    Lovell, M.A.2
  • 21
    • 0034834620 scopus 로고    scopus 로고
    • Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde
    • McGrath LT, McGleenon BM, Brennan S, McColl D, McILroy S, Passmore AP. 2001. Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde. QJM 94:485-490.
    • (2001) QJM , vol.94 , pp. 485-490
    • McGrath, L.T.1    McGleenon, B.M.2    Brennan, S.3    McColl, D.4    McILroy, S.5    Passmore, A.P.6
  • 22
    • 0023722150 scopus 로고
    • Effect of dietary vitamin E and selenium on susceptibility of brain regions to lipid peroxidation
    • Meydani M, Macauley JB, Blumberg JB. 1988. Effect of dietary vitamin E and selenium on susceptibility of brain regions to lipid peroxidation. Lipids 23:405-409.
    • (1988) Lipids , vol.23 , pp. 405-409
    • Meydani, M.1    Macauley, J.B.2    Blumberg, J.B.3
  • 24
    • 0031028437 scopus 로고    scopus 로고
    • Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4
    • Montine KS, Olson SJ, Amarnath V, Whetsell WO, Jr., Graham DG, Montine TJ. 1997. Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. Am J Pathol 150:437-443.
    • (1997) Am J Pathol , vol.150 , pp. 437-443
    • Montine, K.S.1    Olson, S.J.2    Amarnath, V.3    Whetsell W.O., Jr.4    Graham, D.G.5    Montine, T.J.6
  • 26
    • 0033006380 scopus 로고    scopus 로고
    • The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin
    • Neely MD, Sidell KR, Graham DG, Montine TJ. 1999. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. J Neurochem 72:2323-2333.
    • (1999) J Neurochem , vol.72 , pp. 2323-2333
    • Neely, M.D.1    Sidell, K.R.2    Graham, D.G.3    Montine, T.J.4
  • 27
    • 0034900835 scopus 로고    scopus 로고
    • The role of vitamin E in atherogenesis: Linking the chemical, biological and clinical aspects of the disease
    • Neuzil J, Weber C, Kontush A. 2001. The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease. Atherosclerosis 157:257-283.
    • (2001) Atherosclerosis , vol.157 , pp. 257-283
    • Neuzil, J.1    Weber, C.2    Kontush, A.3
  • 28
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disibility in early Parldnson's disease
    • Parkinson Study Group. 1993. Effects of tocopherol and deprenyl on the progression of disibility in early Parldnson's disease. N Engl J Med 328:176-183.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 29
    • 0035857493 scopus 로고    scopus 로고
    • Acrolein inhibits respiration in isolated brain mitochondria
    • Picklo MJ, Montine TJ. 2001. Acrolein inhibits respiration in isolated brain mitochondria. Biochim Biophys Acta 1535:145-152.
    • (2001) Biochim Biophys Acta , vol.1535 , pp. 145-152
    • Picklo, M.J.1    Montine, T.J.2
  • 30
    • 0032238783 scopus 로고    scopus 로고
    • Increased F2-isoprostanes in Alzheimer's disease: Evidence for enhanced lipid peroxidation in vivo
    • Pratico D, Lee VMY, Trojanowski JQ, Rokach J, FitzGerald GA. 1998. Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo. FASEB J 12:1777-1783.
    • (1998) FASEB J , vol.12 , pp. 1777-1783
    • Pratico, D.1    Lee, V.M.Y.2    Trojanowski, J.Q.3    Rokach, J.4    FitzGerald, G.A.5
  • 31
    • 0027279397 scopus 로고
    • Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate
    • Reiber H, Ruff M, Uhr M. 1993. Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate. Clin Chim Acta 217:163-173.
    • (1993) Clin Chim Acta , vol.217 , pp. 163-173
    • Reiber, H.1    Ruff, M.2    Uhr, M.3
  • 32
    • 0034194081 scopus 로고    scopus 로고
    • Ascorbate regulation and its neuroprotective role in the brain
    • Rice ME. 2000. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 23:209-216.
    • (2000) Trends Neurosci , vol.23 , pp. 209-216
    • Rice, M.E.1
  • 33
    • 0027365482 scopus 로고
    • Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins
    • Rifici VA, Khachadurian AK. 1993. Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins. J Am Coll Nutr 12:631-637.
    • (1993) J Am Coll Nutr , vol.12 , pp. 631-637
    • Rifici, V.A.1    Khachadurian, A.K.2
  • 36
    • 0035003439 scopus 로고    scopus 로고
    • Chemistry and biochemistry of oxidative stress in neurodegenerative disease
    • Sayre LM, Smith MA, Perry G. 2001. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8:721-738.
    • (2001) Curr Med Chem , vol.8 , pp. 721-738
    • Sayre, L.M.1    Smith, M.A.2    Perry, G.3
  • 37
    • 0030989545 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
    • Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA. 1997. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68:2092-2097.
    • (1997) J Neurochem , vol.68 , pp. 2092-2097
    • Sayre, L.M.1    Zelasko, D.A.2    Harris, P.L.3    Perry, G.4    Salomon, R.G.5    Smith, M.A.6
  • 41
    • 0033751421 scopus 로고    scopus 로고
    • Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease
    • Smith MA, Nunomura A, Zhu X, Takeda A, Perry G. 2000. Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxid Redox Signal 2:413-420.
    • (2000) Antioxid Redox Signal , vol.2 , pp. 413-420
    • Smith, M.A.1    Nunomura, A.2    Zhu, X.3    Takeda, A.4    Perry, G.5
  • 42
    • 0015831449 scopus 로고
    • Ascorbic acid homeostasis in the central nervous system
    • Spector R, Lorenzo AV. 1973. Ascorbic acid homeostasis in the central nervous system. Am J Physiol 225:751-763.
    • (1973) Am J Physiol , vol.225 , pp. 751-763
    • Spector, R.1    Lorenzo, A.V.2
  • 43
    • 0030799043 scopus 로고    scopus 로고
    • Low density lipoprotein oxidation and its pathobiological significance
    • Steinberg D. 1997. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 272:20963-20966.
    • (1997) J Biol Chem , vol.272 , pp. 20963-20966
    • Steinberg, D.1
  • 44
    • 0028556264 scopus 로고
    • Lipoprotein oxidation: Mechanistic aspects, methodological approaches and clinical relevance
    • Stocker R. 1994. Lipoprotein oxidation: mechanistic aspects, methodological approaches and clinical relevance. Curr Opin Lipidol 5:422-433.
    • (1994) Curr Opin Lipidol , vol.5 , pp. 422-433
    • Stocker, R.1
  • 45
    • 0031666630 scopus 로고    scopus 로고
    • Vitamin E and other endogenous antioxidants in the central nervous system
    • Vatassery GT. 1998. Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics 53 (suppl 1):S25-S27.
    • (1998) Geriatrics , vol.53 , Issue.SUPPL. 1
    • Vatassery, G.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.