Toxicogenomics: A new revolution in drug safety

Drug Discovery Today

Volumn 7, Issue 13, 2002, Pages 728-736

  Castle, Arthur L ^a   Carver, Michael P ^b   Mendrick, Donna L ^a  

^a Gene Logic   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; DONEPEZIL; PARACETAMOL; PHYSOSTIGMINE SALICYLATE; TACRINE; DRUG;

ALZHEIMER DISEASE; ANALYTIC METHOD; CLASSIFICATION; CLINICAL TRIAL; CLUSTER ANALYSIS; COST; DNA MICROARRAY; DRUG MARKETING; DRUG SAFETY; DRUG SCREENING; EXPOSURE; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC ANALYSIS; GENOMICS; GENOTOXICITY; HUMAN; LIVER TOXICITY; MARKER GENE; MULTIVARIATE ANALYSIS; NONHUMAN; PREDICTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RISK ASSESSMENT; SAMPLING; TOXICITY; TOXICOLOGY; ANIMAL; ANIMAL MODEL; ARTIFICIAL NEURAL NETWORK; SAFETY; STANDARD;

ANIMAL; GENOMICS; HUMAN; MODELS, ANIMAL; NEURAL NETWORKS (COMPUTER); PHARMACEUTICAL PREPARATIONS; SAFETY; TOXICOLOGY; ANIMALS; HUMANS;

EID: 0036629243     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02327-9     Document Type: Review

References (69)

1. Statistical design and the analysis of gene expression microarray data
2. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
3. Pattern recognition of genomic features with microarrays: Site typing of Mycobacterium tuberculosis strains
4. A nonparametric scoring algorithm for identifying informative genes from microarray data
5. Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experiments
6. Microarray expression profiling identifies genes with altered expression in HDL-deficient mice
7. Determining significant fold differences in gene expression analysis
8. On reporting fold differences
9. Generation of patterns from gene expression data by assigning confidence to differentially expressed genes
10. Computational methods for the identification of differential and coordinated gene expression
11. The application of shannon entropy in the identification of putative drug targets
12. 'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns
13. Exploring the metabolic and genetic control of gene expression on a genomic scale
14. A genome-wide transcriptional analysis of the mitotic cell cycle
15. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization
16. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
17. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
18. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
19. Support vector machine classification and validation of cancer tissue samples using microarray expression data
20. Towards a novel classification of human malignancies based on gene expression patterns
21. Molecular classification of cutaneous malignant melanoma by gene expression profiling
22. Analysis of gene expression microarrays for phenotype classification
23. Principal components analysis to summarize microarray experiments: Application to sporulation time series
24. Knowledge-based analysis of microarray gene expression data by using support vector machines
25. Basic microarray analysis: Grouping and feature reduction
26. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
27. Biclustering of expression data
28. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
29. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles
30. Systematic analysis of DNA microarray data: Ordering and interpreting patterns of gene expression
31. Cluster analysis and display of genome-wide expression patterns
32. Cluster analysis and data visualization of large-scale gene expression data
33. Analysis of large-scale gene expression data
34. Exploring expression data: Identification and analysis of coexpressed genes
35. Microarray analysis of trophoblast differentiation: Gene expression reprogramming in key gene function categories
36. Effects of ischemia on gene expression
37. J-Express: Exploring gene expression data using Java
38. Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation
39. Analysis of gene expression data using self-organizing maps
40. Whole-genome expression analysis: Challenges beyond clustering
41. Validating clustering for gene expression data
42. Circuit simulation of genetic networks
43. Development of a system for the inference of large scale genetic networks
44. Linear modeling of genetic networks from experimental data
45. Using graphical models and genomic expression data to statistically validate models of genetic regulatory networks
46. Linear modeling of mRNA expression levels during CNS development and injury
47. A comparison of genetic network models
48. Algorithms for identifying Boolean networks and related biological networks based on matrix multiplication and fingerprint function
49. Inferring qualitative relations in genetic networks and metabolic pathways
50. Reveal, a general reverse engineering algorithm for inference of genetic network architectures
51. Reverse engineering of metabolic pathways from observed data using genetic programming
52. READS: A method for display of 3¢-end fragments of restriction enzyme-digested cDNAs for analysis of differential gene expression
53. High-throughput gene expression analysis for drug discovery
54. Analysis of differential gene expression by display of 3¢ end restriction fragments of cDNAs
55. Application of complementary DNA microarray technology to carcinogen identification, toxicology and drug safety evaluation
56. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
57. Genomics and proteomics. The new millennium of drug discovery and development
58. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays
59. Predictive modeling of hepatotoxicants using microarrays and a linear discriminant modeling approach
60. Cross compound predictions using gene expression profiles from acetaminophen or carbon tetrachloride, two structurally distinct liver toxicants
61. Treatment of Alzheimer's disease
62. Cholinesterase inhibitors in the treatment of Alzheimer's Disease. A comparison of tolerability and pharmacology
63. Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference
64. Long-term oral administration of memory-enhancing doses of tacrine in mice: A study of potential toxicity and side effects
65. Identification through gene expression of a toxic response in the rat for a compound that exhibits overt toxicity in humans, but not in rats
66. Describing the validity of carcinogen screening tests
67. Screening toxic chemicals: How accurate must tests be?