The application of Shannon entropy in the identification of putative drug targets

BioSystems

Volumn 55, Issue 1-3, 2000, Pages 5-14

  Fuhrman, Stefanie ^a   Cunningham, Mary Jane ^a   Wen, Xiling ^a   Zweiger, Gary ^a   Seilhamer, Jeffrey J ^a   Somogyi, Roland ^a  

^a Experimental Station   (United States)

Author keywords

Drug development; Gene expression; Genomics; Information theory; Microarrays; PCR

Indexed keywords

BENZO[A]PYRENE; CLOFIBRATE; DNA; MESSENGER RNA; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; COMPUTER; CONFERENCE PAPER; CONTROLLED STUDY; DATA BASE; DRUG DEVELOPMENT; DRUG TARGETING; ENTROPY; GENE EXPRESSION; GENOME; INFORMATION SCIENCE; MALE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; TECHNIQUE;

EID: 0034100903     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-2647(99)00077-5     Document Type: Article

References (8)

1. George S.R., Zastawney R.L., Briones-Urbina R., Cheng R., Nguyen T., Heiber M., Kouvelas A., Chan A.S., O'Dowd B.F. Distinct distributions of μ, δ, and κ opioid receptor mRNA in rat brain. Biochem. Biophys. Res. Commun. 205(2):1994;1438-1444.
2. Gygi S.P., Rochon Y., Franza B.R., Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19(3):1999;1720-1730.
3. Matherne G.P., Byford A.M., Gilrain J.T., Dalkin A.C. Changes in myocardial A1 adenosine receptor and message levels during fetal development and postnatal maturation. Biol. Neonate. 70(4):1996;199-205.
4. Shalon D., Smith S.J., Brown P.O. A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Res. 6:1996;639-645.
5. Shannon, C.E., Weaver, W., 1963. The Mathematical Theory of Communication. University of Illinois Press, Champaign, IL.
6. Uchida Y., Irie K., Tsukahara F., Ohba K., Ogawa A., Fujii E., Muraki T. Endothelin-1, but not endothelin-3, suppresses lipoprotein lipase gene expression in brown adipocytes differentiated in culture. Eur. J. Pharmacol. 291(1):1995;33-41.
7. Velculescu V.E., Zhang L., Vogelstein B., Kinzler K.W. Serial analysis of gene expression. Science. 270:1995;484-487.
8. Wen X., Fuhrman S., Michaels G.S., Carr D.B., Smith S., Barker J.L., Somogyi R. Large-scale temporal gene expression mapping of CNS development. Proc. Natl. Acad. Sci. USA. 95:1998;334-339.