메뉴 건너뛰기




Volumn 3, Issue 6, 2002, Pages 853-858

ATP-binding cassette transporters in macrophages: Promising drug targets for treatment of cardiovascular disease

Author keywords

ABCA1; Atherosclerosis; Filipodia; High density lipoprotein; LXR RXR; Rafts

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ABC A1 TRANSPORTER; ABC TRANSPORTER; ACETYLPODOCARPIC DIMER; CHOLESTEROL; FATTY ACID; HIGH DENSITY LIPOPROTEIN; HORMONE RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; LG 268; LIPID; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; MEMBRANE PROTEIN; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; RETINOID X RECEPTOR; STEROL; UNCLASSIFIED DRUG;

EID: 0036628389     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (11)

References (40)
  • 1
    • 0034953105 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M, Hamon Y, Chimini G: The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res (2001) 42:1007-1017.
    • (2001) J Lipid Res , vol.42 , pp. 1007-1017
    • Dean, M.1    Hamon, Y.2    Chimini, G.3
  • 10
    • 0036120566 scopus 로고    scopus 로고
    • Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages
    • note
    • Aiello RJ, Brees D, Bourassa PA, Royer L, Lindsey S, Coskran T, Haghpassand M, Francone OL: Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages. Arterioscler Thromb Vasc Biol (2002) 22:630-637. Selected inactivation of macrophage ABCA1 is accompanied by an increase in atherosclerotic lesion progression in hypercholesterolemic apoE-deficient and LDLR receptor-deficient mice, without significant effect on plasma HDL.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 630-637
    • Aiello, R.J.1    Brees, D.2    Bourassa, P.A.3    Royer, L.4    Lindsey, S.5    Coskran, T.6    Haghpassand, M.7    Francone, O.L.8
  • 11
    • 18344364090 scopus 로고    scopus 로고
    • Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    • note
    • Van Eck M, Bos IS, Kaminski WE, Orso E, Rothe G, Twisk J, Bottcher A, Van Amersfoort ES, Christiansen-Weber TA, Fung-Leung WP, Van Berkel TJC, Schmitz G: Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci USA (2002) 99:6298-6303. LDL receptor knockout mice that are selectively deficient in leukocyte ABCA1 develop more advanced atherosclerosis lesions, without effect on plasma HDL levels. In addition, the amount of macrophages in liver and spleen and peripheral blood leukocyte counts is increased in animals deficient in leukocyte ABCA1.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6298-6303
    • Van Eck, M.1    Bos, I.S.2    Kaminski, W.E.3    Orso, E.4    Rothe, G.5    Twisk, J.6    Bottcher, A.7    Van Amersfoort, E.S.8    Christiansen-Weber, T.A.9    Fung-Leung, W.P.10    Van Berkel, T.J.C.11    Schmitz, G.12
  • 12
    • 0035202240 scopus 로고    scopus 로고
    • Apoliproprotein AI and HDL(3) inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42
    • note
    • Diederich W, Orso E, Drobnik W, Schmitz G: Apoliproprotein AI and HDL(3) inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42. Atherosclerosis (2001) 159:313-324. Cellular cholesterol homeostasis regulates the formation of membrane extensions via cdc42. The apoA-I-induced inhibition of filipodia formation and chemotaxis of monocyte may be of relevance for recruitment of monocytes into the vessel wall
    • (2001) Atherosclerosis , vol.159 , pp. 313-324
    • Diederich, W.1    Orso, E.2    Drobnik, W.3    Schmitz, G.4
  • 13
    • 0035964745 scopus 로고    scopus 로고
    • ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP
    • note
    • Tsukamoto K, Hirano K, Tsujii K, Ikegami C, Zhongyan Z, Nishida Y, Ohama T, Matsuura F, Yamashita S, Matsuzawa Y: ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP. Biochem Biophys Res Commun (2001) 287:757-65. Expression of ABCA1 in HEK293 cells stimulates the formation of long membrane protrusions, which is inhibited by a dominant negative form of cdc42. Co-immunprecipitation suggests a direct interaction between cdc42 and ABCA1.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 757-765
    • Tsukamoto, K.1    Hirano, K.2    Tsujii, K.3    Ikegami, C.4    Zhongyan, Z.5    Nishida, Y.6    Ohama, T.7    Matsuura, F.8    Yamashita, S.9    Matsuzawa, Y.10
  • 14
    • 0036215273 scopus 로고    scopus 로고
    • Apo AI/ABCA1-dependent and HDL-3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains
    • note
    • Drobnik W, Borsukova H, Bottcher A, Pfeiffer A, Liebisch G, Schutz GJ, Schindler H, Schmitz G: Apo AI/ABCA1-dependent and HDL-3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains. Traffic (2002) 3:268-278. The paper provides a detailed comparison of the lipid and protein composition of two compositionally distinct cholesterol-based lipid microdomains, which are discriminated by their different solubility in Triton X-100 and Lubrol WX. ApoA-I and HDL differentially modify these raft domains in a cell-type specific manner, whereas apoA-I-mediated lipid efflux seems to primarily involve Lubrol rafts.
    • (2002) Traffic , vol.3 , pp. 268-278
    • Drobnik, W.1    Borsukova, H.2    Bottcher, A.3    Pfeiffer, A.4    Liebisch, G.5    Schutz, G.J.6    Schindler, H.7    Schmitz, G.8
  • 15
    • 0034282003 scopus 로고    scopus 로고
    • Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane
    • note
    • Roper K, Corbeil D, Huttner WB: Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane. Nat Cell Biol (2000) 2:582-592. The authors provide the first evidence that distinct cholesterol-based lipid microdomains can be distinguished by their different solubility in Triton X-100 and Lubrol WX. Domains that are soluble in Triton but insoluble in Lubrol were termed Lubrol rafts and found to be associated with membrane protrusions.
    • (2000) Nat Cell Biol , vol.2 , pp. 582-592
    • Roper, K.1    Corbeil, D.2    Huttner, W.B.3
  • 19
    • 0034736108 scopus 로고    scopus 로고
    • Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: Tandem linkage with the minor histocompatibility antigen HA-1 gene
    • Kaminski WE, Piehler A, Schmitz G: Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: Tandem linkage with the minor histocompatibility antigen HA-1 gene. Biochem Biophys Res Commun (2000) 278:782-789.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 782-789
    • Kaminski, W.E.1    Piehler, A.2    Schmitz, G.3
  • 20
    • 0037177846 scopus 로고    scopus 로고
    • Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 promoter. Role of Sp1/3, E-box binding factors, and an oncostatin M-responsive element
    • note
    • Langmann T, Porsch-Ozcurumez M, Heimerl S, Probst M, Moehle C, Taher M, Borsukova H, Kielar D, Kaminski WE, Dittrich-Wengenroth E, Schmitz G: Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 promoter. Role of Sp1/3, E-box binding factors, and an oncostatin M-responsive element. J Biol Chem (2002) 277:14443-14450. Oncostatin M-induced ABCA1 transcription provides a new concept on how members of the interleukin-6 family of cytokines may regulate lipid transport proteins.
    • (2002) J Biol Chem , vol.277 , pp. 14443-14450
    • Langmann, T.1    Porsch-Ozcurumez, M.2    Heimerl, S.3    Probst, M.4    Moehle, C.5    Taher, M.6    Borsukova, H.7    Kielar, D.8    Kaminski, W.E.9    Dittrich-Wengenroth, E.10    Schmitz, G.11
  • 21
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet P, Luo Y, Wang N, Tall AR: Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem (2000) 275:28240-28245.
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 23
    • 0035914330 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    • note
    • Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP, Lund EG: 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem (2001) 276:38378-38387. The paper indicates that 27-hydroxycholesterol but not other proposed LXR ligands, including 20(S)-hydroxycholesterol, 22(R)-hydroxycholesterol and 24(S)-25-epoxycholesterol, are regulators of ABCA1 expression in macrophages.
    • (2001) J Biol Chem , vol.276 , pp. 38378-38387
    • Fu, X.1    Menke, J.G.2    Chen, Y.3    Zhou, G.4    MacNaul, K.L.5    Wright, S.D.6    Sparrow, C.P.7    Lund, E.G.8
  • 31
    • 17744390348 scopus 로고    scopus 로고
    • Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    • note
    • Berge KE, Tian H, Graft GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science (2000) 290:1771-1775. The authors describe six mutations in ABCG8 and one in ABCG5 in nine patients with sitosterolemia. The two genes are expressed at highest levels in liver and intestine and, in mice, cholesterol feeding upregulates expression of both genes.
    • (2000) Science , vol.290 , pp. 1771-1775
    • Berge, K.E.1    Tian, H.2    Graft, G.A.3    Yu, L.4    Grishin, N.V.5    Schultz, J.6    Kwiterovich, P.7    Shan, B.8    Barnes, R.9    Hobbs, H.H.10
  • 33
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of ATP-binding cassette sterol transporters, ABCG5 and ABCG8, by the oxysterol receptors, LXRα and β
    • In press
    • Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs HH, Mangelsdorf DJ: Regulation of ATP-binding cassette sterol transporters, ABCG5 and ABCG8, by the oxysterol receptors, LXRα and β. J Biol Chem (2002): In press.
    • (2002) J Biol Chem
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3    Richardson, J.A.4    Hobbs, H.H.5    Mangelsdorf, D.J.6
  • 36
    • 0035971064 scopus 로고    scopus 로고
    • Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter
    • Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G: Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. J Biol Chem (2001) 276:9955-9960.
    • (2001) J Biol Chem , vol.276 , pp. 9955-9960
    • Chambenoit, O.1    Hamon, Y.2    Marguet, D.3    Rigneault, H.4    Rosseneu, M.5    Chimini, G.6
  • 37
    • 0034693064 scopus 로고    scopus 로고
    • Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
    • Wang N, Silver DL, Costet P, Tall AR: Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. J Biol Chem (2000) 275:33053-33058.
    • (2000) J Biol Chem , vol.275 , pp. 33053-33058
    • Wang, N.1    Silver, D.L.2    Costet, P.3    Tall, A.R.4
  • 39
    • 0035900574 scopus 로고    scopus 로고
    • Characterization of the ATPase cycle of human ABCA1: Implications for its function as a regulator rather than an active transporter
    • note
    • Szakacs G, Langmann T, Ozvegy C, Orso E, Schmitz G, Varadi A, Sarkadi B: Characterization of the ATPase cycle of human ABCA1: Implications for its function as a regulator rather than an active transporter. Biochem Biophys Res Commun (2001) 288:1258-1264. In contrast to ABC transporters which exert bona fide pump function, ABCA1, similar to the ABC regulator proteins CFTR and SUR, shows only marginal intrinsic ATPase activity, Thus, ABCA1 may be a transport regulator rather than an active pump.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 1258-1264
    • Szakacs, G.1    Langmann, T.2    Ozvegy, C.3    Orso, E.4    Schmitz, G.5    Varadi, A.6    Sarkadi, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.