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Van Eck M, Bos IS, Kaminski WE, Orso E, Rothe G, Twisk J, Bottcher A, Van Amersfoort ES, Christiansen-Weber TA, Fung-Leung WP, Van Berkel TJC, Schmitz G: Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci USA (2002) 99:6298-6303. LDL receptor knockout mice that are selectively deficient in leukocyte ABCA1 develop more advanced atherosclerosis lesions, without effect on plasma HDL levels. In addition, the amount of macrophages in liver and spleen and peripheral blood leukocyte counts is increased in animals deficient in leukocyte ABCA1.
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Diederich W, Orso E, Drobnik W, Schmitz G: Apoliproprotein AI and HDL(3) inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42. Atherosclerosis (2001) 159:313-324. Cellular cholesterol homeostasis regulates the formation of membrane extensions via cdc42. The apoA-I-induced inhibition of filipodia formation and chemotaxis of monocyte may be of relevance for recruitment of monocytes into the vessel wall
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Tsukamoto K, Hirano K, Tsujii K, Ikegami C, Zhongyan Z, Nishida Y, Ohama T, Matsuura F, Yamashita S, Matsuzawa Y: ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP. Biochem Biophys Res Commun (2001) 287:757-65. Expression of ABCA1 in HEK293 cells stimulates the formation of long membrane protrusions, which is inhibited by a dominant negative form of cdc42. Co-immunprecipitation suggests a direct interaction between cdc42 and ABCA1.
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Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)
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Langmann T, Porsch-Ozcurumez M, Heimerl S, Probst M, Moehle C, Taher M, Borsukova H, Kielar D, Kaminski WE, Dittrich-Wengenroth E, Schmitz G: Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 promoter. Role of Sp1/3, E-box binding factors, and an oncostatin M-responsive element. J Biol Chem (2002) 277:14443-14450. Oncostatin M-induced ABCA1 transcription provides a new concept on how members of the interleukin-6 family of cytokines may regulate lipid transport proteins.
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Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP, Lund EG: 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem (2001) 276:38378-38387. The paper indicates that 27-hydroxycholesterol but not other proposed LXR ligands, including 20(S)-hydroxycholesterol, 22(R)-hydroxycholesterol and 24(S)-25-epoxycholesterol, are regulators of ABCA1 expression in macrophages.
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PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
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31
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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
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note
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Berge KE, Tian H, Graft GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science (2000) 290:1771-1775. The authors describe six mutations in ABCG8 and one in ABCG5 in nine patients with sitosterolemia. The two genes are expressed at highest levels in liver and intestine and, in mice, cholesterol feeding upregulates expression of both genes.
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note
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Lee MH, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, Kojima H, Allikmets R, Sakuma N, Pegoraro R, Srivastava AK, Salen G, Dean M, Patel SB: Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet (2001) 27:79-83. The paper reports that a ABCG5 is mutant in nine unrelated sitosterolemia patients.
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Regulation of ATP-binding cassette sterol transporters, ABCG5 and ABCG8, by the oxysterol receptors, LXRα and β
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In press
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36
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0035971064
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Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter
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Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G: Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. J Biol Chem (2001) 276:9955-9960.
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37
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Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
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Wang N, Silver DL, Costet P, Tall AR: Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. J Biol Chem (2000) 275:33053-33058.
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38
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Neufeld EB, Remaley AT, Demosky SJ, Stonik JA, Cooney AM, Comly M, Dwyer NK, Zhang M, Blanchette-Mackie J, Santamarina-Fojo S, Brewer Jr HB: Cellular localization and trafficking of the human ABCA1 transporter. J Biol Chem (2001) 276:27584-27590.
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Characterization of the ATPase cycle of human ABCA1: Implications for its function as a regulator rather than an active transporter
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note
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Szakacs G, Langmann T, Ozvegy C, Orso E, Schmitz G, Varadi A, Sarkadi B: Characterization of the ATPase cycle of human ABCA1: Implications for its function as a regulator rather than an active transporter. Biochem Biophys Res Commun (2001) 288:1258-1264. In contrast to ABC transporters which exert bona fide pump function, ABCA1, similar to the ABC regulator proteins CFTR and SUR, shows only marginal intrinsic ATPase activity, Thus, ABCA1 may be a transport regulator rather than an active pump.
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Szakacs, G.1
Langmann, T.2
Ozvegy, C.3
Orso, E.4
Schmitz, G.5
Varadi, A.6
Sarkadi, B.7
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40
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Vesicular trafficking of ABCA1 is mediated by a direct interaction with β2 syntrophin
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Buchler C, Bottcher A, Maa Bared S, Ritter M, Schmitz G. Vesicular trafficking of ABCA1 is mediated by a direct interaction with β2 syntrophin. Biochem Biophys Res Commun (2002) 293:759-765.
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Buchler, C.1
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Schmitz, G.5
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