Apolipoprotein AI and HDL3 inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42

Atherosclerosis

Volumn 159, Issue 2, 2001, Pages 313-324

  Diederich, W ^a   Orso E ^a   Drobnik, W ^a   Schmitz, G ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Apo AI; Cholesterol; HDL3; Monocytes; Spreading

Indexed keywords

APOLIPOPROTEIN A1; BETA1 INTEGRIN; CD16 ANTIGEN; CHOLESTEROL; COLONY STIMULATING FACTOR 1; CYCLODEXTRIN; HIGH DENSITY LIPOPROTEIN; INTEGRIN; PROTEIN CDC42; SCAVENGER RECEPTOR;

ADULT; AGED; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CASE REPORT; CELL LEVEL; CELL SPREADING; CHEMOTAXIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

APOLIPOPROTEIN A-I; BLOTTING, WESTERN; CDC42 GTP-BINDING PROTEIN; CELLS, CULTURED; CHOLESTEROL, HDL; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MONOCYTES; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TANGIER DISEASE;

EID: 0035202240     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00518-4     Document Type: Article

References (63)

1. Study of U.S. medical school applicants, 1975-76
2. Cell cholesterol efflux: Integration of old and new observations provides new insights
3. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
4. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
5. Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice
6. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
7. Atheroprotective mechanisms of HDL
8. High density associated enzymes: Their role in vascular biology
9. Apolipoprotein A-I decreases neutrophil degranulation and superoxide production
10. Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells
11. Inhibition of VCAM-1 expression in endothelial cells by reconstituted high density lipoproteins
12. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules
13. Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia. Differential effects of plasma lipoproteins on monocyte 30 function
14. High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL
15. Endothelial adhesion molecules in health and disease
16. Reconstituted high density lipoprotein modulates adherence of polymorphonuclear leukocytes to human endothelial cells
17. Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42
18. Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1
19. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
20. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
21. Activation of Rac and Cdc42 by integrins mediates cell spreading
22. A role for Cdc42 in macrophage chemotaxis
23. Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes
24. Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis
25. Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E
26. Role of macrophage colony-stimulating factor in atherosclerosis: Studies of osteopetrotic mice
27. Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia
28. On the pathogenesis of atherosclerosis enzymatic transformation of human low density lipoprotein to an atherogenic moiety
29. Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation
30. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
31. Blood monocyte chemotaxis
32. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
33. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
34. Enhanced upregulation of the Fc gamma receptor lila (CD16a) during in vitro differentiation of ApoE4/4 monocytes
35. Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia
36. Detection of intracellular cytokines by flow cytometry
37. Regulation of p21rac activation in human neutrophils
38. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
39. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
40. + monocytes and induces foam cell formation mediated only in part by the class B scavanger receptors
41. The Rho GTPases in macrophage motility and chemotaxis
42. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes. A regulatory role for plasma LDL
43. Rho GTPases control polarity, protrusion, and adhesion during cell movement
44. Signal transduction by cell adhesion receptors
45. Identification of the haemoglobin scavenger receptor
46. Enhanced metabolism of LDL aggregates mediated by specific human monocyte IgG Fc receptors
47. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antunflammatory stimuli
48. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163)
49. Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface
50. Plasma membrane caveolae mediate the efflux of cellular free cholesterol
51. Membrane microdomains and caveolae
52. Decreased expression of a member of the rho GTPase family, Cdc42Hs, in cells from tangier disease-the small G protein may play a role in cholesterol efflux
53. Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42
54. Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins
55. A role for Cdc42 in macrophage chemotaxis
56. Identification of an actin cytoskeletal complex that includes IQGAP and the Cdc42 GTPase
57. Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus
58. Characterization of the association of the actin-binding protein, IQGAP, and activated Cdc42 with Golgi membranes
59. Cell-permeable ceramides prevent the activation of phospholipase D by ADP-ribosylation factor and RhoA
60. Resolved phospholipase D activity is modulated by cytosolic factors other than Arf
61. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D
62. Integrinmediated signals regulated by members of the rho family of GTPases
63. The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast