-
1
-
-
0034077507
-
Sequencing the entire genomes of free-living organims: The foundation of pharmacology in the new millennium
-
Broder S, Venter JC: Sequencing the entire genomes of free-living organims: The foundation of pharmacology in the new millennium. Ann Rev Pharmacol Toxicol (2000) 40:97-132.
-
(2000)
Ann. Rev. Pharmacol. Toxicol
, vol.40
, pp. 97-132
-
-
Broder, S.1
Venter, J.C.2
-
3
-
-
0033998895
-
DNA arrays: Technology, options and toxicological applications
-
Rockett JC, Dix DJ: DNA arrays: Technology, options and toxicological applications. Xenobiotica (2000) 30:155-177.
-
(2000)
Xenobiotica
, vol.30
, pp. 155-177
-
-
Rockett, J.C.1
Dix, D.J.2
-
5
-
-
0032919458
-
Options available - From start to finish - For obtaining expression data by microarray
-
Bowtell DDL: Options available - from start to finish - for obtaining expression data by microarray. Nat Genet (1999) 21:25-32.
-
(1999)
Nat. Genet
, vol.21
, pp. 25-32
-
-
Bowtell, D.D.L.1
-
6
-
-
0034653961
-
Use of cDNA microarrays to probe and understand the toxicological consequences of altered gene expression
-
Pennie WD: Use of cDNA microarrays to probe and understand the toxicological consequences of altered gene expression. Toxicol Lett (2000) 112-113:473-477.
-
(2000)
Toxicol. Lett
, vol.112-113
, pp. 473-477
-
-
Pennie, W.D.1
-
7
-
-
0033015986
-
Identification of the genes responsive to etoposide-induced apoptosis: Application of DNA chip technology
-
Wang Y, Rea T, Bian J, Gray S, Sun Y: Identification of the genes responsive to etoposide-induced apoptosis: Application of DNA chip technology. FEBS Lett (1999) 445:269-273.
-
(1999)
FEBS Lett
, vol.445
, pp. 269-273
-
-
Wang, Y.1
Rea, T.2
Bian, J.3
Gray, S.4
Sun, Y.5
-
8
-
-
0033649402
-
Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression
-
Holden PR, James NH, Brooks AN, Roberts RA, Kimber I, Pennie WD: Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression. J Biochem Mol Toxicol (2000) 14:283-290.
-
(2000)
J. Biochem. Mol. Toxicol
, vol.14
, pp. 283-290
-
-
Holden, P.R.1
James, N.H.2
Brooks, A.N.3
Roberts, R.A.4
Kimber, I.5
Pennie, W.D.6
-
9
-
-
0034825987
-
The use of genomics technology to investigate gene expression changes in cultured human liver cells
-
Harries HM, Fletcher ST, Duggan CM, Baker VA: The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol Vitro (2001) 15:399-405.
-
(2001)
Toxicol. Vitro
, vol.15
, pp. 399-405
-
-
Harries, H.M.1
Fletcher, S.T.2
Duggan, C.M.3
Baker, V.A.4
-
10
-
-
0034813628
-
Expression profiling of acetaminophen liver toxicity in mice using microarray technology
-
Reilly TP, Bourdi M, Brady JN, Pise-Masison CA, Radonovich MF, George JW, Pohl LR: Expression profiling of acetaminophen liver toxicity in mice using microarray technology. Biochem Biophys Res Commun (2001) 282:321-328.
-
(2001)
Biochem. Biophys. Res. Commun
, vol.282
, pp. 321-328
-
-
Reilly, T.P.1
Bourdi, M.2
Brady, J.N.3
Pise-Masison, C.A.4
Radonovich, M.F.5
George, J.W.6
Pohl, L.R.7
-
11
-
-
0033867101
-
Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and γ-glutamylcysteine synthetase
-
Kitteringham NR, Powell H, Clement YN, Dodd CC, Tettey JN, Pirmohamed M, Smith DA, McLellan LI, Park BK: Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and γ-glutamylcysteine synthetase. Hepatology (2000) 32:321-333.
-
(2000)
Hepatology
, vol.32
, pp. 321-333
-
-
Kitteringham, N.R.1
Powell, H.2
Clement, Y.N.3
Dodd, C.C.4
Tettey, J.N.5
Pirmohamed, M.6
Smith, D.A.7
McLellan, L.I.8
Park, B.K.9
-
12
-
-
0025642605
-
Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices
-
Wolfgang GHI, Donarski WJ, Petry TW: Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices. Toxicol Appl Pharmacol (1990) 106:63-70.
-
(1990)
Toxicol. Appl. Pharmacol
, vol.106
, pp. 63-70
-
-
Wolfgang, G.H.I.1
Donarski, W.J.2
Petry, T.W.3
-
13
-
-
0023637761
-
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity
-
Bannister R, Davis D, Zacharewski T, Tizard I, Safe S: Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity. Toxicology (1987) 46:29-42.
-
(1987)
Toxicology
, vol.46
, pp. 29-42
-
-
Bannister, R.1
Davis, D.2
Zacharewski, T.3
Tizard, I.4
Safe, S.5
-
14
-
-
0024788818
-
The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells
-
Steinberg P, Schramm H, Schladt L, Robertson LW, Thomas H, Oesch F: The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells. Biochem J (1989) 264:737-744.
-
(1989)
Biochem. J
, vol.264
, pp. 737-744
-
-
Steinberg, P.1
Schramm, H.2
Schladt, L.3
Robertson, L.W.4
Thomas, H.5
Oesch, F.6
-
15
-
-
0030601796
-
New proteins in the rat CYP2B subfamily: Presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA
-
Desrochers M, Christou M, Jefcoate C, Belzil A, Anderson A: New proteins in the rat CYP2B subfamily: Presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA. Biochem Pharmacol (1996) 52:1311-1319.
-
(1996)
Biochem. Pharmacol
, vol.52
, pp. 1311-1319
-
-
Desrochers, M.1
Christou, M.2
Jefcoate, C.3
Belzil, A.4
Anderson, A.5
-
16
-
-
0030895678
-
Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s)
-
Luukkanen L, Elovaara E, Lautala P, Taskinen J, Vainio H: Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s). Pharmacol Toxicol (1997) 80:152-158.
-
(1997)
Pharmacol. Toxicol
, vol.80
, pp. 152-158
-
-
Luukkanen, L.1
Elovaara, E.2
Lautala, P.3
Taskinen, J.4
Vainio, H.5
-
17
-
-
0028276386
-
Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2
-
Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF: Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J Biol Chem (1994) 269:13092-13099.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 13092-13099
-
-
Sutter, T.R.1
Tang, Y.M.2
Hayes, C.L.3
Wo, Y.Y.4
Jabs, E.W.5
Li, X.6
Yin, H.7
Cody, C.W.8
Greenlee, W.F.9
-
18
-
-
0028328463
-
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells
-
Christou M, Saves U, Spink DC, Gierthy JF, Jefcoate CR: Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells. Carcinogenesis (1994) 15:725-732.
-
(1994)
Carcinogenesis
, vol.15
, pp. 725-732
-
-
Christou, M.1
Savas, U.2
Spink, D.C.3
Gierthy, J.F.4
Jefcoate, C.R.5
-
19
-
-
0034651240
-
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by cournarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver
-
Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of aflatoxin B1 hepatocarcinogenesis by cournarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer Res (2000) 60:957-969.
-
(2000)
Cancer Res
, vol.60
, pp. 957-969
-
-
Kelly, V.P.1
Ellis, E.M.2
Manson, M.M.3
Chanas, S.A.4
Moffat, G.J.5
McLeod, R.6
Judah, D.J.7
Neal, G.E.8
Hayes, J.D.9
-
20
-
-
0035228228
-
Development of a 950-gene DNA array for examining gene expression patterns in mouse testis
-
Rockett JC, Luft JC, Garges; JB, Krawetz SA, Hughes MR, Kim KH, Oudes A.J, Dix DJ: Development of a 950-gene DNA array for examining gene expression patterns in mouse testis. Genome Biol (2001) 2:0014.1-0014.9.
-
(2001)
Genome Biol
, vol.2
-
-
Rockett, J.C.1
Luft, J.C.2
Garges, J.B.3
Krawetz, S.A.4
Hughes, M.R.5
Kim, K.H.6
Oudes, A.J.7
Dix, D.J.8
-
21
-
-
0346942394
-
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
-
Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T: Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics (2001) 5:161-170.
-
(2001)
Physiol. Genomics
, vol.5
, pp. 161-170
-
-
Gerhold, D.1
Lu, M.2
Xu, J.3
Austin, C.4
Caskey, C.T.5
Rushmore, T.6
-
22
-
-
0033053403
-
Revolution through genomics in investigative and discovery toxicology
-
Rodi CP, Bunch RT, Curtiss SW, Kier LD, Cabonce MA, Davila JC, Mitchell MD, Alden CL, Morris DL: Revolution through genomics in investigative and discovery toxicology. Toxicol Pathol (1999) 27:107-110.
-
(1999)
Toxicol. Pathol
, vol.27
, pp. 107-110
-
-
Rodi, C.P.1
Bunch, R.T.2
Curtiss, S.W.3
Kier, L.D.4
Cabonce, M.A.5
Davila, J.C.6
Mitchell, M.D.7
Alden, C.L.8
Morris, D.L.9
-
23
-
-
0033573938
-
Global response of Saccharomyces cerevisiae to an alkylating agent
-
Jelinsky SA, Samson LD: Global response of Saccharomyces cerevisiae to an alkylating agent. Proc Natl Acad Sci USA (1999) 96:1486-1491.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1486-1491
-
-
Jelinsky, S.A.1
Samson, L.D.2
-
24
-
-
0035147169
-
Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene
-
Bartosiewicz M, Penn S, Buckpitt A: Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ Health Perspect (2001) 109:71-74.
-
(2001)
Environ. Health Perspect
, vol.109
, pp. 71-74
-
-
Bartosiewicz, M.1
Penn, S.2
Buckpitt, A.3
-
25
-
-
0034176929
-
Development of a toxicological gene array and quantitative assessment of this technology
-
Bartosiewicz M, Trounstine M, Barker D, Johnston R, Buckpitt A: Development of a toxicological gene array and quantitative assessment of this technology. Arch Biochem Biophys (2000) 376:66-73.
-
(2000)
Arch. Biochem. Biophys
, vol.376
, pp. 66-73
-
-
Bartosiewicz, M.1
Trounstine, M.2
Barker, D.3
Johnston, R.4
Buckpitt, A.5
-
27
-
-
0034616930
-
Functional discovery via a compendium of expression profiles
-
Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, Kidd MJ, King AM, Meyer MR, Slade D, Lum PY, Stepaniants SB, Shoemaker DD, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend SH: Functional discovery via a compendium of expression profiles. Cell (2000) 102:109-126.
-
(2000)
Cell
, vol.102
, pp. 109-126
-
-
Hughes, T.R.1
Marton, M.J.2
Jones, A.R.3
Roberts, C.J.4
Stoughton, R.5
Armour, C.D.6
Bennett, H.A.7
Coffey, E.8
Dai, H.9
He, Y.D.10
Kidd, M.J.11
King, A.M.12
Meyer, M.R.13
Slade, D.14
Lum, P.Y.15
Stepaniants, S.B.16
Shoemaker, D.D.17
Gachotte, D.18
Chakraburtty, K.19
Simon, J.20
Bard, M.21
Friend, S.H.22
more..
-
28
-
-
0035038751
-
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays
-
Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR, De La lglesia FA: RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology (2001) 33:1239-1258.
-
(2001)
Hepatology
, vol.33
, pp. 1239-1258
-
-
Bulera, S.J.1
Eddy, S.M.2
Ferguson, E.3
Jatkoe, T.A.4
Reindel, J.F.5
Bleavins, M.R.6
De La lglesia, F.A.7
-
29
-
-
0035977845
-
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity
-
Waring JF, Ciurlionis R, Jolly RA, Heindel M, Ulrich RG: Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol Lett (2001) 120:359-368.
-
(2001)
Toxicol. Lett
, vol.120
, pp. 359-368
-
-
Waring, J.F.1
Ciurlionis, R.2
Jolly, R.A.3
Heindel, M.4
Ulrich, R.G.5
-
30
-
-
17944366528
-
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles
-
Waring JF, Jolly RA, Ciudionis R, Lum PY, Praestgaard JT, Morfitt DC, Buratto B, Roberts C, Schadt E, Ulrich RG: Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicol Appl Pharmacol (2001) 175:28-42.
-
(2001)
Toxicol. Appl. Pharmacol
, vol.175
, pp. 28-42
-
-
Waring, J.F.1
Jolly, R.A.2
Ciurlionis, R.3
Lum, P.Y.4
Praestgaard, J.T.5
Morfitt, D.C.6
Buratto, B.7
Roberts, C.8
Schadt, E.9
Ulrich, R.G.10
-
31
-
-
0034436356
-
Discovering patterns in microarray data
-
Burke HB: Discovering patterns in microarray data. Mol Diagnostics (2000) 5:349-357.
-
(2000)
Mol. Diagnostics
, vol.5
, pp. 349-357
-
-
Burke, H.B.1
-
32
-
-
0021945643
-
Studies on the mechanism of action of halogenated aromatic hydrocarbons
-
Poland A, Knutson J, Glover E: Studies on the mechanism of action of halogenated aromatic hydrocarbons. Clin Physiol Biochem (1985) 3:147-154.
-
(1985)
Clin. Physiol. Biochem
, vol.3
, pp. 147-154
-
-
Poland, A.1
Knutson, J.2
Glover, E.3
-
33
-
-
0021893084
-
PCBs: Structure-function relationships and mechanism of action
-
Safe S, Bandiera S, Sawyer T, Robertson L, Safe L, Parkinson A, Thomas PE, Ryan DE, Reik LM, Levin W: PCBs: Structure-function relationships and mechanism of action. Environ Health Perspect (1985) 60:47-56.
-
(1985)
Environ. Health Perspect
, vol.60
, pp. 47-56
-
-
Safe, S.1
Bandiera, S.2
Sawyer, T.3
Robertson, L.4
Safe, L.5
Parkinson, A.6
Thomas, P.E.7
Ryan, D.E.8
Reik, L.M.9
Levin, W.10
-
34
-
-
17944383948
-
Identifying toxic mechanisms using dna microarrays: Evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor
-
in press
-
Waring JF, Gum R, Morfitt D, Jolly RA, Ciurlionis R, Heindel M, Gallenberg L, Buratto B, Ulrich RG: Identifying toxic mechanisms using dna microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor. Toxicology (2002) in press
-
(2002)
Toxicology
-
-
Waring, J.F.1
Gum, R.2
Morfitt, D.3
Jolly, R.A.4
Ciurlionis, R.5
Heindel, M.6
Gallenberg, L.7
Buratto, B.8
Ulrich, R.G.9
-
35
-
-
0033678984
-
Gene expression microarray data analysis for toxicology profiling
-
Cunningham MJ, Liang S, Fuhrman S, Sielhamer JJ, Somogyi R: Gene expression microarray data analysis for toxicology profiling. Ann NY Acad Sci (2000) 919:52-67.
-
(2000)
Ann. NY Acad. Sci
, vol.919
, pp. 52-67
-
-
Cunningham, M.J.1
Liang, S.2
Fuhrman, S.3
Sielhamer, J.J.4
Somogyi, R.5
-
36
-
-
0034518116
-
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells
-
Burczynski ME, McMillian M, Ciervo J, Li L, Parker JB, Dunn RT, Hicken S, Farr S, Johnson MD: Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicol Sci (2000) 58:399-415.
-
(2000)
Toxicol. Sci
, vol.58
, pp. 399-415
-
-
Burczynski, M.E.1
McMillian, M.2
Ciervo, J.3
Li, L.4
Parker, J.B.5
Dunn, R.T.6
Hicken, S.7
Farr, S.8
Johnson, M.D.9
-
37
-
-
0035213686
-
Identification of toxicologically predictive gene sets using cDNA microarrays
-
Thomas RS, Rank DR, Penn SG, Zastrow GM, Hayes KR, Pande K, Glover E, Silander T, Craven MIN, Reddy JK, Jovanovich SB, Bradfield CA: Identification of toxicologically predictive gene sets using cDNA microarrays. Mol Pharmacol (2001) 60:1189-1194.
-
(2001)
Mol. Pharmacol
, vol.60
, pp. 1189-1194
-
-
Thomas, R.S.1
Rank, D.R.2
Penn, S.G.3
Zastrow, G.M.4
Hayes, K.R.5
Pande, K.6
Glover, E.7
Silander, T.8
Craven, M.I.N.9
Reddy, J.K.10
Jovanovich, S.B.11
Bradfield, C.A.12
-
38
-
-
0033867226
-
Detection of cytochrome P450 and other drug-metabolizing enzyme mRNAs in peripheral blood mononuclear cells using DNA arrays
-
Nguyen LT, Ramanathan M, Weinstock-Guttman B, Dole K, Miller C, Planter M, Patrick K, Brownscheidle C, Jacobs LD: Detection of cytochrome P450 and other drug-metabolizing enzyme mRNAs in peripheral blood mononuclear cells using DNA arrays. Drug Metab Dispos (2000) 28:987-993.
-
(2000)
Drug Metab. Dispos
, vol.28
, pp. 987-993
-
-
Nguyen, L.T.1
Ramanathan, M.2
Weinstock-Guttman, B.3
Dole, K.4
Miller, C.5
Planter, M.6
Patrick, K.7
Brownscheidle, C.8
Jacobs, L.D.9
-
39
-
-
0034040714
-
Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gone expression in human blood cells
-
Krovat BC, Tracy JH, Omiecinski CJ: Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gone expression in human blood cells. Toxicol Sci (2000) 55:352-360.
-
(2000)
Toxicol. Sci
, vol.55
, pp. 352-360
-
-
Krovat, B.C.1
Tracy, J.H.2
Omiecinski, C.J.3
-
40
-
-
0037122982
-
Toxicogenomics gains impetus
-
Gershon D: Toxicogenomics gains impetus. Nature (2002) 415:4-5.
-
(2002)
Nature
, vol.415
, pp. 4-5
-
-
Gershon, D.1
-
41
-
-
0036153531
-
The National Center for Toxicogenomics: Using new technologies to inform mechanistic toxicology
-
Tennant RW: The National Center for Toxicogenomics: Using new technologies to inform mechanistic toxicology. Environ Health Perspect (2002) 110:A8-Al0.
-
(2002)
Environ. Health Perspect
, vol.110
-
-
Tennant, R.W.1
-
42
-
-
0035092715
-
Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology
-
Fielden MR, Zacharewskii TR: Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicol Sci (2001) 60:6-10.
-
(2001)
Toxicol. Sci
, vol.60
, pp. 6-10
-
-
Fielden, M.R.1
Zacharewskii, T.R.2
-
43
-
-
0036043671
-
Toxicogenomics and drug discovery: Will new technologies help us produce better drugs?
-
Ulrich RG, Friend SH: Toxicogenomics and drug discovery: Will new technologies help us produce better drugs? Nat Rev Drug Discov (2002) 1:84-88.
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, pp. 84-88
-
-
Ulrich, R.G.1
Friend, S.H.2
|