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Volumn 4, Issue 3, 2002, Pages 229-235

The promise of toxicogenomics

Author keywords

Gene expression; Gene expression profiling; Mechanistic toxicology; Microarray; Predictive toxicology; Toxicogenomics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; ALCOHOL; AMIODARONE; AROCLOR 1254; ARSENIC; BENZO[A]PYRENE; BETA NAPHTHOFLAVONE; CADMIUM CHLORIDE; CARBAMAZEPINE; CARBON TETRACHLORIDE; CYANOGINOSIN; CYPROTERONE ACETATE; DIETHYLNITROSAMINE; DIQUAT; DNA; ETOPOSIDE; INDOMETACIN; LIPOPOLYSACCHARIDE; MESYLIC ACID METHYL ESTER; METHAPYRILENE; METHOTREXATE; MONOCROTALINE; PARACETAMOL; PEROXISOME PROLIFERATOR; PHENOBARBITAL; POLYCYCLIC AROMATIC HYDROCARBON; THIOACETAMIDE; TRICHLOROETHYLENE;

EID: 0036624289     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (44)

References (43)
  • 1
    • 0034077507 scopus 로고    scopus 로고
    • Sequencing the entire genomes of free-living organims: The foundation of pharmacology in the new millennium
    • Broder S, Venter JC: Sequencing the entire genomes of free-living organims: The foundation of pharmacology in the new millennium. Ann Rev Pharmacol Toxicol (2000) 40:97-132.
    • (2000) Ann. Rev. Pharmacol. Toxicol , vol.40 , pp. 97-132
    • Broder, S.1    Venter, J.C.2
  • 3
    • 0033998895 scopus 로고    scopus 로고
    • DNA arrays: Technology, options and toxicological applications
    • Rockett JC, Dix DJ: DNA arrays: Technology, options and toxicological applications. Xenobiotica (2000) 30:155-177.
    • (2000) Xenobiotica , vol.30 , pp. 155-177
    • Rockett, J.C.1    Dix, D.J.2
  • 5
    • 0032919458 scopus 로고    scopus 로고
    • Options available - From start to finish - For obtaining expression data by microarray
    • Bowtell DDL: Options available - from start to finish - for obtaining expression data by microarray. Nat Genet (1999) 21:25-32.
    • (1999) Nat. Genet , vol.21 , pp. 25-32
    • Bowtell, D.D.L.1
  • 6
    • 0034653961 scopus 로고    scopus 로고
    • Use of cDNA microarrays to probe and understand the toxicological consequences of altered gene expression
    • Pennie WD: Use of cDNA microarrays to probe and understand the toxicological consequences of altered gene expression. Toxicol Lett (2000) 112-113:473-477.
    • (2000) Toxicol. Lett , vol.112-113 , pp. 473-477
    • Pennie, W.D.1
  • 7
    • 0033015986 scopus 로고    scopus 로고
    • Identification of the genes responsive to etoposide-induced apoptosis: Application of DNA chip technology
    • Wang Y, Rea T, Bian J, Gray S, Sun Y: Identification of the genes responsive to etoposide-induced apoptosis: Application of DNA chip technology. FEBS Lett (1999) 445:269-273.
    • (1999) FEBS Lett , vol.445 , pp. 269-273
    • Wang, Y.1    Rea, T.2    Bian, J.3    Gray, S.4    Sun, Y.5
  • 8
    • 0033649402 scopus 로고    scopus 로고
    • Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression
    • Holden PR, James NH, Brooks AN, Roberts RA, Kimber I, Pennie WD: Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression. J Biochem Mol Toxicol (2000) 14:283-290.
    • (2000) J. Biochem. Mol. Toxicol , vol.14 , pp. 283-290
    • Holden, P.R.1    James, N.H.2    Brooks, A.N.3    Roberts, R.A.4    Kimber, I.5    Pennie, W.D.6
  • 9
    • 0034825987 scopus 로고    scopus 로고
    • The use of genomics technology to investigate gene expression changes in cultured human liver cells
    • Harries HM, Fletcher ST, Duggan CM, Baker VA: The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol Vitro (2001) 15:399-405.
    • (2001) Toxicol. Vitro , vol.15 , pp. 399-405
    • Harries, H.M.1    Fletcher, S.T.2    Duggan, C.M.3    Baker, V.A.4
  • 12
    • 0025642605 scopus 로고
    • Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices
    • Wolfgang GHI, Donarski WJ, Petry TW: Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices. Toxicol Appl Pharmacol (1990) 106:63-70.
    • (1990) Toxicol. Appl. Pharmacol , vol.106 , pp. 63-70
    • Wolfgang, G.H.I.1    Donarski, W.J.2    Petry, T.W.3
  • 13
    • 0023637761 scopus 로고
    • Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity
    • Bannister R, Davis D, Zacharewski T, Tizard I, Safe S: Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity. Toxicology (1987) 46:29-42.
    • (1987) Toxicology , vol.46 , pp. 29-42
    • Bannister, R.1    Davis, D.2    Zacharewski, T.3    Tizard, I.4    Safe, S.5
  • 14
    • 0024788818 scopus 로고
    • The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells
    • Steinberg P, Schramm H, Schladt L, Robertson LW, Thomas H, Oesch F: The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells. Biochem J (1989) 264:737-744.
    • (1989) Biochem. J , vol.264 , pp. 737-744
    • Steinberg, P.1    Schramm, H.2    Schladt, L.3    Robertson, L.W.4    Thomas, H.5    Oesch, F.6
  • 15
    • 0030601796 scopus 로고    scopus 로고
    • New proteins in the rat CYP2B subfamily: Presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA
    • Desrochers M, Christou M, Jefcoate C, Belzil A, Anderson A: New proteins in the rat CYP2B subfamily: Presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA. Biochem Pharmacol (1996) 52:1311-1319.
    • (1996) Biochem. Pharmacol , vol.52 , pp. 1311-1319
    • Desrochers, M.1    Christou, M.2    Jefcoate, C.3    Belzil, A.4    Anderson, A.5
  • 16
    • 0030895678 scopus 로고    scopus 로고
    • Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s)
    • Luukkanen L, Elovaara E, Lautala P, Taskinen J, Vainio H: Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s). Pharmacol Toxicol (1997) 80:152-158.
    • (1997) Pharmacol. Toxicol , vol.80 , pp. 152-158
    • Luukkanen, L.1    Elovaara, E.2    Lautala, P.3    Taskinen, J.4    Vainio, H.5
  • 17
    • 0028276386 scopus 로고
    • Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2
    • Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF: Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J Biol Chem (1994) 269:13092-13099.
    • (1994) J. Biol. Chem , vol.269 , pp. 13092-13099
    • Sutter, T.R.1    Tang, Y.M.2    Hayes, C.L.3    Wo, Y.Y.4    Jabs, E.W.5    Li, X.6    Yin, H.7    Cody, C.W.8    Greenlee, W.F.9
  • 18
    • 0028328463 scopus 로고
    • Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells
    • Christou M, Saves U, Spink DC, Gierthy JF, Jefcoate CR: Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells. Carcinogenesis (1994) 15:725-732.
    • (1994) Carcinogenesis , vol.15 , pp. 725-732
    • Christou, M.1    Savas, U.2    Spink, D.C.3    Gierthy, J.F.4    Jefcoate, C.R.5
  • 19
    • 0034651240 scopus 로고    scopus 로고
    • Chemoprevention of aflatoxin B1 hepatocarcinogenesis by cournarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver
    • Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of aflatoxin B1 hepatocarcinogenesis by cournarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. Cancer Res (2000) 60:957-969.
    • (2000) Cancer Res , vol.60 , pp. 957-969
    • Kelly, V.P.1    Ellis, E.M.2    Manson, M.M.3    Chanas, S.A.4    Moffat, G.J.5    McLeod, R.6    Judah, D.J.7    Neal, G.E.8    Hayes, J.D.9
  • 21
    • 0346942394 scopus 로고    scopus 로고
    • Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
    • Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T: Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol Genomics (2001) 5:161-170.
    • (2001) Physiol. Genomics , vol.5 , pp. 161-170
    • Gerhold, D.1    Lu, M.2    Xu, J.3    Austin, C.4    Caskey, C.T.5    Rushmore, T.6
  • 23
    • 0033573938 scopus 로고    scopus 로고
    • Global response of Saccharomyces cerevisiae to an alkylating agent
    • Jelinsky SA, Samson LD: Global response of Saccharomyces cerevisiae to an alkylating agent. Proc Natl Acad Sci USA (1999) 96:1486-1491.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1486-1491
    • Jelinsky, S.A.1    Samson, L.D.2
  • 24
    • 0035147169 scopus 로고    scopus 로고
    • Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene
    • Bartosiewicz M, Penn S, Buckpitt A: Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ Health Perspect (2001) 109:71-74.
    • (2001) Environ. Health Perspect , vol.109 , pp. 71-74
    • Bartosiewicz, M.1    Penn, S.2    Buckpitt, A.3
  • 29
    • 0035977845 scopus 로고    scopus 로고
    • Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity
    • Waring JF, Ciurlionis R, Jolly RA, Heindel M, Ulrich RG: Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol Lett (2001) 120:359-368.
    • (2001) Toxicol. Lett , vol.120 , pp. 359-368
    • Waring, J.F.1    Ciurlionis, R.2    Jolly, R.A.3    Heindel, M.4    Ulrich, R.G.5
  • 31
    • 0034436356 scopus 로고    scopus 로고
    • Discovering patterns in microarray data
    • Burke HB: Discovering patterns in microarray data. Mol Diagnostics (2000) 5:349-357.
    • (2000) Mol. Diagnostics , vol.5 , pp. 349-357
    • Burke, H.B.1
  • 32
    • 0021945643 scopus 로고
    • Studies on the mechanism of action of halogenated aromatic hydrocarbons
    • Poland A, Knutson J, Glover E: Studies on the mechanism of action of halogenated aromatic hydrocarbons. Clin Physiol Biochem (1985) 3:147-154.
    • (1985) Clin. Physiol. Biochem , vol.3 , pp. 147-154
    • Poland, A.1    Knutson, J.2    Glover, E.3
  • 34
    • 17944383948 scopus 로고    scopus 로고
    • Identifying toxic mechanisms using dna microarrays: Evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor
    • in press
    • Waring JF, Gum R, Morfitt D, Jolly RA, Ciurlionis R, Heindel M, Gallenberg L, Buratto B, Ulrich RG: Identifying toxic mechanisms using dna microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor. Toxicology (2002) in press
    • (2002) Toxicology
    • Waring, J.F.1    Gum, R.2    Morfitt, D.3    Jolly, R.A.4    Ciurlionis, R.5    Heindel, M.6    Gallenberg, L.7    Buratto, B.8    Ulrich, R.G.9
  • 39
    • 0034040714 scopus 로고    scopus 로고
    • Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gone expression in human blood cells
    • Krovat BC, Tracy JH, Omiecinski CJ: Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gone expression in human blood cells. Toxicol Sci (2000) 55:352-360.
    • (2000) Toxicol. Sci , vol.55 , pp. 352-360
    • Krovat, B.C.1    Tracy, J.H.2    Omiecinski, C.J.3
  • 40
    • 0037122982 scopus 로고    scopus 로고
    • Toxicogenomics gains impetus
    • Gershon D: Toxicogenomics gains impetus. Nature (2002) 415:4-5.
    • (2002) Nature , vol.415 , pp. 4-5
    • Gershon, D.1
  • 41
    • 0036153531 scopus 로고    scopus 로고
    • The National Center for Toxicogenomics: Using new technologies to inform mechanistic toxicology
    • Tennant RW: The National Center for Toxicogenomics: Using new technologies to inform mechanistic toxicology. Environ Health Perspect (2002) 110:A8-Al0.
    • (2002) Environ. Health Perspect , vol.110
    • Tennant, R.W.1
  • 42
    • 0035092715 scopus 로고    scopus 로고
    • Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology
    • Fielden MR, Zacharewskii TR: Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicol Sci (2001) 60:6-10.
    • (2001) Toxicol. Sci , vol.60 , pp. 6-10
    • Fielden, M.R.1    Zacharewskii, T.R.2
  • 43
    • 0036043671 scopus 로고    scopus 로고
    • Toxicogenomics and drug discovery: Will new technologies help us produce better drugs?
    • Ulrich RG, Friend SH: Toxicogenomics and drug discovery: Will new technologies help us produce better drugs? Nat Rev Drug Discov (2002) 1:84-88.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 84-88
    • Ulrich, R.G.1    Friend, S.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.