Identifying toxic mechanisms using DNA microarrays: Evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor

Toxicology

Volumn 181-182, Issue , 2002, Pages 537-550

  Waring, Jeffrey F ^a   Gum, Rebecca ^a   Morfitt, David ^a   Jolly, Robert A ^a   Ciurlionis, Rita ^a   Heindel, Matthew ^a   Gallenberg, Lori ^a   Buratto, Bruno ^a   Ulrich, Roger G ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b ROSETTA INPHARMATICS   (United States)

Author keywords

Aryl hydrocarbon receptor; Gene expression; Hepatic toxicity; Hepatotoxin; Microarray; NF B

Indexed keywords

3 METHYLCHOLANTHRENE; A 277249; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AROCLOR 1254; AROMATIC HYDROCARBON; ASPARTATE AMINOTRANSFERASE; CELL ADHESION MOLECULE; CELL NUCLEUS RECEPTOR; CYTOCHROME P450 1A1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN INHIBITOR; PYRIDINE DERIVATIVE; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; ENZYME BLOOD LEVEL; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC DATABASE; HEPATOMEGALY; HISTOPATHOLOGY; HYPERPLASIA; HYPERTROPHY; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ISOLATION; SIGNAL TRANSDUCTION; TOXICITY TESTING; UNINDEXED SEQUENCE; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL ADHESION MOLECULES; GENE EXPRESSION; HEPATITIS, TOXIC; LIVER; LIVER FUNCTION TESTS; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOXICOLOGY;

EID: 17944383948     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00477-8     Document Type: Article

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