General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: A review

Hereditas

Volumn 136, Issue 2, 2002, Pages 89-96

  Portin, Petter ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MEMBRANE RECEPTOR; PRESENILIN 1; PRESENILIN 2; PROTEIN; REPRESSOR PROTEIN; SUPPRESSOR OF HAIRLESS PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTENNA; CELL INTERACTION; CELL NUCLEUS; CELL SURFACE; CENTRAL NERVOUS SYSTEM; DROSOPHILA MELANOGASTER; GENE ACTIVATION; GENE TARGETING; INSECT CELL; INTRACELLULAR MEMBRANE; INTRACELLULAR TRANSPORT; LEG; METAZOON; MOLECULAR GENETICS; NONHUMAN; OOCYTE DEVELOPMENT; PERIPHERAL NERVOUS SYSTEM; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CENTRAL NERVOUS SYSTEM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EXTREMITIES; MEMBRANE PROTEINS; OOCYTES; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

ANIMALIA; DROSOPHILA MELANOGASTER; HEXAPODA; INSECTA; MELANOGASTER; METAZOA;

EID: 0036619335     PISSN: 00180661     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1601-5223.2002.1360201.x     Document Type: Review

References (95)

1. Notch signaling
2. Overexpression of the m4 and m alpha genes of the E(spl)-complex antagonize Notch mediated lateral inhibition
3. Notch signalling and the initiation of neural development in the Drosophila eye
4. The embryonic development of larval muscles in Drosophila
5. A notch-independent activity of Suppressor of hairless is required for normal mechanoreceptor physiology
6. A dual requirement for neurogenic genes in Drosophila myogenesis
7. Complex function and expression of Delta during Drosophila oogenesis
8. Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch
9. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
10. Repression by Notch is required before Wingless signalling during muscle progenitor cell development in Drosophila
11. The Abruptex mutations of Notch disrupt the establishment of proneural clusters in Drosophila
12. Signal transduction and the control of gene expression
13. Lateral inhibition and cell fate during neurogenesis in Drosophila: The interactions between scute, Notch and Delta
14. Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
15. Notch signalling mediates segmentation of the Drosophila leg
16. R7 photoreceptor specification requires Notch activity
17. A role for the Drosophila neurogenic genes in mesoderm differentiation
18. Requirement for the COE transcription factor collier in formation of an embryonic muscle: Transcriptional response to Notch signalling
19. Specificity for the Hairy/Enhancer of split basic helix-loop-helix (BHLH) proteins maps outside the BHLH domain and suggests 2 separable modes of transcriptional repression
20. Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells
21. Cytosolic interaction between Deltex and Notch ankyrin repeats implicates Deltex in the Notch signaling pathway
22. Drosophila Lameduck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast development
23. Molecular interaction between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
24. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
25. Notch and Presenilin: A proteolytic mechanism emerges
26. The Suppressor of hairless protein participates in Notch receptor signaling
27. Negative complementation at the Notch locus of Drosophila melanogaster
28. Dissecting the mechanism of Suppressor of Hairless function
29. Developmental analysis of the achaete-scute system of Drosophila melanogaster
30. The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila
31. Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis
32. Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless
33. The determination of sense organs in Drosophila: Effect of the neurogenic mutations in the embryo
34. Fringe and Notch specify polar cell fate during Drosophila oogenesis
35. Early neurogenesis in wildtype Drosophila melanogaster
36. The peripheral nervous system of mutants of early neurogenesis in Drosophila melanogaster
37. A dominant-negative form of Serrate acts as a general antagonist of Notch activation
38. Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
39. Fringe, Notch, and making developmental boundaries
40. Target specifities of Drosophila Enhancer of split basic helix-loop-helix patients
41. Fringe forms a complex with Notch
42. Ligand-included cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
43. Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila
44. Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins
45. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
46. The EGF receptor and signaling pathways control the initiations of the morphogenetic furrow during Drosophila eye development
47. Notch signaling and the determination of appendage identity
48. Neuralized functions cell-autonomously to regulate a subset of Notch-dependent processes during adult Drosophila development
49. Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes
50. The Enhancer of split complex of Drosophila includes four Notch-regulated members of the Bearded gene family
51. Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte
52. Role of Notch pathway in terminal follicle cell differentiation during Drosophila oogenesis
53. Structural requirements for Notch signalling with Delta and Serrate during the development and patterning of the wing disc of Drosophila
54. Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila
55. Role of Suppressor of Hairless in the Delta-activated Notch signaling pathway
56. Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
57. On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster
58. Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye
59. Kuzbanian-mediated cleavage of Drosophila Notch
60. Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila
61. The Notch 1 receptor cleaved constitutively by a furin-like convertase
62. Delta signaling from the germ line controls the proliferation and differention of the somatic follicle cells during Drosophila oogenesis
63. Distribution and function of the lethal of acute gene product during early neurogenesis in Drosophila
64. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
65. Involvement of proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling
66. Dorsoventral lineage restriction in wing imaginal disc requires Notch
67. Notch signaling is not sufficient to define the affinity boundary between dorsal and ventral compartment
68. Spatial regulation of DELTA expression mediates NOTCH signalling for segmentation of Drosophila legs
69. Notch (spl) is deficient for inductive processes in the eye, and E(spl)D enhances split by interfering with proneural activity
70. Persistent expression of genes of the Enhancer of split complex suppresses neural development in Drosophila
71. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
72. Allelic negative complementation at the Abruptex locus of Drosophila melanogaster
73. Analysis of the negative complementation of Abruptex alleles in gynandromorphs of Drosophila melanogaster
74. Chromosomal deficiencies and the embryonic development of Drosophila melanogaster
75. The effect of certain X-chromosome deficiencies on the embryonic development of Drosophila melanogaster
76. Histogenesis, organogenesis and differentiation in the embryo of Drosophila melanogaster Meigen
77. Calcium depletion dissociates and activates heterodimeric Notch receptors
78. The establishment of segmentation in the Drosophila leg
79. Notch-mediated segmentation and growth control of the Drosophila leg
80. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
81. Drosophila oogenesis: Coordinating germ line and soma
82. Role of neurogenic genes in establishment of follicular cell fate and oocyte polarity during oogenesis in Drosophila
83. A widespread and early requirement for a novel Notch function during Drosophila embryogenesis
84. The enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidural progenitor cells
85. Notch signalling
86. Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo
87. Gene regulation in two dimensions: The proneural achaete and scute genes are controlled by combinations of axis patterning genes through a common intergenic control region
88. Presenilin is required for activity and nuclear access of Notch in Drosophila
89. Presenilin mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
90. Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila
91. Finge: Defining borders by regulating the Notch pathway
92. Deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster
93. The involvement of the Notch locus in Drosophila oogenesis
94. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants