Ageing research in Greece

Experimental Gerontology

Volumn 37, Issue 6, 2002, Pages 735-747

  Gonos, E S ^a   Agrafiotis, D ^b   Dontas, A S ^c   Efthimiopoulos, S ^d   Galaris, D ^e   Karamanos, N K ^f   Kletsas, D ^g   Kolettas, E ^e   Panayotou, G ^h   Pratsinis, H ^g   Sekeri Pataryas, K E ^g   Simoes, D ^a   Sourlingas, T G ^g   Stathakos, D ^g   Stratigos, A J ⁱ   Tavernarakis, N ^j   Trougakos, I P ^a   Tsiganos, C P ^f   Vynios, D H ^f  

^a INSTITUTE OF BIOLOGY   (Greece)

^b NATIONAL SCHOOL OF PUBLIC HEALTH   (Greece)

^c Athens Home for the Aged   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

^e UNIVERSITY OF IOANNINA   (Greece)

^f UNIVERSITY OF PATRAS   (Greece)

^g INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^h BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

ⁱ ANDREAS SYGROS HOSPITAL   (Greece)

^j INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

more..

Author keywords

Ageing; APP; Centenarians; Clusterin; Histone; Presenilin 1; Proteomics

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN; BIOLOGICAL MARKER; CLUSTERIN; HISTONE; PRESENILIN 1; PROTEASOME;

ACETYLATION; AGING; CAENORHABDITIS ELEGANS; CANCER; CELL AGING; CELL PROLIFERATION; CONNECTIVE TISSUE; CUTANEOUS PARAMETERS; DEVELOPMENT; DNA DAMAGE; FOLLOW UP; FUNCTIONAL ASSESSMENT; GENE EXPRESSION; GENE FUNCTION; GERONTOLOGICAL RESEARCH; GREECE; HOME FOR THE AGED; HUMAN; MEDICAL RESEARCH; MODEL; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEOMICS; PUBLIC HOSPITAL; REGULATORY MECHANISM; REVIEW; SENESCENCE; SOCIAL CLASS; TISSUE; ULTRAVIOLET RADIATION; UNIVERSITY;

CAENORHABDITIS; CAENORHABDITIS ELEGANS;

EID: 0036604424     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(02)00017-7     Document Type: Article

References (70)

1. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
2. Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage
3. Identification of a candidate tumor suppressor gene specifically activated during ras-induced senescence
4. Fibroblast cultures from healthy centenarians have an active proteasome
5. Protein degradation during aging: The lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems
6. Survival in the oldest old; Death risk factors in old and very old subjects
7. Comparative total mortality in 25 years in Italian and Greek middle aged rural men
8. Physical activity and nutrition in older adults
9. SIN-1-induced DNA damage in isolated human peripheral blood lymphocytes as assessed by single cell gel electrophoresis (comet assay)
10. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
11. Overexpression of Apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide
12. Study of the phorbol ester effect on Alzheimer's amyloid precursor processing: Sequence requirements, and involvement of a cholera toxin sensitive protein
13. Intracellular cAMP inhibits constitutive and phorbol ester stimulated secretory cleavage of APP
14. Cholinergic agonists stimulate secretion of soluble full length APP from neuroendocrine cells
15. Enrichment of Presenilin 1 peptides in neuronal large dense core and somatodendritic clathrin coated vesicles
16. Identification and neuron specific expression of the S182/presenilin 1 protein in human and rodent brains
17. Mechanism of amyloid β-peptide (1-42) toxicity in PC12 cells
18. On the molecular mechanism of metmyoglobin-catalyzed reduction of hydrogen peroxide by ascorbate
19. 2 with metmyoglobin
20. On the role of iron and copper ions in hydrogen peroxide-induced cellular DNA damage
21. Presenilin 1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
22. Asymptomatic Bacteriuria in freely voiding elderly subjects
23. Genetics of ageing: Lessons from centenarians
24. Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation
25. Cloning and identification of genes that associate with mammalian senescence
26. The Kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme 'prohormone thiol protease' (PTP). Colocalization of KPI/APP and PTP in secretory vesicles
27. Characterization of human vascular smooth muscle cells immortalized with a temperature-sensitive SV40 large T antigen: An in vitro model for the study of cell-cycle control and apoptosis
28. Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 years: The seven countries study
29. The growth inhibitory block of TGF-β is located close to the G1/S border in the cell cycle
30. Neutral endopeptidase-24.11 (NEP) activity in human fibroblasts during development and ageing
31. Fibroblast responses to exogenous and autocrine growth factors relevant to tissue repair
32. Suppression of decorin gene expression and induction of anchorage-independent growth by overexpression of v-src oncogene in human fibroblasts
33. Overexpression of c-erbB (EGF receptor) proto-oncogene fails to alter the lifespan or promote tumourigenic growth of normal and SV40-transformed human fibroblasts
34. V-FBR-fos oncogenes fails to rescue mammalian cells from growth arrest but affects the responses of human fibroblasts to heparin
35. Telomere length in fibroblasts and blood cells from healthy centenarians
36. 2+-dependent DNA damage in human peripheral blood lymphocytes
37. The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the APP gene
38. Characterization of the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein, Appican
39. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide
40. Distinct secretases, a cysteine and a serine protease generate the C-termini of Aβ1-40 and Aβ1-42, respectively
41. Ageing and longevity: A paradigm of complementation between homeostatic mechanisms and genetic control?
42. Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts
43. Different functions are required for initiation and maintenance of immortalisation of rat embryo fibroblasts by SV40 large T antigen
44. Autocrine growth regulation in fetal and adult human fibroblasts
45. Differential response of fetal and adult human fibroblasts to TGF-β. Mechanistic aspects and interplay with the extracellular matrix
46. A novel in vitro model of conditionally immortalized human vascular smooth muscle cells: A tool for ageing studies
47. Restoration of down-regulated PDGF receptors by TGF-β in human embryonic fibroblasts: Enhanced response during in vitro aging
48. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization
49. Mechanisms responsible for the limited and immortal phenotype in cultured mammalian cells
50. Cloning approaches for identifying aging and longevity genes in mammals
51. T-lymphocyte long-term cultures have a constant histone variant pattern during aging
52. o
53. o synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: A model study
54. Controlled ten-day antimicrobial therapy in asymptomatic bacteriuria of old age: Relations with localization, mobility and mortality
55. The molecular basis of photocarcinogenesis of the skin
56. Cell/neuron degeneration
57. Caloric restriction, protein synthesis and lifespan: A role for protein turnover?
58. Age related changes of proteoglycan subunits from sheep nasal cartilage
59. Cartilage keratan sulphate: Changes in chain length with ageing
60. Human abdominal aortic aneurism is closely associated with compositional and specific structural modifications at the glucosaminoglycan level
61. Human abdominal aortic aneurism is characterised by decreased versican consent and specific downregulation of verdsican isoform V(0)
62. Clusterin/apolipoprotein J in human ageing and cancer
63. Study of the H1 linker histone variant, H1o, during the in vitro aging of human diploid fibroblasts
64. MRNA levels of the linker histone variant, H1o, in mitotically active human diploid fibroblasts as a function of the phases of the cell cycle and cumulative population doublings
65. MRNA levels of the differentiation-associated linker histone variant, H1 zero in mitotically active and postmitotic senescent human diploid fibroblast cell populations
66. 2 from DNA damage
67. Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix
68. 2+ release from the endoplasmic reticulum