Mechanism of amyloid β-peptide (1-42) toxicity in PC12 cells

Molecular Psychiatry

Volumn 1, Issue 5, 1996, Pages 398-403

  Fagarasan, M O ^a   Efthimiopoulos, S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Arachidonic acid; Indomethacin; Phorbol ester; Protein kinase C; Signal transduction

Indexed keywords

1-OLEOYL-2-ACETYLGLYCEROL; AMYLOID BETA PROTEIN; ARACHIDONIC ACID; CARBACHOL; CARCINOGEN; CHOLINERGIC RECEPTOR STIMULATING AGENT; DIACYLGLYCEROL; GLYCEROL 2 ACETATE 1 OLEATE; INDOMETACIN; NEUROPROTECTIVE AGENT; NORDIHYDROGUAIARETIC ACID; PHORBOL ESTER; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE C; TACRINE;

ANIMAL; ARTICLE; CELL STRAIN; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; TIME;

AMYLOID BETA-PROTEIN; ANIMALS; ARACHIDONIC ACID; CARBACHOL; CARCINOGENS; CYCLOOXYGENASE INHIBITORS; DIGLYCERIDES; INDOMETHACIN; NEUROPROTECTIVE AGENTS; NORDIHYDROGUAIARETIC ACID; PARASYMPATHOMIMETICS; PC12 CELLS; PHORBOL ESTERS; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION; TACRINE; TIME FACTORS;

EID: 0030276420     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Selkoe DJ. Normal and abnormal biology of the β-amyloid precursor protein. Annu Rev Neurosci 1994; 17: 489-517.
2. Kowall NW. Beta amyloid neurotoxicity and neuronal degeneration in Alzheimer's disease. Neurobiol Aging 1994; 15: 257-258.
3. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 1993; 13: 1676-1687.
4. Kowall WN, Beal FM, Busciglio J, Duffy KL, Yankner BA. An in vivo model for the neurodegenerative effects of β amyloid and protection by substance P. Proc Natl Acad Sci USA 1991; 88: 7247-7251.
5. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 1990; 250: 279-282.
6. Fagarasan MO. Amyloid β-peptide induces free radical formation by preincubation in water: relation to its toxicity. 1995; (submitted).
7. Dyrks TE, Dyrks T, Hartman C, Beyreuthor K. Amyloido-genicity of AA4 and βA4-bearing amyloid precursor fragments by metal-catalysed oxidation. J Biol Chem 1992; 267: 18210-18217.
8. Harris ME, Hensley K, Butterfield AD, Leedle RA, Carney JM. Direct evidence of oxidative injury produced by Alzheimer's β-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 1995; 131: 193-202.
9. Hensley K, Carney JM, Mattson MP, Axenova M, Harris M, Wu JF, Floyd RA, Butterfield DA. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. PNAS USA 1994; 91: 3270-3274.
10. Mattson MP. Free radicals and disruption of nouronal ion homeostasis in AD: a role for amyloid B-peptide? Neurobiol Aging 1995; 16: 679-682.
11. Fagarasan MO, Aisen P. IL-1 and anti-inflammatory drugs modulate Aβ cytotoxicity in PC12 cells. Brain Res 1996; 723: 231-234.
12. Fowler CJ, Cowburn RF, Garlind A, Winblad B, O'Neill C. Disturbances in signal transduction mechanisms in Alzheimer's disease. Mol Cell Biochem 1995; 149-150: 287-292.
13. Shimohama S, Matsushima H. Signal transduction mechanisms in Alzheimer disease. Alzheimer Dis Assoc Disorders 1995; 9: 15-22.
14. Bergamaschi S, Binetti G, Govoni S, Wetsel WC, Battaini F, Trabucchi M, Bianchette A, Racchi M. Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci Lett 1995; 201: 1-4.
15. Govoni S, Bergamaschi S, Racchi M, Battaini F, Binetti G, Bianchetti A, Trabucchi M. Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients. Neurology 1993; 43: 2581-2586.
16. Grammas P, Moore P, Botchlet T, Hanson-Painton O, Cooper DR, Ball MJ, Roher A. Cerebral microvessels in Alzheimer's have reduced protein kinase activity. Neurobiol Aging 1995; 16: 563-569.
17. Hogan MV, Pawlowska Z, Hui-Ai Y, Kornecki E, Ehrlich YH. Surface phosphorylation by ecto-protein kinase C in brain neurons; a target for Alzheimer's β-amyloid peptides. J Neurochem 1995; 65: 2022-2030.
18. Greene LA, Tischler AS. PC12 pheochromocytoma cells in neurobiological research. Adv Cell Neurobiol 1982; 3: 373-414.
19. Sherman MS, Hawtin SR, Tailor VJ. The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by β-amyloid peptides. J Neurochem 1995; 65: 218-227.
20. Shearman MS, Ragan CI, Iverson LL. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc Natl Acad USA 1994; 91: 1470-1474.
21. Behl C, Davis J, Cole G, Schubert D. Vitamin E protects nerve cells from amyloid β toxicity. Biochem Biophys Res Commun 1992; 186: 944-950.
22. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994; 77: 817-827.
23. Vliet A, Bast A. Effect of oxidative stress on receptors and signal transmission. Chem Biol Interact 1992; 85: 95-116.
24. Nitsch RM, Slack BE, Wurtman RJ, Growdon JH. Release of Alzheimer precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 1992; 258: 304-306.
25. Nitsch RM, Slack BE, Farber SA, Schultz JG, Deng M, Kim C, Borghesani PR, Korver W, Wurtman RJ, Growdon JH. Regulation of proteolytic processing of amyloid β-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. J Neural Transm Suppl 1994; 44: 21-27.
26. Trejo J, Massamiri T, Deng T, Dewji NN, Bayneyy RM, Brown JH. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's β-amyloid precursor gene. J Biol Chem 1994; 269: 21682-21690.
27. Huang AY, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Haass C, Selkoe DJ. Activation of PKC inhibits cellular production of amyloid β-protein. J Biol Chem 1993; 268: 22959-22962.
28. Gabuzda D, Busciglio J, Yankner B. Inhibition of β-amyloid production by activation of protein kinase C. J Neurochem 1993; 61: 2326-2329.
29. Goodman Y, Mattson MS. Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide induced oxidative injury. Exp Neurol 1994; 128: 1-12.
30. Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Norstrand WE. Amyloid β-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J Neurochem 1995; 65: 931-934.