The role of IL-12 in maintaining resistance to Leishmania major

Journal of Immunology

Volumn 168, Issue 11, 2002, Pages 5771-5777

  Park, Audrey Y ^a   Hondowicz, Brian ^a   Kopf, Manfred ^a   Scott, Phillip ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; PROTEIN P35; PROTEIN P40;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; HOST PATHOGEN INTERACTION; HOST RESISTANCE; INFECTION RESISTANCE; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 0036604064     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.11.5771     Document Type: Article

References (54)

1. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
2. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
3. + T cells through IL-12 produced by Listeria-induced macrophages
4. The injection of deaggregated γ-globulins in adult mice induces antigen-specific unresponsiveness of T-helper type-1, but not type-2, lymphocytes
5. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones
6. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming
7. The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis
8. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
9. Secondary response to Listeria infection requires IFN-γ but is partially independent of IL-12
10. Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
11. IL-12 is required to maintain a Th1 response during Leishmania major infection
12. Cutting edge: IL-12 is required for the maintenance of IFN-γ production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii
13. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
14. Interleukin-12: A cytokine at the interface of inflammation and immunity
15. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
16. Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis
17. + T cells from human immunodeficiency virus-infected persons
18. Extinction of IL-12 signaling promotes Fas-mediated apoptosis of antigen-specific T cells
19. IL-12 decreases activation-induced cell death in human naive Th cells costimulated by intercellular adhesion molecule-1. I. IL-12 alters caspase processing and inhibits enzyme function
20. Dual role of the IL-12/IFN-γ axis in the development of autoimmune myocarditis: Induction by IL-12 and protection by IFN-γ
21. Recombinant interleukin 12 cures mice infected with Leishmania major
22. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective Th1 immune response
23. Identification of an infective stage of Leishmania promastigotes
24. Vaccination against cutaneous leishmaniasis in a murine model. 1. Induction of protective immunity with a soluble extract of promastigotes
25. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
26. Heterogeneity of intracellular cytokine synthesis at the singlecell level in polarized T helper 1 and T helper 2 populations
27. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
28. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
29. + T lymphocytes in vivo
30. + T cells in vivo by IL-15
31. + T-cell memory, CD45R subsets and the persistence of antigen: A unifying concept
32. Two subsets of memory. T lymphocytes with distinct homing potentials and effector functions
33. Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
34. + T cells are important for the balance between protective and pathogenic cell-mediated immunity
35. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4
36. Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells
37. In vivo priming of CD4 T cells that produce interleukin (IL)-2 but not IL-4 or interferon (IFN)-γ, and can subsequently differentiate into IL-4- or IFN-γ-secreting cells
38. Nonpolarized memory T cells
39. Separable effector T cell populations specialized for B cell help or tissue inflammation
40. Visualizing the generation of memory CD4 T cells in the whole body
41. Heterogeneity of the memory CD4 T cell response: Persisting effectors and resting memory T cells
42. + T cells during a Th2 response in Leishmania major-infected mice
43. Unequal death in T helper cell (Th1) and Th2 effectors: Th1, but not Th2, effectors undergo rapid fas/fasL-mediated apoptosis
44. Endogenous IL-12 is required for control of Th2 cytokine responses
45. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection
46. Mice lacking IL-12 develop polarized Th1 cells during viral infection
47. IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes
48. IL-12 is not required for induction of type 1 cytokine responses in viral infections
49. IL-12-independent Th1-type immune responses to respiratory viral infection: Requirement of IL-18 for IFN-γ release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes
50. IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells
51. Endogenous interleukin-12 is not required for resolution of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection in mice
52. IL-12 augments antigen-dependent proliferation of activated T lymphocytes
53. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
54. Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection