On the assessment of effects of food on the pharmacokinetics of drugs in early development

Biopharmaceutics and Drug Disposition

Volumn 23, Issue 4, 2002, Pages 165-171

  Li, Zhihong ^a   Vachharajani, Nimish N ^b   Krishna, Rajesh ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

CYP3A; Diet; Ethnicity; Food; P glycoprotein; Pharmacokinetics

Indexed keywords

CISAPRIDE; CYCLOSPORIN; CYCLOSPORIN A; DIGOXIN; ERYTHROMYCIN; FELODIPINE; INDINAVIR; METHYLPREDNISOLONE; MIDAZOLAM; NIFEDIPINE; SCOPOLAMINE; SILDENAFIL; SIMVASTATIN; THEOPHYLLINE; TRIAZOLAM; VERAPAMIL;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEVELOPMENT; DRUG HALF LIFE; DRUG METABOLISM; DRUG TRANSPORT; FOOD DRUG INTERACTION; FRUIT JUICE; HUMAN; NONHUMAN; PREDICTION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; BIOLOGICAL AVAILABILITY; CITRUS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DELAYED-ACTION PREPARATIONS; DIET; DRUG EVALUATION, PRECLINICAL; FOOD; FOOD-DRUG INTERACTIONS; HUMANS; OXIDOREDUCTASES, N-DEMETHYLATING; PHARMACOKINETICS;

EID: 0036571645     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.309     Document Type: Article

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