Membrane proteins: Shaping up

Trends in Biochemical Sciences

Volumn 27, Issue 5, 2002, Pages 231-234

  Chin, Chen Ni ^b   Von Heijne, Gunnar ^a   De Gier, Jan Willem L ^b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; MEMBRANE PROTEIN; BACTERIAL PROTEIN;

EUKARYOTIC CELL; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; STRUCTURE ANALYSIS; THERMODYNAMICS; ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

BACTERIAL PROTEINS; CELL MEMBRANE; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SUPPORT, NON-U.S. GOV'T;

EUKARYOTA;

EID: 0036558023     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(02)02082-0     Document Type: Review

References (52)

1. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes
2. Biogenesis of inner membrane proteins in Escherichia coli
3. Insertion of PsaK into the thylakoid membrane in a 'horseshoe' conformation occurs in the absence of signal recognition particle, nucleoside triphosphates, or functional Albino3
4. Helical membrane protein folding, stability, and evolution
5. Polar residues drive association of polyleucine transmembrane helices
6. Polar side chains drive the association of model transmembrane peptides
7. How membranes shape protein structure
8. Unravelling the folding of bacteriorhodopsin
9. The signal recognition particle
10. The translocon: A dynamic gateway at the ER membrane
11. Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA
12. The structure of ribosome-channel complexes engaged in protein translocation
13. Architecture of the protein-conducting channel associated with the translating 80S ribosome
14. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation
15. SecYEG assembles into a tetramer to form the active protein translocation channel
16. The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex
17. SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein
18. Escherichia coli translocase: The unravelling of a molecular machine
19. Principles of membrane protein assembly and structure
20. Membrane protein folding and oligomerization - The 2-stage model
21. A dimerization motif for transmembrane α-helices
22. The dimerization motif of the glycophorin A transmembrane segment in membranes: Importance of glycine residues
23. The GxxxG motif: A framework for transmembrane helix-helix association
24. TOXCAT: A measure of transmembrane helix association in a biological membrane
25. A transmembrane helix dimer: Structure and implications
26. Helix packing in polytopic membrane proteins: Role of glycine in transmembrane helix association
27. Statistical analysis of amino acid patterns in transmembrane helices: The GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions
28. α-H···O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions
29. Structure and function in bacteriorhodopsin: The effect of the interhelical loops on the protein folding kinetics
30. The final stages of folding of the membrane protein bacteriorhodopsin occur by kinetically indistinguishable parallel folding paths that are mediated by pH
31. Effects of chlorophyll a, chlorophyll b, and xanthophylls on the in vitro assembly kinetics of the major light-harvesting chlorophyll a/b complex, LHCIIb
32. Lipid-assisted protein folding
33. Topological 'frustration' in multi-spanning E. coli inner membrane proteins
34. Topological rules for membrane protein assembly in eukaryotic cells
35. Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning membrane proteins
36. The aqueous pore through the translocon has a diameter of 40-60 Å during cotranslational protein translocation at the ER membrane
37. Biogenesis of polytopic membrane proteins: Membrane segments of P-glycoprotein sequentially translocate to span the ER membrane
38. Different conformations of nascent polypeptides during translocation across the ER membrane
39. Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration
40. The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain
41. Sec-dependent membrane protein biogenesis: SecYEG, preprotein hydrophobicity and translocation kinetics control the stop-transfer function
42. Reconstitution of Sec-dependent membrane protein insertion: Nascent FtsQ interacts with YidC in a SecYEG-dependent manner
43. Sec-dependent membrane protein insertion: Sequential interaction of nascent FtsQ with SecY and YidC
44. YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids
45. YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase
46. YidC mediates membrane protein insertion in bacteria
47. YidC/Oxa1p/Alb3: Evolutionarily conserved mediators of membrane protein assembly
48. + channel, KAT1, into the endoplasmic reticulum membrane: Synergistic insertion of voltage-sensing segments, S3-S4, and independent insertion of pore-forming segments, S5-P-S6
49. Turns in transmembrane helices: Determination of the minimal length of a 'helical hairpin' and derivation of a fine-grained turn propensity scale
50. Formation of 'helical hairpins' during membrane protein assembly into the endoplasmic reticulum membrane. Role of the N- and C-terminal flanking regions
51. Energetics, stability, and prediction of transmembrane helices
52. Formation of cytoplasmic turns between two closely spaced transmembrane helices during membrane protein integration into the ER membrane