YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids

EMBO Reports

Volumn 2, Issue 8, 2001, Pages 709-714

  Beck, Konstanze ^a,b   Eisner, Gottfried ^a   Trescher, Dorothea ^a   Dalbey, Ross E ^c   Brunner, Josef ^d   Müller, Matthias ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HAWAII   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MANNITOL PERMEASE; MEMBRANE LIPID; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; YIDC PROTEIN;

ARTICLE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE INSERTION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN TARGETING; RIBOSOME;

BACTERIAL PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE SYSTEM; PROTEIN BIOSYNTHESIS;

EID: 0034859711     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve154     Document Type: Article

References (22)

1. Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor
2. Biogenesis of polytopic membrane proteins: Membrane segments assemble within translocation channels prior to membrane integration
3. Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle
4. Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in Escherichia coli
5. The aqueous pore through the translocon has a diameter of 40-60 Å during cotranslational protein translocation at the ER membrane
6. Membrane translocation of mitochondrially coded Cox2p: Distinct requirements for export of N and C termini and dependence on the conserved protein Oxa1p
7. The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain
8. Oxa1p, an essential component of the N-tail protein export machinery in mitochondria
9. Nascent Lep inserts into the Escherichia coli inner membrane in the vicinity of YidC, SecY and SecA
10. In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli
11. The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle
12. Chloroplast Oxa1p homolog albino3 is required for post-translational integration of the light harvesting chlorophyll-binding protein into thylakoid membranes
13. SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein
14. YidC mediates membrane protein insertion in bacteria
15. SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein
16. YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase
17. FtsY, the prokaryotic signal recognition particle receptor homologue, is essential for biogenesis of membrane proteins
18. Signal peptides open protein-conducting channels in E.coli
19. Membrane topology analysis of Escherichia coli mannitol permease by using a nested-deletion method to create mtlA-phoA fusions
20. The E.coli signal recognition particle is required for the insertion of a subset of inner membrane proteins
21. Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor
22. The Escherichia coli SRP and SecB targeting pathways converge at the translocon