The structure of ribosome-channel complexes engaged in protein translocation

Molecular Cell

Volumn 6, Issue 5, 2000, Pages 1219-1232

  Ménétret, Jean François ^a   Neuhof, Andrea ^b   Morgan, David Gene ^a,b   Plath, Kathrin ^b   Radermacher, Michael ^c   Rapoport, Tom A ^b   Akey, Christopher W ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; POLYPEPTIDE;

ARTICLE; CELL STRUCTURE; CYTOSOL; DOG; ENDOPLASMIC RETICULUM; MEMBRANE CHANNEL; NONHUMAN; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RABBIT; RIBOSOME; STRUCTURE ANALYSIS; YEAST;

EID: 0033638455     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00118-0     Document Type: Article

References (30)

1. Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle
2. Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex
3. Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes
4. Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore
5. Cryo-electron microscopy of vitrified specimens
6. SPIDER and WEB: Processing and visualization of images in 3D electron microscopy and related fields
7. A mammalian homolog of Sec61p and SecYp is associated with ribosomes and nascent polypeptides during translocation
8. Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane
9. The aqueous pore through the translocon has a diameter of 40-60 ̇ during cotranslational protein translocation at the ER membrane
10. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
11. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation
12. A tetrameric complex of membrane proteins in the endoplasmic reticulum
13. Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol
14. Membrane protein biogenesis: Regulated complexity at the endoplasmic reticulum
15. Improved methods for building protein models in electron density maps and the location of errors in these models
16. A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane
17. Protein translocation: Tunnel vision
18. The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex
19. The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation
20. A comparison of the yeast and the rabbit 80S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments
21. Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane
22. Molecular mechanism of membrane protein integration into the endoplasmic reticulum
23. Binding of signal recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction
24. Bidirectional movement of a nascent polypeptide across microsomal membranes reveals requirements for vectorial translocation of proteins
25. Signal sequence recognition in posttranslational protein transport across the yeast ER membrane
26. Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA
27. Three-dimensional reconstitution from Radon projections: Orientation alignment via Radon transforms
28. Biochemistry, molecular biology, and genetics of the oligosaccharyl transferase
29. A protein-conducting channel in the endoplasmic reticulum
30. Three dimensional structure of the frozen-hydrated flagellar filament: The left handed filament of Salmonella typhimurium