Formation of cytoplasmic turns between two closely spaced transmembrane helices during membrane protein integration into the ER membrane

Journal of Molecular Biology

Volumn 301, Issue 1, 2000, Pages 191-197

  Sääf, Annika ^a   Hermansson, Marika ^a   Von Heijne, Gunnar ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Glycosylation; Membrane protein; Topology; Transmembrane helix

Indexed keywords

ARGININE; LYSINE; MEMBRANE PROTEIN;

ARTICLE; ENDOPLASMIC RETICULUM; GLYCOSYLATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION;

EID: 0034604363     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3933     Document Type: Article

References (16)

1. The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process
2. The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis
3. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
4. Positively charged amino acids placed next to a signal sequence block protein translocation more efficiently in Escherichia coli than in mammalian microsomes
5. Regulation of translation in eukaryotic systems
6. Both lumenal and cytosolic gating of the aqueous ER translocon pore are regulated from inside the ribosome during membrane protein integration
7. Internally located cleavable signal sequences direct the formation of Semliki Forest virus membrane proteins from a polyprotein precursor
8. A turn propensity scale for transmembrane helices
9. Turns in transmembrane helices: Determination of the minimal length of a 'helical hairpin' and derivation of a fine-grained turn propensity scale
10. Molecular mechanisms of membrane protein integration into the endoplasmic reticulum
11. Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane
12. Breaking the camel's back: Proline-induced turns in a model transmembrane helix
13. Stop-transfer function of pseudo-random amino acid segments during translocation across prokaryotic and eukaryotic membranes
14. Topogenic signals in integral membrane proteins
15. Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms
16. Sequence of the leader peptidase gene of Escherichia coli and the orientation of leader peptidase in the bacterial envelope