Effect of malondialdehyde-acetaldehyde-protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells

Biochemical Pharmacology

Volumn 63, Issue 3, 2002, Pages 553-562

  Kharbanda, Kusum K ^a,b   Shubert, Kris A ^a   Wyatt, Todd A ^a,b   Sorrell, Michael F ^a,b   Tuma, Dean J ^a,b  

^a VA Alcohol Research Center   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Alcoholic liver disease; Hepatic stellate cells; MAA aducts; PKC; Urokinase type plasminogen activator

Indexed keywords

ACETALDEHYDE; ISOENZYME; MALONALDEHYDE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; UROKINASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME RELEASE; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE CELL;

ACETALDEHYDE; ANIMALS; ENZYME ACTIVATION; LIVER; MALE; MALONDIALDEHYDE; PROTEIN KINASE C; RATS; RATS, WISTAR; SERUM ALBUMIN, BOVINE; URINARY PLASMINOGEN ACTIVATOR;

EID: 0036471578     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00883-8     Document Type: Article

References (43)

1. Stellate cell activation in alcoholic fibrosis - An overview
2. Molecular mechanisms of liver fibrogenesis - A homage to the role of activated fat-storing cells
3. Hepatic stellate cells and the regulation of liver inflammation
4. In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: Evidence for predominant expression in nonparenchymal liver cells
5. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
6. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor-β: Implication for a pathogenetic role in alcohol liver fibrogenesis
7. Cellular distribution of transforming growth factor-β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis
8. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes: Analysis of gene expression, protein synthesis and proteinase activity
9. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver
10. Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis
11. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-α and TGF-β1
12. Cell-specific expression of transforming growth factor-β in rat liver: Evidence for autocrine regulation of hepatocyte proliferation
13. The plasminogen-activating system in hepatic stellate cells
14. Functions of the fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet-derived growth factor
15. Covalent binding of acetaldehyde to hepatic proteins: Role in alcoholic liver injury
16. The role of acetaldehyde adducts in liver injury
17. Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation
18. Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in livers of rats with alcoholic liver disease
19. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long term ethanol administration
20. 13C NMR spectroscopy
21. Detection of circulating antibodies to malondialdehyde-acetaldehyde (MAA) adducts in ethanol-fed rats
22. MAA adducts increase chemokine production and the expression of cell adhesion molecule, ICAM-1, in hepatic stellate cells
23. Ethanol and protein kinase C
24. Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation
25. 2+-independent protein kinase C activation in cultured rat hepatic stellate cells
26. Stimulation of macrophage urokinase expression by polyanions is protein kinase C-dependent and requires protein and RNA synthesis
27. Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan
28. Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine
29. A simple, rapid, and sensitive DNA assay procedure
30. Retinoic acid modulates extracellular urokinase-type plasminogen activator activity in DU-145 human prostatic carcinoma cells
31. Intracellular signaling pathways in stellate cell activation
32. Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate
33. Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation: Evidence for a role of protein kinase C in agonist-induced desensitization
34. Down-regulation of protein kinase C is due to an increased rate of degradation
35. Gene expression and regulation of plasminogen activator inhibitor type-1 in hepatic stellate cells of rat liver
36. The role of scavenger receptors in the innate immune system
37. Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway
38. Degradation of connective tissue matrices by macrophages. Part I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages
39. The role of plasminogen activators in the regulation of connective tissue metalloproteinases
40. Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
41. Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect
42. Contribution of sinusoidal endothelial liver cells to liver fibrosis: Expression of transforming growth factor-β1 receptors and modulation of plasmin-generating enzymes by transforming growth factor-β1
43. Acetaldehyde increases the activity and gene expression of urokinase type plasminogen activator in a hepatic stellate cell line