Acetaldehyde increases the activity and gene expression of urokinase type plasminogen activator in a hepatic stellate cell line

Toxicology

Volumn 137, Issue 1, 1999, Pages 1-11

  Rodriguez Fragoso L ^a   Alvarez, R ^b   Reyes Esparza, J A ^c   Garces M E ^b  

^a UNIVERSIDAD PANAMERICANA   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^c Instituto National de Cancerologia   (Mexico)

Author keywords

Hepatic stellate cells; Liver fibrosis; Proteolysis

Indexed keywords

ACETALDEHYDE; COLLAGEN; UROKINASE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; IN VITRO STUDY; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; STELLATE CELL; ZYMOGRAPHY;

ACETALDEHYDE; ANIMALS; CELL LINE; COLLAGEN; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; PROTEIN BIOSYNTHESIS; PROTEINS; RNA, MESSENGER; URINARY PLASMINOGEN ACTIVATOR;

EID: 0345240945     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00064-5     Document Type: Article

References (44)

1. Arthur M.J. Role of ito cells in the degradation of matrix in liver. J. Gastroenterol. Hepatol. 10:1995;S57-S62.
2. Arthur M.J. Collagenases and liver fibrosis. J. Hepatol. 22:1995;43-48.
3. Arthur M.J. Matrix degradation in liver: a role in injury and repair. Hepatology. 26:1997;1069-1071.
4. Arthur M.J., Friedman S.L. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J. Clin. Invest. 84:1989;1076-1085.
5. Arthur M.J., Stanley A., Iredale J.P., Rafferty R.M., Friedman S.L. Secretion of 72 kDa type collagenase/gelatinase by cultured human lipocytes: analysis of gene expression, protein synthesis and proteinase activity. Biochem. J. 287:1992;701-707.
6. Barry R.E, McGivan J.D. Acetaldehyde alone may initiate hepatocellular damage in acute alcoholic liver disease. Gut. 26:1985;1065-1072.
7. Bedosa P., Paradis V. Transforming growth factor-B (TGF-B): a key role in liver fibrogenesis. J. Hepathol. 22:1995;37-42.
8. Brenner D.A., Chojkier M. Acetaldehyde increases collagen gene transcription in cultured human fibroblast. J. Biol. Chem. 262:1987;17690-17695.
9. Chaves Das N.H., Vasconcelos A.M.P. Capillary gas chromatography of amino acids, including asparagine and glutamine: sensitive gas chromatographic-mass spectrometric and selected ion monitoring gas chromatographic mass spectrophotometric detection of the N,O(s)-ter-butyldimethylsilyl derivates. J. Chromatgr. 392:1987;249-258.
10. Chomzynski P., Sacchi N. Single step method of RNA isolation by acid guanidinium isothiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;157-163.
11. Friedman S.L. The cellular basis of hepatic fibrosis. N. Eng. J. Med. 328:1993;1828-1835.
12. Friedman S.L. Acetaldehyde and alcoholic fibrogenesis: fuel to the fire, but not the spark. Hepatology. 12:1990;609-612.
13. Friedman S.L. Seminars in medicine of the Beth Israel Hospital,Boston: the cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 328:1993;1828-1835.
14. Friedman S.L. Hepatic stellate cells. Prog. Liver Dis. 14:1996;101-130.
15. Friedman S.L. Molecular mechanisms of hepatic fibrosis and principles of therapy. J. Gastroenterol. 32:1997;4202-4230.
16. Geerts A., Greenwel P., Cunningham M., De Bleser P., Rogiers V., Wisse E., Rojkind M. Distribution of collagen Type I, Type III, Type IV, fibronectin and laminin transcripts in freshly isolated and purified parenchymal, endothelial, kupffer and fat storing cells. J. Hepatol. 19:1993;148-158.
17. Greenwel P., Schwartz M., Rosas M., Peyrol S., Grimaund J.A., Rojkind M. Characterization of fat storing cell lines derived from normal and CCl4-cirrhotic livers. Lab. Invest. 65:1991;644-653.
18. Gressner A.M. Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J. Hepatol. 22:1995;28-36.
19. Hoestage A., Bedossa P., Poynard T. Acetaldehyde-modified epitopes in liver biopsy specimens of alcoholic and non-alcoholic patients: localization and association with progression of liver fibrosis. Hepatology. 19:1995;367-374.
20. Iredale J.P., Goddard S., Murphy G., Benyon R.C., Arthur M.J.P. Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin. Sci. 89:1995;75-81.
21. Iredale J.P., Murphy G., Hembry R.M., Friedman S.L., Arthur M.J. Human hepatic lipocytes synthesis tissue inhibitor of metalloproteinases-1: implications for regulation of matrix degradation in liver. J. Clin. Invest. 90:1992;282-287.
22. Knittel T., Fellmar P., Ramadori G. Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver. Gastroenterology. 111:1996;745-754.
23. Lautenberg B.H., Beltzer M. Mechanisms of acetaldehyde hepatotoxicity. J. Hepatol. 7:1988;384-389.
24. Leyland H., Gentry J., Arthur M.J., Benyon C. The plasminogen activator system in hepatic stellate cells. Hepatology. 24:1996;1172-1178.
25. Lindros K.O. Alcoholic liver disease: pathobiological aspects. J. Hepatol. 23:1995;7-15.
26. Milani S., Herbst H., Schuppan D., Grappone C., Heinrichs O.E. Cellular sources of extracellular matrix proteins in normal and fibrotic liver: studies of gene expression by in situ hybridization. J. Hepatol. 22:1995;71-79.
27. Miskin R., Soreq H. Sensitive autoradiographic quantitation of electrophoretically separated proteasas. Anal. Biochem. 118:1981;252-258.
28. Mochizuki H., Nishi T., Brunner J.M., Lee S.Y., Levin V.A., Saya H. Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumor: PCR analysis of frozen-section mRNA. Mol. Carcinog. 6:1992;83-88.
29. Moshage H., Cassini A., Lieber C. Acetaldehyde selectively stimulates collagen production in fat storing cells of rat liver. Hepatology. 7:1987;680-687.
30. Moshage H.J., Janssen J.A., Franssen J.H., Hafkenschied J.C., Yap S.H. Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. J. Clin. Invest. 79:1987;1635-1641.
31. Moshage, H., Cassini, A., Lieber, C., 1990. Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 12, 511-518.
32. Murphy G., Atkinson S., Ward R., Gavrilovic J., Reynolds J. The role of plasminogen activators in the regulation of connective tissue metalloproteinases. Ann. N.Y. Acad. Sci. 667:1992;1-12.
33. Pares A., Potter J.J., Rimie L., Mezey E. Acetaldehyde activates the promotor of the mouse α-2 (I) collagen gene. Hepatology. 19:1994;498-505.
34. Rodríguez-Fragoso L., González M.P., Muriel P. Interferon alpha 2b increases fibrolysis in fibrotic livers from bile duct ligated rats: possible participation of the plasminogen activator. Pharmacology. 51:1995;341-346.
35. Rojkind M., Novikoff M., Greenwell P. et al. Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte cocultured system. Am. J. Pathol. 146:1995;1508-1520.
36. Saksela O., Rifkin D.B. Cell-associated plasminogen activation: regulation and physiological functions. Ann. Rev. Cell Biol. 4:1988;93.
37. Savolainen E.R, M.A.L., Timpl P., Lieber C.S. 1984. Acetaldehyde and lactate stimulates collagen synthesis of cultured baboon liver myofibroblast. Gastroenterology 87, 777-787.
38. Stetler-Stevenson W.G. Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix. Am. J. Pathol. 148:1996;1345-1350.
39. Takase S., Leo M.A., Nouchi T., Lieber S.C. desmin distinguishes fat-storing cells of rat liver. Hepatology. 7:1987;680-687.
40. Tae-Hyoung K, Wendy M.M., Stolz D.B., Bryon E., Michaelopoulus G.K. Extracellular matrix remodeling at early regeneration in the rat. Hepatology. 26:1997;896-904.
41. Thanassi N.M., Rokowski R.J., Sheehy J., Hart B., Asher M., Cutroneo K.R. Non selective decrease of collagen synthesis by culture fetal lung fibroblast after non lethal doses of ethanol. Biochem. Pharmacol. ,2417. 29:1980;2121.
42. Vyas S.K, Leyland H., Arthur M.J., Gentry J. Rat hepatic lipocytes synthesize and secrete stromelisyn in early primary culture. Gastroenterology. 109:1995;889-895.
43. Woessner J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93:1961;440-447.
44. Woessner J.F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 667:1991;2145-2149.