Parkinson's disease, pesticides and mitochondrial dysfunction

Trends in Neurosciences

Volumn 24, Issue 5, 2001, Pages 245-246

  Jenner, Peter ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PESTICIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL INCLUSION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENVIRONMENTAL FACTOR; GENETIC SUSCEPTIBILITY; HUMAN; MITOCHONDRIAL RESPIRATION; NERVE CELL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; STRIATONIGRAL DEGENERATION; SUBSTANTIA NIGRA;

EID: 0035341492     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01789-6     Document Type: Review

References (12)

1. Chronic systemic pesticide exposure reproduces features of Parkinson's disease
2. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus but not substantia nigra
3. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
4. Understanding cell death in Parkinson's disease
5. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity
6. Impaired clearance of oxidised proteins in neurodegenerative disease
7. The risk of Parkinson's disease with exposure to pesticides, farming, well water and rural living
8. Inhibitors of NADH-ubiquinone reductase: An overview
9. Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease
10. Mitochondrial complex I deficiency in Parkinson's disease
11. Origin and functional consequences of the complex I defect in Parkinson's disease
12. Matrilineal inheritance of complex I dysfunction in a multigeneration Parkinson's disease family