Modeling Alzheimer's disease and other proteopathies in vivo: Is seeding the key?

Amino Acids

Volumn 23, Issue 1-3, 2002, Pages 87-93

  Walker, L C ^a   Bian, F ^a   Callahan, M J ^a   Lipinski, W J ^a   Durham, R A ^a   LeVine, H ^a  

^a PFIZER INC   (United States)

Author keywords

Alzheimer's disease; Amyloid; Conformational disease; Huntington's disease; Parkinson's disease; Proteopathy; Senile plaque; Tau; Transgenic

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN EXTRACT; CHEMICAL COMPOUND; PROTEIN; PROTEIN PRECURSOR;

ALZHEIMER DISEASE; AMINO ACID DEFICIENCY; AMYLOIDOSIS; ANIMAL MODEL; BIOPHYSICS; BRAIN CORTEX; CONFERENCE PAPER; DILUTION; DISEASE ACTIVITY; DISEASE MODEL; DISEASE PREDISPOSITION; DRUG DISTRIBUTION; DRUG INFUSION; HEMISPHERE; IN VIVO STUDY; INJECTION SITE; LABORATORY TEST; MOUSE; NERVE FIBER; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOGENESIS; PHYSICAL ACTIVITY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN CHEMISTRY; BRAIN TISSUE TRANSPLANTATION; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, TRANSGENIC; TISSUE EXTRACTS;

ANIMALIA; MUS MUSCULUS;

EID: 0036386817     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-001-0113-7     Document Type: Conference Paper

References (59)

1. Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S, Coskran T, Carlo A, Seymour PA, Burkhardt JE, Nelson RB, McNeish JD (2000) Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice over-expressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97: 2910-2915
2. Arriagada PV, Growdon JH, Hedley-Whyte T, Human BT (1998) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639
3. Baker HF, Ridley RM, Duchen LW, Crow TJ, Bruton CJ (1994) Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy. Molec Neurobiol 8: 25-39
4. Berg L, McKeel DW, Miller JF, Baty J, Morris JC (1993) Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50: 349-358
5. Bian F, Nath R, Sobocinski G, Booher RN, Lipinski WJ, Callahan MJ, Pack A, Wang KK-W, Walker LC (2002) Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice. J Comp Neurol 446: 257-266
6. Bowen DM, Smith CB, White P, Davison AN (1976) Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99: 459-496
7. Brion JP, Tremp G, Octave JN (1999) Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease. Am J Pathol 154: 255-270
8. Brownlees J, Irving NG, Brion JP, Gibb BJ, Wagner U, Woodgett J, Miller CC (1997) Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes. Neuroreport 8: 3251-3255
9. Buée L, Bussière T, Buée-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 33: 95-130
10. Callahan MJ, Lipinski WJ, Bian F, Durham RA, Pack A, Walker LC (2001) Augmented senile plaque load in aged female β-amyloid precursor protein-transgenic mice. Am J Pathol 158: 1173-1177
11. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW (1996) The canine as an animal model of human aging and dementia. Neurobiol Aging 17: 259-268
12. Davies P, Maloney AJ (1976) Selective loss of cholinergic neurons in Alzheimer's disease. Lancet ii: 1403
13. Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goeder M, Davies P (2000) Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis 7: 87-98
14. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152: 307-317
15. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, et al (1995) Alzheimer-type neuropathology in transgenic mice. Nature 373: 523-527
16. Geula C, Mesulam M-M (1999) Cholinergic systems in Alzheimer disease. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 269-292
17. Giacobini E, Becker R (1994) Development of drugs for Alzheimer therapy: a decade of progress. In: Giacobini E, Becker R (eds) Alzheimer disease: therapeutic strategies. Birkhäuser, Boston, pp 1-7
18. Götz J, Chen F, Barmettler R, Nitsch RM (2001) Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem 276: 529-534
19. Götz J, Probst A, Spilantini MG, Schäfer T, Jakes R, Bürrki K, Goedert M (1995) Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J 14: 1304-1313
20. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (1998) Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nature Neurosci 1: 355-358
21. Hedera P, Whitehouse PJ (1994) Neurotransmitters in neurodegeneration. In: Calne DB (ed) Neurodegenerative disease. W.B. Saunders Company, Philadelphia, pp 97-118
22. Hof PR, Morrison JH (1999) The cellular basis of cortical disconnection in Alzheimer disease and related dementing conditions. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 207-232
23. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice. Science 274: 99-102
24. Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, Hyman BT (1997) Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 17: 7053-7059
25. Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Trojanowski JQ, Lee VM (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human isoform. Neuron 24: 751-762
26. James ND, Davis DR, Sindon J, Hanger DP, Brion JP, Miller CC, Rosenberg MP, Anderton BH, Propst F (1996) Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos. Neurobiol Aging 17: 235-241
27. Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE, Walker LC (2000) Evidence for seeding of beta-amyloid by intracerebral infusion of Alzheimer brain extracts in beta-amyloid precursor protein-transgenic mice. J Neurosci 20: 3606-3611
28. Klein WL, Krafft GA, Finch CE (2001) Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? TRENDS Neurosci 24: 219-234
29. Lee VM, Trojanowski JQ (1999) Neurodegenerative tauopathies: human disease and transgenic mouse models. Neuron 24: 507-510
30. Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Gen 25: 402-405
31. Mandelkow E-M, Mandelkow E (1998) Tau in Alzheimer's disease. Trends Cell Biol 8: 425-427
32. Martin JB (1999) Alzheimer disease: neurochemical aspects. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 263-267
33. Marx J (1992) Major setback for Alzheimer's models. Science 255: 1200-1202
34. Masliah E (1999) Transgenic animal models of Alzheimer disease. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 245-261
35. Price DL, Sisodia SS, Borchelt DR (1998) Genetic neurodegenerative diseases: The human illness and transgenic models. Science 282: 1079-1083
36. Probst A, Götz J, Wiederhold KH, Tolnay M, Mistl C, Jaton AL, Hong M, Ishihara T, Lee VM, Trojanowski JQ, Jakes R, Crother RA, Spillantini MG, Bürki K, Goedert M (2000) Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol 99: 469-481
37. Prusiner SB, Safar J, Cohen FE, De Armond SJ (1999) The prion diseases. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 161-179
38. Prusiner SB, Scott M, Foster D, Pan KM, Groth D, Mirenda C, Torchia M, Yang SL, Serban D, Carlson GA (1990) Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell 63: 673-686
39. Selkoe DJ (1999) Biology of beta-amyloid precursor protein and the mechanism of Alzheimer disease. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 293-310
40. Sisodia SS, Martin LJ, Walker LC, Borchelt DR, Price DL (1995) Cellular and molecular biology of Alzheimer's disease and animal models. Neurodegen Dis 5: 59-68
41. Sommer B (1998) Recent advances in transgenic model development for Alzheimer's disease. Exp Opin Invest Drugs 7: 2017-2025
42. Spillantini MG, Goedert M (1998) Tau protein pathology in neurodegenerative diseases. TRENDS Neurosci 21: 428-433
43. Spittaels K, Van den Haute C, Can Dorpe J, Bruynseels K, Vandezande K, Laenen I, Geerts H, Mercken M, Van Lommel A, Loos R, Van Leuven F (1999) Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol 155: 2153-2165
44. St. George-Hyslop PH (1999) Molecular Genetics of Alzheimer disease. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 311-326
45. Stalder M, Phinney A, Probst A, Sommer B, Staufenbiel M, Jucker M (1999) Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am J Pathol 154: 1673-1684
46. Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Bürki K, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94: 13287-13292
47. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580
48. Tesseur I, Van Dorpe J, Bruynseels K, Bronfman F, Sciot R, Van Lommel A, Van Leuven F (2000) Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein neurons of brain and spinal cord. Am J Pathol 157: 1494-1510
49. Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Mooechars D, Van Leuven F (2000) Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol 156: 951-964
50. Tolnay M, Probst A (1999) Tau protein pathology in Alzheimer's disease and related disorders. Neuropath Appl Neurobiol 25: 171-187
51. Walker LC (1997a) Animal models and Alzheimer's disease. Alzheimer's Dis Invest Drugs (ID) Res Alert 2: 133-139
52. Walker LC (1997b) Animal models of cerebral β-amyloid angiopathy. Brain Res Rev 25: 70-84
53. Walker LC (2000) Cerebral amyloid angiopathy in aged dogs and nonhuman primates. In: Verbeek MM, Vinters HV (eds) Cerebral amyloid angiopathy in Alzheimer's disease and related disorders. Kluwer Academic Publishers, Boston, pp 313-324
54. Walker LC, Callahan MC, Bian F, Durham RA, Roher AE, Lipinski WJ (submitted) Exogenous induction of cerebral β-amyloidosis in βAPP-transgenic mice.
55. Walker LC, Cork LC (1999) The neurobiology of aging in nonhuman primates. In: Terry RD, Katzman R, Bick KL, Sisodia SS (eds) Alzheimer disease. Lippincott Williams & Wilkins, Philadelphia, pp 233-243
56. Walker LC, LeVine III H (2000a) The cerebral proteopathies. Neurobiol Aging 21: 559-561
57. Walker LC, LeVine III H (2000b) The cerebral proteopathies: Neurodegenerative disorders of protein conformation and assembly. Molec Neurobiol 21: 83-95
58. Walker LC, Price DL, Voytko ML, Schenk DB (1994) Labeling of cerebral amyloid in vivo with a monoclonal antibody. J Neuropath Exp Neurol 53: 377-383
59. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215: 1237-1239