A mutational analysis of the 5′ HoxD genes: Dissection of genetic interactions during limb development in the mouse

Development

Volumn 122, Issue 4, 1996, Pages 1175-1185

  Davis, Allan Peter ^a   Capecchi, Mario R ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Gene targeting; Genetic interaction; HoxD genes; Limb development; Mouse

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARPAL BONE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; FINGER MALFORMATION; GENE DISRUPTION; GENE TARGETING; HETEROZYGOTE; HOMEOBOX; LIMB DEVELOPMENT; LIMB MALFORMATION; METACARPAL BONE; MOUSE; MOUSE MUTANT; NONHUMAN; PHALANX; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CARPAL BONES; CROSSES, GENETIC; FORELIMB; GENE EXPRESSION; GENE TARGETING; GENES, HOMEOBOX; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HUMANS; METACARPUS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHENOTYPE; TOES; TRANSCRIPTION FACTORS;

ANIMALIA; TETRAPODA; VERTEBRATA;

EID: 0029963585     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Capecchi, M. R. (1989). Altering the genome by homologous recombination. Science 244, 1288-1292.
2. Cohn, M. J., Izpisúa-Belmonte, J.-C., Abud, H., Heath, J. K. and Tickle, C. (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.
3. Condie, B. G. and Capecchi, M. R. (1994) Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature 370, 304-307.
4. Cusic, A. M. and Dagg, C. P. (1985). Spontaneous and retinoic acid-induced postaxial polydactyly in mice. Teratology 31, 49-59.
5. Davis, A. P. and Capecchi, M. R. (1994). Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development 120, 2187-2198.
6. Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. and Capecchi, M. R. (1995). Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791-795.
7. Deng, C., Thomas, K. R. and Capecchi, M. R. (1993) Location of crossovers during gene targeting with insertion and replacement vectors. Mol. Cell. Biol. 13, 2134-2140.
8. Doué, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambcm, P. and Duboule, D. (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs Cell 75, 431-441
9. Dollé, P., Izpisúa-Belmonte, J. C., Boncinelli, E. and Duboule, D. (1991a). The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. Mech. Dev. 36, 3-13.
10. Dollé, P., Izpisúa-Belmonte, J.-C., Brown, J. M., Tickle, C. and Duboule, D. (1991b). Hox-4 genes and the morphogenesis of mammalian genitalia. Gents Dev. 5, 1767-1776.
11. Dollé, P., Izpisúa-Belmonte, J.-C., Falkenstein, H., Renucci, A. and Duboule, D. (1989). Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation. Nature 342, 767-772.
12. Duboule, D. (1992). The vertebrate limb: a model system to study the Hox/HOM gene network during development and evolution. BioEssavs 14, 375-384.
13. Duboule, D. (1994). Guidebook to the Homeobox Genes. New York: Oxford University Press, Inc.
14. Duboule, D. (1995). Vertebrate Hox genes and proliferation: an alternative pathway to homeosis? Curr. Opin. Gener Dev. 5, 525-528.
15. Fallon, J. F., Lopez, A., Ros, M. A., Savage, M. P., Olwin, B. B. and Simandl, B. K. (1994). FGF-2. Apical ectodermal ridge growth signal for chick limb development Science 264, 104-107.
16. Favier, B., LeMeur, M., Chambon, P. and Dollé, P. (1995). Axial skeletal homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc. Natl. Acad. Sci. USA 92, 310-314.
17. Fawcett, D., Pasceri, P., Fraser, R., Colbert, M., Rossant, J. and Giguere, V. (1995). Postaxial polydactyly in forelimbs of CRABP-II mutant mice. Development 121, 671-679.
18. Hinchliffe, J. R. (1994). Evolutionary developmental biology of the terrapod limb. Development Supplement 163-168.
19. Hinchliffe, J. R. and Horder, T. J. (1993). Lessons from extra digits. In Limb Development and Regeneration (ed. J. F. Fallon, P F. Goetinck, R O. Kelley and D. L. Stocum) pp. 113-126. New York: John Wiley & Sons, Inc.
20. Hinchliffe, J. R. and Johnson, D. R. (1980). The Development of the Vertebrate Limb. New York: Oxford University Press, Inc.
21. Hinchliffe, R. (1991). Developmental approaches to the problem of transformation of limb structure in evolution. In Developmental Patterning of The Vertebrate Limb (ed. J. R. Hinchliffe, J. M. Hurle and D. Summerbell) pp. 313-323 New York: Plenum Publishing Corp.
22. Horan, G. S. B., Ramírez-Solis, R., Featherstone, M. S., Wolgemuth, D. J., Bradley, A. and Behringer, R. R. (1995). Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev. 9, 1667-1677.
23. Hurle, J. M., Macias, D., Ganan, Y., Ros, M. A. and Fernandez-Teran, M. A. (1991). The interdigital spaces of the chick leg bud as a model for analysing limb morphogenesis and cell differentiation. In Developmental Patterning of the Vertebrate Limb (ed J. R. Hinchliffe, H M. Hurle & D. Summerbell) pp. 249-259. New York: Plenum Publishing Corp.
24. Izpisúa-Belmonte, J.-C., Falkenstein, H., Dollé, P., Renucci, A. and Duboule, D. (1991) Murine genes related to the Drosophila AbdB homeotic gene are sequentially expressed during development of the posterior part of the body. EMBO J. 10, 2279-2289.
25. Izpisúa-Belmonte, J. C. and Duboule, D. (1992). Homeobox genes and pattern formation in the venebrate limb. Dev. Biol. 152, 26-36.
26. Lampron, C., Rochette-Egly, C., Gorry, P., Dollé, P., Mark, M., Lufkin, T., LeMeur, M. and Chambon, P. (1995). Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal. Development 121, 539-548.
27. Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., and Tabin, C. (1994). Sonic hedgehog and fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developins limb bud. Cell 79, 993-1003.
28. Mansour, S. L., Thomas, K. R. and Capecchi, M. R. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general stratesy for targeting mutations to non-selectable genes. Nature 336, 348-352.
29. Muller, G. B. (1991). Evolutionary transformation of limb pattern: heterochrony and secondary fusion. In Developmental Patterning of the Vertebrate Limb (ed. J. R Hinchliffe, H. M. Hurle and D. Summerbell) pp. 395-405. New York: Plenum Publishing Corp.
30. Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R. (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the hmb. Cell 75, 579-587.
31. Oster, G. F., Shubin, N., Murray, J. D. and Alberch, P. (1988). Evolution and morphogenetic rules: the shape of the vertebrate limb in ontogeny and phylogeny. Evolution 42, 862-884.
32. Parr, B. A. and McMahon, A. P. (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353.
33. Rancourt, D. E., Tsuzuki, T. and Capecchi, M. R. (1995 ). Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev. 9, 108-122.
34. Ruddle, F. H., Bartels, J. L., Bentley, K. L., Kappen, C., Murtha, M. T. and Pendleton, J. W. (1994). Evolution of Hox genes. Annu. Rev. Genet. 28, 423-442.
35. Shubin, N. H. and Alberch, P. (1986). A morphogenetic approach to the origin and basic organization of the tetrapod limb. Evol. Biol. 20, 319-387.
36. Small, K. M. and Potter, S. S. (1993). Homeotic transformations and limb defects in Hoxa-11 mutant mice. Genes Dev. 7, 2318-2328.
37. Solursh, M. (1984). Ectoderm as a determinant of early tissue pattern in the limb bud. Cell Differ. 15, 17-24.
38. Tabin, C. J. (1995). The initiation of the limb bud. growth factors. Hox genes and retinoids. Cell 80, 671-674.
39. Thomas, K. R. and Capecchi, M. R. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512.
40. Thomas, K. R., Deng, C, and Capecchi, M. R. (1992). High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell. Biol. 12, 2919-2923.
41. Tickle, C. and Eicheie, G. (1994). Vertebrate limb development. Annu. Rev. Cell Biol. 10, 121-152.
42. Wurst, V., Auerbach, A. B. and Joyner, A. L. (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.
43. Yang, Y. and Niswander, L. (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteropostenor patterning. Cell 80, 939-947.
44. Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Karaeda, T., Iba, H. and Kuroiwa, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509-2522.