Ectopic ICER expression in pituitary corticotroph AtT20 cells: Effects on morphology, cell cycle, and hormonal production

Molecular Endocrinology

Volumn 11, Issue 10, 1997, Pages 1425-1434

  Lamas, Monica ^a   Molina, Carlos ^a   Foulkes, Nicholas S ^a   Jansen, Erik ^b   Sassone Corsi, Paolo ^a,c  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c Institut de Genetique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM CHLORIDE; CORTICOTROPIN; CYCLIC AMP; CYCLIN A; FORSKOLIN; METALLOTHIONEIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; HORMONE SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRESSOR GENE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0030860303     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.10.9987     Document Type: Article

References (52)

1. Dumont JE, Jauniaux JC, Roger PP 1989 The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem Sci 14:67-71
2. Lauder JM 1993 Neurotransmitters as growth regulatory signals: role of receptors and second messengers. Trends Neurosci 16:233-240
3. Lamb NJC, Cavadore JC, Labbe JC, Maurer RA, Fernandez A 1991 Inhibition of cAMP-dependent protein kinase plays a role in the induction of mitosis and nuclear envelope breakdown in mammalian cells. EMBO J 10:1523-1533
4. Grieco D, Porcellini A, Avvedimento EV, Gottesman ME 1996 Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to interphase. Science 271:1718-1723
5. Florio T, Scorizello A, Fattore M, D'Alto V, Salzano S, Rossi G, Berlingieri MT, Fusco A, Schettini G 1996 Somatostatin inhibits PC C13 thyroid cell proliferation through the modulation of phosphotyrosine activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene. J Biol Chem 271:6129-6136
6. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR 1991 Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350:622-624
7. Burton FH, Hasel KW, Bloom FE, Sutcliffe JG 1991 Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. Nature 350:74-77
8. Desdouets C, Matesic G, Molina CA, Foulkes NS, Sassone-Corsi P, Brechot C, Sobczac-Thepot J 1995 Cell cycle regulation of Cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM. Mol Cell Biol 15:3301-3309
9. Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksen K, Dierich A, Parvinen M, Sassone-Corsi P 1996 Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380:159-162
10. Sassone-Corsi P 1995 Transcription factors responsive to cAMP. Annu Rev Cell Dev Biol 11:355-377
11. Gonzalez GA, Montminy MR 1989 Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at Ser 133. Cell 59:675-680
12. de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P 1993 Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12:3903-3911
13. Quinn PG 1993 Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription. J Biol Chem 268:16999-17009
14. Brindle P, Linke S, Montminy M 1993 Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. Nature 364:821-824
15. Molina CA, Foulkes NS, Lalli E, Sassone-Corsi P 1993 Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 75:875-886
16. Stehle JH, Foulkes NS, Molina CA, Simonneaux V, Pévet P, Sassone-Corsi P 1993 Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature 365:314-320
17. Lamas M, Sassone-Corsi P 1997 The dynamics of the transcriptional response to cAMP: recurrent inducibility and refractory phase. Mol Endocrinol 11:0000-0000
18. Lalli E, Sassone-Corsi P 1995 Thyroid-stimulating hormone (TSH)-directed induction of the CREM gene in the thyroid gland participates in the long-term desensitization of the TSH receptor. Proc Natl Acad Sci USA 92:9633-9637
19. Monaco L, Foulkes NS, Sassone-Corsi P 1995 Pituitary follicle-stimulating hormone (FSH) induces CREM gene expression in Sertoli cells: involvement in long-term desensitization of the FSH receptor. Proc Natl Acad Sci USA 92:10673-10677
20. Foulkes NS, Duval G, Sassone-Corsi P 1996 Adaptative inducibility of CREM as transcriptional memory of circadian rhythms. Nature 381:83-85
21. Borrelli E, Heyman R, Arias C, Sawchenko P, Evans RM 1989 Transgenic mice with inducible dwarfism. Nature 339:538-541
22. van Wijk PA, van Neck JW, Rijnberk A, Croughs RJM, Mol JA 1995 Proliferation of the murine corticotroph tumor cell line AtT20 is affected by hypophysiotrophic hormones, growth factors and glucocorticoids. Mol Cell Endocrinol 111:13-19
23. Schecterson LC, McKnight GS 1991 Role of cyclic adenosine 3′, 5′-monophosphate-dependent Protein kinase in hormone-stimulated β-endorphin secretion in AtT20 cells. Mol Endocrinol 5:170-178
24. Devi L, 1992 Secretion and regulation of a neuropeptide-processing enzyme by AtT20 cells. Endocrinology 131:1930-1935
25. Rougon G, Barbet J, Reisine T 1989 Protein phosphorylation induced by phorbol esters and cyclic AMP on anterior pituitary cells: possible role in adrenocorticotropin release and synthesis. J Neurochem 52:1270-1278
26. Axelrod J, Reisine TD 1984 Stress hormones: their interaction and regulation. Science 224:452-459
27. Yu SF, VonRuden T, Kantoff PW, Garber C, Seiberg M, Ruther U, Anderson WF, Wagner EF, Gilboa E 1986 Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci USA 83:3194-3198
28. Pines J 1994 The cell cycle kinases. Semin Cancer Biol 5:305-313
29. Reed SI 1991 G1-specific cyclins: in search of an S-phase-promoting factor. Trends Genet 7:95-99
30. Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D 1989 The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57:393-401
31. Hunt T, Luca FC, Ruderman JV 1992 The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo. J Cell Biol 116:707-724
32. Amon A, Tyers M, Futcher B, Nasmyth K 1993 Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74:993-1007
33. Sewing A, Bürger C, Brüsselbach S, Sohalk C, Lucibello FC, Müller R 1993 Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cAMP. J Cell Sci 104:545-554
34. Yoshizumi M, Hshieh CM, Zhou F, Tsai JC, Patterson C, Perrella MA, Lee ME 1995 The ATF site mediates down-regulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Mol Cell Biol 15:3266-3272
35. Zwicker J, Lucibello FC, Wolfraim LA, Gross C, Truss M, Engeland K, Müller R 1995 Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J 14:4514-4522
36. Barlat I, Henglein B, Plet A, Lamb N, Fernandez A, McKenzie F, Poysségur J, Vie A, Blanchard JM 1995 TGF-β1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways. Oncogene 11:1309-1318
37. Matsuuchi L, Buckley KM, Lowe AW, Kelly RB 1988 Targeting of secretory vesicle to cytoplasmic domains in AtT20 and PC12 cells. J Cell Biol 106:239-251
38. Kraus J, Höllt V, 1995 Identification of a cAMP-response element on the human proopiomelanocortin gene upstream promoter. DNA Cell Biol 14:103-110
39. Murphy EP, Conneely OM 1997 Neuroendocrine regulation of the hypothalamic-pituitary-adrenal axis by the nurr1/nurr77 subfamily of nuclear receptors. Mol Endocrinol 16:39-47
40. Bloomquist BT, Eipper BA, Mains RE 1992 Pro-hormone converting enzymes: regulation and evaluation of function using antisense RNA. Mol Endocrinol 5:2014-2024
41. Jansen E, Ayoubi TAY, Meulemans SMP, Van de Ven WJM 1995 Neuroendocrine-specific expression of the human prohormone convertase 1 gene. J Biol Chem 270:15391-15397
42. Servillo G, Penna L, Foulkes NS, Viola Magni M, Della Fazia MA, Sassone-Corsi P 1997 Cyclic AMP signalling pathway and cellular proliferation: induction of CREM during liver regeneration. Oncogene 14:1601-1606
43. Foulkes NS, Borrelli E, Sassone-Corsi P 1991 CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP induced transcription. Cell 64:732-749
44. Guadagno TM, Ohtsubo M, Roberts JM, Assoian RK 1993 A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262:1572-1575
45. Benjannet S, Rondeau N, Day R, Chretien M, Seidah NG 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci USA 88:5297-5301
46. Jansen E, Ayoubi TAY, Meulemans SMP, Van de Ven W 1997 Cell type-specific protein-DNA interactions at the cAMP response elements of the prohormone convertase 1 promoter. J Biol Chem 24:2500-2508
47. Gorman C, Padmanabhan R, Howard BH 1983 High efficiency DNA transformation of primate cells. Science 221:551-553
48. Heintz N, Sive HL, Roeder RG 1983 Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle. Mol Cell Biol 3:539-550
49. Draetta G, Beach D 1988 Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54:17-26
50. Chomczynski P, Sacchi N, 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159
51. Foulkes NS, Mellström B, Benusiglio E, Sassone-Corsi P 1992 Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature 355:80-84
52. Henglein B, Chenivesse X, Wang J, Eick D, Brechot C 1994 Structure and cell cycle regulated transcription of the human cyclin A gene. Proc Natl Acad Sci USA 91:5490-5494