Disruption of mesodermal enhancers for Igf2 in the minute mutant

Development

Volumn 129, Issue 7, 2002, Pages 1657-1668

  Davies, Karen ^a   Bowden, Lucy ^a   Smith, Paul ^a   Dean, Wendy ^a   Hill, David ^a   Furuumi, Hiroyasu ^a   Sasaki, Hiroyuki ^a   Cattanach, Bruce ^a   Reik, Wolf ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

H19; Igf2; Imprinted genes; Mouse

Indexed keywords

HISTONE; SOMATOMEDIN B;

3' UNTRANSLATED REGION; ALLELE; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENDODERM; ENHANCER REGION; FETUS; FETUS GROWTH; GENE CLUSTER; GENE DISRUPTION; GENE EXPRESSION; GENE SILENCING; GENOME IMPRINTING; IN VIVO STUDY; INHERITANCE; MESODERM; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PLACENTA; PRIORITY JOURNAL; REVIEW; SKELETAL MUSCLE; TONGUE;

ANIMALS; DNA METHYLATION; EMBRYONIC AND FETAL DEVELOPMENT; ENHANCER ELEMENTS (GENETICS); FEMALE; FETAL GROWTH RETARDATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOMIC IMPRINTING; IN SITU HYBRIDIZATION, FLUORESCENCE; INSULIN-LIKE GROWTH FACTOR II; INVERSION, CHROMOSOME; MALE; MESODERM; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MULTIGENE FAMILY; MUSCLES; MUTATION; PREGNANCY; RNA, UNTRANSLATED;

MAMMALIA;

EID: 0036333199     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
2. Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb
3. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
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5. A simplified in situ hybridisation protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections
6. Mechanisms of genomic imprinting
7. Large deletions and other gross forms of chromosome imbalance compatible with viability and fertility in the mouse
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11. Elucidation of the minimal sequence required to imprint H19 transgenes
12. Differences in the localization and morphology of chromosomes in the human nucleus
13. Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site
14. Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: Association with aberrant phenotypes
15. Parental imprinting of the mouse insulin-like growth factor II gene
16. An upstream repressor element plays a role in Igf2 imprinting
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18. The two-domain hypothesis in Beckwith-Wiedemann syndrome
19. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
20. Parental-origin-specific epigenetic modification of the mouse H19 gene
21. Imprinting and the epigenetic asymmetry between parental genomes
22. Tumour-suppressor activity of H19 RNA
23. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
24. Relative abundance and molecular size of immunoreactive insulin-like growth factors I and II in human fetal tissues
25. Staining for β-galactosidase (lacZ) Activity
26. CpG methylation regulates the Igf2/H19 insulator
27. Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting
28. Igf2 imprinting does not require its own DNA methylation or H19 RNA
29. A transcriptional insulator at the imprinted H19/Igf2 locus
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31. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
32. Cooperation between elements of an organ-specific transcriptional enhancer in animals
33. Simplified mammalian DNA isolation procedure
34. An enhancer deletion affects both H19 and Igf2 expression
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36. The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans
37. Beckwith-Wiedemann syndrome: Imprinting in clusters revisited
38. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
39. Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer
40. Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedermann syndrome region in chromosome 11p15.5
41. Imprinting mechanisms in mammals
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43. Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function
44. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
45. The sins of the fathers and mothers: Genomic imprinting in mammalian development
46. A paternal-specific methylation imprint marks the alleles of the mouse H19 gene
47. Epigenetic gene silencing in cancer