A transcriptional insulator at the imprinted H19/Igf2 locus

Genes and Development

Volumn 14, Issue 15, 2000, Pages 1908-1919

  Kaffer, C R ^a   Srivastava, M ^a   Park, K Y ^a   Ives, E ^a   Hsieh, S ^a   Batlle, J ^a   Grinberg, A ^a   Huang, S P ^a   Pfeifer, K ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Chromatin; Epigenetics; Methylation; Muscle; Transcription

Indexed keywords

CIS ACTING ELEMENT;

ALLELE; ARTICLE; ENHANCER REGION; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENOME IMPRINTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; CHROMOSOME MAPPING; DNA METHYLATION; ENHANCER ELEMENTS (GENETICS); GENE SILENCING; GENOMIC IMPRINTING; INSULIN-LIKE GROWTH FACTOR II; MESODERM; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUTATION; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, UNTRANSLATED; SEQUENCE DELETION; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 0033870806     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Imprinting of Igf2 and H19 from a 130 kb YAC transgene
2. Appropriate expression of the mouse H19 gene utilizes three or more distinct enhancer regions spread over more than 130 kb
3. Parental imprinting of the mouse H19 gene
4. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
5. Stopped at the border: Boundaries and insulators
6. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse
7. A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice
8. Ectopic expression of the H19 gene in mice causes prenatal lethality
9. Modulation of enhancer-promoter interactions by insulators in the Drosophila embryo
10. Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements
11. A 5' element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
12. Interactions of retrotransposons with the host genome: The case of the gypsy element of Drosophila
13. Parental imprinting of the mouse insulin-like growth factor II gene
14. A 5' differentially methylated sequence and the 3'-flanking region are necessary for H19 transgene imprinting
15. Parental-origin-specific epigenetic modifications of the mouse H19 gene
16. DNA position-specific repression of transcription by a Drosophila zinc-finger protein
17. Imprinting of mouse Kvlqt1 is developmentally regulated
18. Chromatin conformation of the H19 epigenetic mark
19. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain
20. A position-effect assay for boundaries of higher order chromosomal domains
21. A group of scs elements function as domain boundaries in an enhancer-blocking assay
22. Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene
23. Single nucleotide primer extension to detect genetic diseases: Experimental application to hemophilia B (factor X) and cystic fibrosis
24. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
25. Disruption of imprinting caused by deletion of the H19 gene region in mice
26. An enhancer deletion affects both H19 and Igf2 expression
27. Positive-negative selection gene targeting with the diptheria toxin A-chain gene in mouse embryonic stem cells
28. The ontogeny of the H19 methylation imprint
29. The structural H19 gene is required for transgene imprinting
30. The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects
31. Parental imprinting: Potentially active chromatin of the repressed maternal allele of the mouse Insulin-like Growth Factor II (Igf2) gene
32. Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase
33. Enhancer competition between H19 and Igf2 does not mediate their imprinting
34. Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes
35. Parental imprinting studies by allele-specific primer extension after PCR: Paternal X chromosome-linked genes are transcribed prior to preferential paternal X chromosome inactivation
36. H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory element upstream of H19
37. Putting boundaries on silence
38. Biallelic expression of imprinted genes in the mouse germ line: Implications for erasure, establishment, and mechanisms of genomic imprinting
39. Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene
40. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
41. A paternal-specific methylation imprint marks the alleles of the mouse H19 gene
42. A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development
43. The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains
44. Location of enhancers is essential for imprinting of H19 and Igf2
45. Two regulatory domains flank the mouse H19 gene