Seizure-induced hippocampal damage in the mature and immature brain

Epileptic Disorders

Volumn 4, Issue 2, 2002, Pages 83-97

  Lado, Fred A ^a   Laureta, E C ^a   Moshé, Solomon L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Age; Cognitive deficits; Epilepsy; Hippocampus; Neurophysiology; Neuroprotection; Seizure; Status epilepticus

Indexed keywords

CALCIUM; ESTROGEN; SEX HORMONE;

ADULT; ANIMAL MODEL; BABOON; BRAIN INJURY; BRAIN MATURATION; EPILEPTIC STATE; EPILEPTOGENESIS; FEBRILE CONVULSION; HIPPOCAMPUS; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NEUROANATOMY; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; RISK ASSESSMENT; SCLEROSIS; SEIZURE;

ADULT; AGE FACTORS; CALCIUM; CHILD, PRESCHOOL; EPILEPSY, TEMPORAL LOBE; ESTROGENS; HIPPOCAMPUS; HUMANS; RESEARCH; SCLEROSIS; SEIZURES; STATUS EPILEPTICUS;

EID: 0036310070     PISSN: 12949361     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (213)

1. Mesial temporal sclerosis: Pathogenesis and significance
2. Epilepsy and neuron loss in the hippocampus
3. Ammonshornbefunde bei epileptikern
4. Etiology and pathogenesis of temporal lobe epilepsy
5. Hippocampal sclerosis revisited
6. Childhood-onset epilepsy with and without preceding febrile seizures
7. Incidence and prevalence
8. The natural history of febrile seizures
9. Myoclonic astatic epilepsy of early childhood
10. Severe myoclonic epilepsy in infants
11. Functional anatomy of human hippocampal formation and related structures
12. Studies on the structure of the cerebral cortex II. Continuation of the study of the ammonic system
13. Hippocampus
14. Mossy fiber synaptic reorganization in the epileptic human temporal lobe
15. Spiney nonpyramidal neurons in the CA3 region of the rat hippocampus are glutamate-like immunoreactive and receive convergent mossy fiber input
16. Axon arbors and synaptic connections of hippocampal mossy cells in the rat in vivo
17. Positive feedback from hilar mossy cells to granule cells in the dentate gyrus revealed by voltage-sensitive dye and microelectrode recording
18. Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats
19. GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus
20. Ultra-structural localization of neurotransmitter immunoreactivity in mossy cell axons and their synaptic targets in the rat dentate gyrus
21. Synaptic connectivity of distinct hilar interneuron subpopulations
22. Commissural fibers terminate on non-pyramidal neurons in the guinea pig hippocampus - A combined Golgi/EM degeneration study
23. Direct commissural connections to the basket cells of the hippocampal dentate gyrus: Anatomical evidence for feed-forward inhibition
24. Electrophysiological evidence that dentate hilar mossy cells are excitatory and innervate both granule cells and interneurons
25. Synchronization of inhibitory neurones in the guinea-pig hippocampus in vitro
26. The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy
27. Hippocampus
28. Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropatho-logical study of the brain in epilepsy, with particular reference to the temporal lobes
29. Neuropathology of status epilepticus in humans
30. Mesial temporal lobe epilepsy
31. Hippocampal sclerosis: Development in adult life
32. Hippocampal pyramidal cell loss in human status epilepticus
33. MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus
34. Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy
35. Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed, artificially ventilated baboons
36. Prolonged epileptic seizures in primates: Ischemic cell change and its relation to ictal physiological events
37. Status epilepticus in well-oxygenated rats causes neuronal necrosis
38. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology
39. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies
40. Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat
41. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
42. Mini-review; kainic acid as a tool for the study of temporal lobe epilepsy
43. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
44. Kainic acid induced limbic seizures: Metabolic, behavioral, electroencephalographic and neuropathological correlates
45. Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide
46. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
47. Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats
48. Long-term effects of intrahippocampal kainic acid injection in rats: A method for inducing spontaneous recurrent seizures
49. Limbic seizures produced by pilocarpine in rats: A behavioural, electroence-phalographic and neuropathological study
50. The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus
51. Long-term effects of pilocarpine in rats: Structural damage of the brain triggers kindling and spontaneous recurrent seizures
52. Spontaneous recurrent seizures in rats: An experimental model of partial epilepsy
53. Self-sustaining limbic status epilepticus induced by "continuous" hippocampal stimulation: Electrographic and behavioral characteristics
54. Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus
55. Perforant path stimulation in rats produces seizures, loss of hippocampal neurons, and a deficit in spatial mapping which are reduced by prior MK-801
56. Self-sustaining status epilepticus after a brief electrical stimulation of the perforant path: A 2-deoxyglucose study
57. Self-sustaining status epilepticus after brief electrical stimulation of the perforant path
58. Brief seizure episodes induce longterm potentiation and mossy fibre sprouting in the hippocampus
59. Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region
60. Recurrent excitatory circuits by "sprouted" mossy fibers into the fascia dentata of human hippocampal epilepsy
61. Synaptic reorganization in the hippocampus induced by abnormal functional activity
62. Status epilepticus: Epidemiologic considerations
63. Synaptic reorganization by mossy fibers in human epileptic fascia dentata
64. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy
65. Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers
66. Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats
67. Status epilepticus-induced neuronal injury and network reorganization
68. Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The "Dormant Basket Cell" hypothesis and its possible relevance to temporal lobe epilepsy
69. Kainic acid induced seizures enhance dentate inhibition by down regulation of GABAB receptors
70. Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats
71. Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat
72. Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties
73. Temporal and spatial patterns of DNA fragmentation following focally or systemically-evoked status epilepticus in rats
74. Status epilepticus-induced neuronal damage in the rat amygdaloid complex: Distribution, time-course and mechanisms
75. Irreversible neuronal damage after short periods of status epilepticus
76. Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus
77. In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat
78. Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures
79. Seizure related elevations of extracellular amino acids in human focal epilepsy
80. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
81. Excitatory amino acids as a final common pathway for neurologic disorders
82. Metabotropic glutamate receptor activation and blockade: Their role in long-term potentiation, learning and neurotoxicity
83. Roles of metabotropic glutamate receptors in LTP and LTD in hippocampus
84. 3H] glutamate-binding sites in rat brain
85. Excitotoxicity and NMDA receptor
86. Non-NMDA-receptor-mediated neurotoxicity in cortical culture
87. Neuronal apoptosis in acute necrotic insults: Why is this subject such a mess?
88. Excitotoxic cell death
89. The calcium ion and cell death
90. Apoptosis: A biological phenomenon with ranging implications in tissue kinetics
91. 2+ channel antagonists and neuroprotection from cerebral ischemia
92. Apoptosis in neurological disease
93. Seizure-induced neuronal necrosis: Implications for programmed cell death mechanisms
94. In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons
95. Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy
96. Progressive neuronal loss induced by kindling: A possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis
97. Neuronal loss induced in limbic pathways by kindling: Evidence for induction of hippocampal sclerosis
98. Do seizures cause neuronal damage in rat amygdala kindling?
99. Hippocampal kindling protects several structures from the neuronal damage resulting from kainic acid-induced status epilepticus
100. Limbic seizures without brain damage after injection of low doses of kainic acid into the amygdala of freely moving rats
101. Kindling-induced neurogenesis in the dentate gyrus of the rat
102. Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat
103. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat
104. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
105. Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures
106. Increased neurogenesis in a model of electroconvulsive therapy
107. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
108. Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat
109. Electroconvulsive therapy (ECT)-induced seizures as a model system for human epilepsy studied by SPECT difference imaging
110. SPECT ictal-interictal difference imaging reveals thalamic and brainstem reticular formation involvement in seizures
111. The pathological substrate of limbic epilepsy: Neuronal loss in the medial dorsal thalamic nucleus as the consistent change
112. The midline thalamus: Alterations and a potential role in limbic epilepsy
113. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus
114. Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy
115. Amygdala kindling and c-fos protein(s)
116. Regional expression of c-fos mRNA in rat brain during the evolution of amygdala-kindled seizures
117. Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats
118. Expression of c-fos mRNA in acute and kindled cocaine seizures in rats
119. Regional analysis of the spatial patterns of Fos induction in brain following flurothyl kindling
120. Amygdala kindling and immediate-early genes
121. Expression of the proto-oncogene c-fos following electrical kindling in the rat
122. Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy
123. In vivo administration of c-Fos antisense oligonucleotides accelerates amygdala kindling
124. Intra-amygdala infusion of an end-capped antisense oligodeoxynucleotide to c-fos accelerates amygdala kindling
125. Progression in mesial temporal lobe epilepsy
126. Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy
127. Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions
128. Hippocampal sclerosis studied in identical twins
129. Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis
130. Puberty in the rat
131. Partial (focal) seizures in developing brain
132. Resistance of the immature hippocampus to seizure-induced synaptic reorganization
133. Kainic-acid-induced seizures: A developmental study
134. Resistance of the immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling
135. Flurothyl status epilepticus in developing rats: Behavioral, electrographic, histological and electrophysiological studies
136. Patterns of status epilepticus-induced neuronal injury during development and long-term consequences
137. Serum neuron-specific enolase is a marker for neuronal damage following status epilepticus in the rat
138. Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling
139. Seizure-induced neuronal injury: Vulnerability to febrile seizures in an immature rat model
140. Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits
141. Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain
142. Recurrent status epilepticus in children
143. Risk of seizure recurrence following a first unprovoked seizure in childhood: A prospective study
144. Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment
145. Cortical malformations and epilepsy: New insights from animal models
146. Transplacentally induced neuronal migration disorders: An animal model for the study of the epilepsies
147. Neuronal migration disorders increase seizure susceptibility to febrile seizures
148. Molecular and experimental aspects of neuronal migration disorders
149. Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders
150. Granule cell neurogenesis after status epilepticus in the immature rat brain
151. Reduced neurogenesis after neonatal seizures
152. Resistance to damage of the immature hippocampus to flurothyl induced status epilepticus
153. Mossy fiber sprouting after recurrent seizures during early development in rats
154. Brain development and generation of brain pathologies
155. An immature mossy fiber innervation of hilar neurons may explain their resistance to kainate cell death in 15 day old rats
156. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
157. Febrile seizures lead to increased susceptibility to limbic seizures during adulthood
158. Vulnerability of CA1 neurons to glutamate is developmentally regulated
159. The ontogeny of excitatory amino acid receptors in the rat forebrain-II. Kainic acid receptors
160. Kainic acid seizure syndrome and binding sites in developing rats
161. The ontogeny of excitatory amino acid receptors in the rat forebrain-I. N-methyl-D-aspartate and quisqualate receptors
162. Transient increased density of NMDA binding sites in the developing rat hippocampus
163. (2+)-permeable kainate/AMPA receptors more abundant in immature brain?
164. Regional analysis of developmental changes in the extent of GluR6 mRNA editing in rat brain
165. Expression of the gene coding for NR1 subunit of the NMDA receptor during rat brain development
166. Development profile of metabotropic glutamate 3 receptor mRNA in rat brain
167. Developmental regulation of glutamate and GABAA receptor gene expression in rat hippocampus following kainate-induced status epilepticus
168. Peptide-induced infant status epilepticus causes neuronal death and synaptic organization
169. Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats
170. Idiosyncrasies of limbic kindling in developing rats
171. Infantile status epilepticus and future seizure susceptibility in the rat
172. Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood
173. Effects of kainic acid on seizure susceptibility in the developing brain
174. Long-term behavioral deficits following pilocarpine seizures in immature rats
175. Kindling and spatial cognition
176. Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acid
177. Is the amygdaloid neuron necessay for amygdaloid kindling?
178. Age-dependent cognitive and behavioral deficits after kainic acid seizures
179. A single neonatal pentylenetetrazol or hypothermia convulsion increases kindling susceptibility in the adult rat
180. Kindling in developing rats: Persistence of seizures into adulthood
181. Maturational changes in postictal refractoriness and seizure susceptibility in developing rats
182. Catamenial epilepsy: Clinical aspects
183. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: Correlation with dendritic spine density
184. Comparative effects of estradiol benzoate, the antiestrogen clomiphene citrate, and the progestin medroxyprogesterone acetate on kainic acid-induced seizures in male and female rats
185. Estrogen alters the acquisition of seizures kindled by repeated amygdala stimulation or pentylenetetrazol administration in ovariectomized female rats
186. Estradiol replacement to female rats facilitates dorsal hippocampal but not ventral hippocampal kindled seizure acquisition
187. Hormonal effects on the brain
188. Region-specific modulation of limbic seizure susceptibility by ovarian steroids
189. The effects of estrogen, progesterone, and ionized calcium on seizures during the menstrual cycle of epileptic women
190. Steroid hormone effects on picrotoxin-induced seizures in female and male rats
191. Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus
192. Estrogen protects primary cortical neurons from glutamate toxicity
193. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death
194. Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system
195. Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus
196. Neuropathological protection after traumatic brain injury in intact female rats versus males or ovariectomized females
197. Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat
198. Kindling
199. Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae
200. Kainate-induced status epilepticus alters glutamate and GABA-A receptor gene expression
201. Neuroprotective therapy
202. Modulation of glutamate receptor pathways in the search for new neuroprotective agents
203. +-channel down-modulation versus presynaptic glutamate release inhibition
204. Neuroprotective versus neurodestructive effects of NO-related species
205. Neuroprotective properties of statins in cerebral ischemia and stroke
206. Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors
207. Estrogens have neuroprotective effects on hippocampal cells in adult females following kainic acid-induced status epilepticus
208. Cellular and molecular basis of estrogen's neuroprotection. Potential relevance for Alzheimer's disease
209. Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus