Is type 2 diabetes mellitus a disorder of the brain?

Nutrition

Volumn 18, Issue 7-8, 2002, Pages 667-672

  Das, U N ^a  

^a EFA Sciences LLC   (United States)

Author keywords

Long chain polyunsaturated fatty acids; Type 2 diabetes mellitus

Indexed keywords

ACETYLCHOLINE; INSULIN; INSULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 2; LONG CHAIN FATTY ACID; NITRIC OXIDE; POLYUNSATURATED FATTY ACID; SOMATOMEDIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BRAIN DEVELOPMENT; BRAIN DISEASE; BRAIN GROWTH; ESSENTIAL FATTY ACID DEFICIENCY; HORMONE ACTION; HUMAN; NERVE CELL LESION; NON INSULIN DEPENDENT DIABETES MELLITUS; PREGNANCY; PRIORITY JOURNAL; PROTEIN FUNCTION; THIRD TRIMESTER PREGNANCY; ZONA INCERTA;

ACETYLCHOLINE; BRAIN CHEMISTRY; BRAIN DISEASES; CYTOKINES; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, UNSATURATED; HUMANS; HYPOTHALAMIC DISEASES; HYPOTHALAMUS, MIDDLE; INSULIN; NITRIC OXIDE; RECEPTOR, INSULIN; SOMATOMEDINS;

EID: 0036294980     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(02)00746-3     Document Type: Article

References (100)

1. The fetal origins of adult disease
2. The role of TNFalpha and TNF receptors in obesity and insulin resistance
3. Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease
4. GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus
5. Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction
6. Effect of prostaglandins and their precursors on the proliferation of human lymphocytes and their secretion of tumor necrosis factor and various interleukins
7. Effect of n-6 and n-3 fatty acids on the proliferation and secretion of TNF and IL-2 by human lymphocytes in vitro
8. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
9. The VMH-dietary obese rat: A new model of non-insulin dependent diabetes mellitus
10. Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats
11. Evidence of a physiological role for neuropeptide Y in ventromedial hypothalamic lesion-induced hyperphagia
12. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats
13. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats
14. Aspects of hypothalamic neuronal systems in VMH lesion-induced obese rats
15. Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats
16. The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats
17. Neuroimmunomodulatory actions of hypothalamic interferon-alpha
18. Effects of chronic stress on hypothalamic interleukin-1beta, interleukin-2, and gonadotrophin-releasing hormone gene expression in overiectomized rats
19. Differential effects of tumor necrosis factor-alpha and -beta on rat ventromedial hypothalamic neurons in vitro
20. A new concept in neurodegeneration: TNFalpha is a silencer of survival signals
21. A new mechanism of neurodegeneration: Proinflammatory cytokine inhibits receptor signaling by a survival peptide
22. Polyunsaturated fatty acids are potent neuroprotectors
23. A receptors to postsynaptic domains by insulin
24. Role of brain insulin receptor in control of body weight and reproduction
25. Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas
26. The brain-lipid-heart connection
27. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
28. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: A putative hypothalamic site for energy homeostasis
29. Effects of feeding and insulin on extracellular acetylcholine in the amygdala of freely moving rats
30. Involvement of cholinergic neurons in the release of dopamine elicited by stimulation of mu-opioid receptors in striatum
31. Brain dopamine and obesity
32. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
33. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants
34. Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex
35. Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes
36. Hippocampal acetylcholine release during memory testing in rats: Augmentation by glucose
37. Is obesity an inflammatory condition?
38. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats
39. Dopamine D-5 receptor modulates hippocampal acetylcholine release
40. Essential fatty acids: Biology and their clinical implications
41. Possible beneficial action(s) of glucose-insulin-potassium regimen in acute myocardial infarction and inflammatory conditions: A hypothesis
42. Is insulin an anti-inflammatory molecule?
43. Can glucose-insulin-potassium regimen suppress inflammatory bowel disease?
44. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: A specific vascular action of insulin
45. Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network
46. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: Role of glucose, insulin and macrophages
47. Endotoxin-induced acute lung injury in rats: Role of insulin
48. Inhaled nitric oxide prevents IL-1 induced neutrophil accumulation and associated acute edema in isolated rats lungs
49. Insulin-like growth factor 1 stimulates the release of acetylcholine from rat cortical slices
50. Acetylcholine stimulates the release of nitric oxide from rat spinal cord
51. The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids
52. Insulin resistance and hyperinsulinemia: Are they secondary to an alteration in the metabolism of essential fatty acids?
53. Effect of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites cells
54. Dose-dependent effect of dietary fish-oil (n-3) polyunsaturated fatty acids on in vivo insulin sensitivity in rat
55. Amelioration of insulin resistance and hypertension in a fructose-fed rat model with fish oil supplementation
56. Influence of highly purified eicosapentaenoic acid ethyl ester on insulin resistance in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous non-insulin dependent diabetes mellitus
57. Long-term administration of highly purified eicosapenatenoic acid ethyl ester prevents diabetes and abnormalities of blood coagulation in male WBN/Kob rats
58. Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity
59. The fatty acid composition of skeletal muscle membrane phospholipid: Its relationship with the type of feeding and plasma glucose levels in young children
60. Long-term effects of the intrauterine environment, birth weight and breast-feeding in Pima Indians
61. Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians
62. Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men
63. Relationship between plasma insulin and erythrocyte fatty acid composition
64. Long-term effects of fish oil on insulin resistance and plasma lipoproteins in NIDDM patients with hypertriglyceridemia
65. Early nutrition in preterm infants and later blood pressure: Two cohorts after randomized trials
66. Can perinatal supplementation of long chain polyunsaturated fatty acids prevent hypetension in adult life?
67. DHA status of preterm infants at birth and following feeding with human milk or formula
68. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoic accumulation than formula-fed infants not consuming dietary docosahexaenoate
69. Docosahexaenoic and arachidonic acid content of serum and red blood cell membrane phospholipids of preterm infants fed breast milk, standard formula or formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids
70. NF-kB in neuronal plasticity and neurodegenerative disorders
71. Perinatal omega-3 deficiency affects blood pressure later in life
72. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
73. Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-aceylethanolamines in piglets
74. Leptin-regulated endocannabinoids are involved in maintaining food intake
75. Reduction of leptin gene expression by dietary polyunsaturated fatty acids
76. Does breast-feeding protect against childhood obesity?
77. Milk and diabetes
78. Relation of infant feeding to adult serum cholesterol concentration and death from ischemic heart disease
79. Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids
80. Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus
81. Use of cod liver oil during pregnancy associated with lower risk of type 1 diabetes in the offspring
82. Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: But why and how?
83. Nutritional factors in the pathobiology of human essential hypertension
84. Oestrogen, statins and polyunsaturated fatty acids: Similarity in their actions ans benefits - Is there a common link?
85. Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus
86. Dietary fat content alters insulin-mediated glucose metabolism in healthy men
87. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
88. Diet and risk of type II diabetes: The role of types of fat and carbohydrate
89. Dietary fat intake and risk of type 2 diabetes in women
90. Pregnancy complications and maternal risk of ischaemic heart disease: A retrospective cohort study of 129 290 births
91. Birthweight, early environment, and genetics: A study of twins discordant for acute myocardial infarction
92. Birthweights, maternal cardiovascular events, and Barker hypothesis
93. Maternal low protein diet in rats programmes fatty acid desaturase activities in the offspring
94. Early and late effects of breast-feeding: Does breast-feeding really matter?
95. Prevention of alloxan-induced cytotoxicity and diabetes mellitus by γ-linolenic acid and other polyunsaturated fatty acids both in vitro and in vivo
96. Anti-biotic-like actions of essential fatty acids
97. Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet
98. Long chain polyunsaturated fatty acids (LC-PUFAs) and perinatal development
99. No-new-neurons dogma loses ground