SCOPUS 정보 검색 플랫폼

Current Medicinal Chemistry

Volumn 9, Issue 13, 2002, Pages 1229-1250

Thrombin receptor antagonists; recent advances in PAR-1 antagonist development

(2) Anderluh, M a Sollner Dolenc, M a

a UNIVERSITY OF LJUBLJANA (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

7 [[4 (1 METHYLETHYL)PHENYL]METHYL] 7H PYRROLO[3,2 F]QUINAZOLINE 1,3 DIAMINE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; ARGATROBAN; ARGININE; ASPARAGINASE; BENZIMIDAZOLE DERIVATIVE; FR 171113; HIRUDIN; HIRULOG; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; LEUCINE; METHYL 2 [3 (4 CHLOROPHENYL) 2 [(2,4 DICHLOROBENZOYL)IMINO] 4 OXO 1,3 THIAZOLIDIN 5 YLIDENE]ACETATE; N3 CYCLOPROPYL 7 [[4 (1 METHYLETHYL)PHENYL]METHYL] 7H PYRROLO[3,2 F]QUINAZOLINE 1,3 DIAMINE; PHENYLALANINE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 ANTAGONIST; QUINAZOLINE DERIVATIVE; RWJ 56110; RWJ 58259; SCH 203099; SCH 79797; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; THROMBIN RECEPTOR ANTAGONIST; THROMBOXANE A2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTICOAGULATION; ARTERY THROMBOSIS; ATHEROSCLEROSIS; BLEEDING; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART INFARCTION; HUMAN; HUMAN CELL; INFLAMMATION; NERVE DEGENERATION; RESTENOSIS; REVIEW; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION; THROMBOCYTE ACTIVATION; VASCULAR ENDOTHELIUM;

EID: 0036287538 PISSN: 09298673 EISSN: None Source Type: Journal
DOI: 10.2174/0929867023369934 Document Type: Review

Times cited : (26)

References (82)

1
- 0033289848
- King, F.D. and Oxford, A.W. Ed.; Elsevier Science B.V. Amsterdam
- (1999) Progress in Medicinal Chemistry , vol.36 , pp. 29-90
- Eldred, C.D.¹ Judkins, B.D.²

2
- 0032413117
- (1998) Hematol. Oncol. Clin. North. Am , vol.12 , pp. 1211
- Harker, L.A.¹

3
- 0009584729
- (1989) Ann. Rev. Physiol , vol.69 , pp. 60
- Siess, W.¹

4
- 0027460147
- (1992) Pharmacol. Res , vol.27 , pp. 1
- De Caterina, R.¹ Sicari, R.²

5
- 0030762060
- (1997) Thromb. Res , vol.87 , pp. 37
- Ray, A.¹ Hegde, L.G.² Gupta, J.B.³

6
- 0034161592
- (2000) Trends Pharmacol. Sci , vol.21 , pp. 103
- Cocks, T.M.¹ Moffatt, J.D.²

7
- 0030032791
- (1996) Biochem. J , vol.313 , pp. 353
- Grand, R.J.A.¹ Turnell, A.S.² Grabham, P.W.³

8
- 0028279039
- (1994) J. Exp. Med , vol.179 , pp. 1737
- Grandaliano, G.¹ Valente, A.J.² Abboud, H.E.³

9
- 0032087893
- (1998) Int. J. Biochem. Cell Biol , vol.30 , pp. 641
- Goldsack, N.R.¹ Chambers, R.C.² Dabbagh, K.³ Laurent, J.⁴

10
- 0029058731
- (1995) J. Eur. J. Med. Chem , vol.30 S , pp. 117
- Van Obberghen-Schilling, E.¹ Chambard, J.-C.² Vouret-Craviari, V.³ Chen, Y.-H.⁴ Grall, D.⁵ Pouysségur, J.⁶

11
- 0035019636
- (2001) Pharmacol. Rev , vol.53 , pp. 245
- Macfarlane, S.R.¹ Seatter, M.J.² Kanke, T.³ Hunter, G.D.⁴ Plevin, R.⁵

12
- 0035653828
- (2001) Curr. Opin. Pharmacol , vol.1 , pp. 575
- Schmidlin, F.¹ Bunnett, N.W.²

13
- 0020527401
- (1983) Biosci. Rep , vol.3 , pp. 255
- Gustafson, G.T.¹ Lerner, U.²

14
- 0026035523
- (1991) Cell , vol.64 , pp. 1057
- Vu, T.-K.H.¹ Hung, D.T.² Wheaton, V.I.³ Coughlin, S.R.⁴

15
- 0028225267
- (1994) Ann. Biol. Clin , vol.52 , pp. 257
- Lasne, D.¹ Rendu, F.² Aiach, M.³

16
- 37449011714
- (2000) Blood , vol.96 , pp. 2469
- Dörmann, D.¹ Clemetson, K.J.² Kehrel, B.E.³

17
- 0032871407
- (1999) Exp. Opin. Ther. Patents , vol.9 , pp. 1389
- Geiger, J.¹

18
- 0031029996
- (1997) J. Biol. Chem , vol.272 , pp. 1997
- Liu, L.¹ Freedman, J.² Hornstein, A.³ Fenton J.W. II⁴ Song, Y.⁵ Ofosu, F.⁶

19
- 0026577704
- (1992) J. Clin. Invest , vol.89 , pp. 351
- Coughlin, S.R.¹ Vu, T.-K.H.² Hung, D.T.³ Wheaton, V.I.⁴

20
- 0027933068
- (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9208
- Nystedt, S.¹ Emilsson, K.² Wahlestedt, C.³ Sundelin, J.⁴

21
- 0030979972
- (1997) Nature , vol.386 , pp. 502
- Ishiara, H.¹ Connolly, A.J.² Zeng, D.³ Kahn, M.L.⁴ Zheng, Y.W.⁵ Timmons, C.⁶ Tram, T.⁷ Coughlin, S.R.⁸

22
- 0032499696
- (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6642
- Xu, W.-F.¹ Andersen, H.² Whitmore, T.E.³ Presnell, S.R.⁴ Yee, D.P.⁵ Ching, A.⁶ Gilbert, T.⁷ Davie, E.W.⁸ Foster, D.C.⁹

23
- 0031919771
- (1998) Can. J. Physiol. Pharmacol , vol.76 , pp. 16
- Cheung, W.-M.¹ Andrade-Gordon, P.² Derian, C.K.³ Damiano, B.P.⁴

24
- 0035864391
- (2001) Archives Biochem. Biophys , vol.386 , pp. 195
- Maryanoff, B.E.¹ Santulli, R.² McComsey, D.F.³ Hoekstra, W.J.⁴ Hoey, K.⁵ Smith, C.E.⁶ Addo, M.⁷ Darrow, A.L.⁸ Andrade-Gordon, P.⁹

25
- 0009585016
- JAI Press Inc. Bittar, E.E. and Lapetina E.G. Ed.: London
- (1997) Advances in Molecular and Cell Biology , vol.18 , pp. 129-143
- Coughlin, S.R.¹

26
- 0027309290
- (1993) J. Biol. Chem , vol.268 , pp. 9780
- Ishii, K.¹ Hein, L.² Kobilka, B.³ Coughlin, S.R.⁴

27
- 0028009801
- (1994) J. Biol. Chem , vol.269 , pp. 1125
- Ishii, K.¹ Chen, J.² Ishii, M.³ Koch, W.J.⁴ Freedman, N.J.⁵ Lefkowitz, R.J.⁶ Coughlin, S.R.⁷

28
- 0027378281
- (1993) J. Biol. Chem , vol.268 , pp. 13756
- Hoxie, J.A.¹ Ahuja, M.² Belmonte, E.³ Pizarro, S.⁴ Parton, R.⁵ Brass, L.F.⁶

29
- 0031041906
- (1997) J. Biol. Chem , vol.272 , pp. 6011
- Molino, M.¹ Bainton, D.F.² Hoxie, J.A.³ Coughlin, S.R.⁴ Brass, L.F.⁵

30
- 0026775223
- (1992) J. Biol. Chem , vol.267 , pp. 6081
- Vassallo R.R., Jr.¹ Kieber-Emmons, T.² Cichowski, K.³ Brass, L.F.⁴

31
- 0034306566
- (2000) Thromb. Res , vol.100 , pp. 89
- Pakala, R.¹ Liang, C.T.² Benedict, C.R.³

32
- 0033056289
- 1450
- (1999) Biochim. Biophys. Acta , pp. 265
- Cichowski, K.¹ Orsini, M.J.² Brass, L.F.³

33
- 0029977763
- (1996) Semin. Thromb. Hemostas , vol.22 , pp. 223
- Seiler, S.M.¹

34
- 0027205029
- (1993) J. Biol. Chem , vol.268 , pp. 14322
- Rasmussen, U.B.¹ Gachet, C.² Schlesinger, Y.³ Hanau, D.⁴ Ohlmann, P.⁵ Van Obberghen-Schilling, E.⁶ Pouysségur, J.⁷ Cazenave, J.P.⁸ Pavirani, A.⁹

35
- 0027533213
- (1993) J. Biol. Chem , vol.268 , pp. 421
- Bartha, K.¹ Brisson, C.² Archinpoff, G.³ De la Salle, C.⁴ Lanza, F.⁵ Cazenave, J.P.⁶ Beretz, A.⁷

36
- 4244127213
- (1992) Circulation , vol.86
- Ewenstein, B.M.¹ Birch, K.A.² Gamberdella, M.³ Ritchie, A.J.⁴ Zavoico, G.B.⁵

37
- 34250074872
- (1993) Persp. Drug Discovery Des , vol.1 , pp. 527
- Ogletree, M.L.¹ Natarajan, S.² Seiler, S.M.³

38
- 0025784847
- (1991) FEBS Lett , vol.288 , pp. 123
- Rasmussen, U.B.¹ Vouret-Craviari, V.² Jallat, S.³ Schlesinger, Y.⁴ Pagés, G.⁵ Pavirani, A.⁶ Lecocq, J.-P.⁷ Pouysségur, J.⁸ Van Obberghen-Schilling, E.⁹

39
- 0027275314
- (1993) J. Cell Physiol , vol.156 , pp. 541
- Garcia, J.G.¹ Patterson, C.² Bahler, C.³ Aschner, J.⁴ Hart, C.M.⁵ English, D.⁶

40
- 0034967927
- (2001) J. Pharmacol. Exp. Ther , vol.298 , pp. 34
- Andrade-Gordon, P.¹ Derian, C.K.² Maryanoff, B.E.³ Zhang, H.-C.⁴ Addo, M.F.⁵ Cheung, W.-M.⁶ Damiano, B.P.⁷ D'Andrea, M.R.⁸ Darrow, A.L.⁹ De Garavilla, L.¹⁰ Eckardt, A.J.¹¹ Giardino, E.C.¹² Haertlein, B.J.¹³ McComsey, D.F.¹⁴

41
- 0030478939
- (1996) J. Biol. Chem , vol.271 , pp. 32874
- Shapiro, M.J.¹ Trejo, J.² Zeng, D.³ Coughlin, S.R.⁴

42
- 0033545627
- (1999) Nature , vol.398 , pp. 156
- Cocks, T.M.¹ Fong, B.² Chow, J.M.³ Anderson, G.P.⁴ Frauman, A.G.⁵ Goldie, R.G.⁶ Henry, P.J.⁷ Carr, M.J.⁸ Hamilton, J.R.⁹ Moffatt, J.D.¹⁰

43
- 0027232790
- (1993) J. Immunol , vol.150 , pp. 4876
- Tordai, A.¹ Fenton J.W. II² Anderson, T.³ Gelfand, E.W.⁴

44
- 0027409288
- (1993) Biochem. J , vol.290 , pp. 571
- Joseph, S.¹ MacDermot, J.²

45
- 0031004161
- (1997) Eur. J. Pharmacol , vol.323 , pp. 111
- Debeir, T.¹ Vigé, X.² Benavides, J.³

46
- 0026519282
- (1992) Neuron , vol.8 , pp. 363
- Suidan, H.S.¹ Stone, S.R.² Hemmings, B.A.³ Monard, D.⁴

47
- 0029057398
- (1995) Circulation , vol.91 , pp. 2961
- Cook, J.J.¹ Sitko, G.R.² Bednar, B.³ Condra, C.⁴ Mellott, M.J.⁵ Feng, D.-M.⁶ Nutt, R.M.⁷ Shafer, J.A.⁸ Gould, R.J.⁹ Connolly, T.M.¹⁰

48
- 0029095342
- (1995) Clin. Immunol. Immunopathol , vol.76 , pp. 225
- Shin, H.¹ Nakajima, T.² Kitajima, I.³ Shigeta, K.⁴ Abeyama, K.⁵ Imamura, T.⁶ Okano, T.⁷ Kawahara, K.⁸ Nakamura, T.⁹ Maruyama, I.¹⁰

49
- 0033028896
- (1999) Ann. Rheum. Dis , vol.58 , pp. 55
- Shin, K.¹ Kitajima, I.² Nakajima, T.³ Shao, Q.⁴ Tokioka, T.⁵ Takasaki, I.⁶ Hanyu, N.⁷ Kubo, T.⁸ Maruyama, I.⁹

50
- 0028783378
- (1995) J. Med. Chem , vol.38 , pp. 4125
- Feng, D.-M.¹ Veber, D.F.² Connoly, T.M.³ Condra, C.⁴ Tang, M.-J.⁵ Nutt, R.F.⁶

51
- 0026629249
- (1992) J. Biol. Chem , vol.267 , pp. 13146
- Scarborough, R.M.¹ Naughton, M.A.² Teng, W.³ Hung, D.T.⁴ Rose, J.⁵ Vu, T.-K.H.⁶ Wheaton, V.I.⁷ Turck, C.W.⁸ Coughlin, S.R.⁹

52
- 0026718781
- (1992) Biochem. Biophys. Res. Comm , vol.184 , pp. 790
- Hui, K.Y.¹ Jakubowski, J.A.² Wyss, V.L.³ Angelton, E.L.⁴

53
- 0028808617
- (1995) Bioorg. Med. Chem. Lett , vol.5 , pp. 2417
- Shimamoto, T.¹ Tsuboi, H.² Kitajima, Y.³ Miyazaki, T.⁴ Oyama, Y.⁵ Imajo, S.⁶ Ishiguro, M.⁷

54
- 0033490425
- (1999) Bioorg. Med. Chem , vol.7 , pp. 2353
- Ceruso, M.A.¹ McComsey, D.F.² Leo, G.C.³ Andrade-Gordon, P.⁴ Addo, M.F.⁵ Scarborough, R.M.⁶ Oksenberg, D.⁷ Maryanoff, B.E.⁸

55
- 0029816605
- (1996) J. Med. Chem , vol.39 , pp. 3585
- Matsoukas, J.M.¹ Panagiotopoulos, D.² Keramida, M.³ Mavromoustakos, T.⁴ Yamdagni, R.⁵ Wu, Q.⁶ Moore, G.J.⁷ Saiffeddine, M.⁸ Hollenberg, M.D.⁹

56
- 0035254536
- (2001) J. Med. Chem , vol.44 , pp. 328
- Alexopoulos, K.¹ Panagiotopoulos, D.² Mavromoustakos, T.³ Fatseas, P.⁴ Paredes-Carbajal, M.C.⁵ Mascher, D.⁶ Mihailescu, S.⁷ Matsoukas, J.⁸

57
- 0029758276
- (1996) J. Med. Chem , vol.39 , pp. 4879
- Bernatowicz, M.S.¹ Klimas, C.E.² Hartl, K.S.³ Peluso, M.⁴ Allegretto, N.J.⁵ Seiler, S.M.⁶

58
- 0021779081
- (1985) Adv. Protein Chem , vol.37 , pp. 1
- Rose, G.D.¹ Gierasch, L.M.² Smith, J.A.³

59
- 0033579981
- (1999) Bioorg. Med. Chem. Lett , vol.9 , pp. 255
- McComsey, D.F.¹ Hecker, L.R.² Andrade-Gordon, P.³ Addo, M.F.⁴ Maryanoff, B.E.⁵

60
- 0030023688
- (1996) Mol. Pharmacol , vol.49 , pp. 190
- Seiler, S.M.¹ Peluso, M.² Tuttle, J.G.³ Pryor, K.⁴ Klimas, C.⁵ Matsueda, G.R.⁶ Bernatowicz, M.S.⁷

61
- 0027325620
- (1993) Biochem. Biophys. Res. Commun , vol.193 , pp. 694
- Nose, T.¹ Shimogashi, Y.² Ohno, M.³ Costa, T.⁴ Shimizu, N.⁵ Ogino, Y.⁶

62
- 0028919211
- (1995) Int. J. Pept. Protein Res , vol.45 , pp. 145
- Natarajan, S.¹ Reixinger, D.² Peluso, M.³ Seiler, S.⁴

63
- 0033577762
- (1999) Bioorg. Med. Chem. Lett , vol.9 , pp. 1423
- McComsey, D.F.¹ Hawkins, M.J.² Andrade-Gordon, P.³ Addo, M.F.⁴ Oksenberg, D.⁵ Maryanoff, B.E.⁶

64
- 0002522895
- (1992) Circulation , vol.86 , pp. 1-151
- Scarborough, R.M.¹ Teng, W.² Naughton, M.A.³ Rose, J.W.⁴ Alves, V.⁵ Arfsten, A.⁶

65
- 0028061845
- (1994) Am. J. Physiol , vol.267
- Tesfamariam, B.¹

66
- 0028850759
- (1995) Biochem. Pharmacol , vol.49 , pp. 519
- Seiler, S.M.¹ Peluso, M.² Michel, I.M.³ Goldenberg, H.⁴ Fenton J.W. II⁵ Reixinger, D.⁶ Natarajan, S.⁷

67
- 0032855356
- (1999) J. Biochem. Tokyo , vol.126 , pp. 174
- Fujita, T.¹ Nose, T.² Nakajima, M.³ Inoue, Y.⁴ Costa, T.⁵ Shimohigashi, Y.⁶

68
- 0033577727
- (1999) Bioorg. Med. Chem. Lett , vol.9 , pp. 1351
- Fujita, T.¹ Nakajima, M.² Inoue, Y.³ Nose, T.⁴ Shimohigashi, Y.⁵

69
- 0032493407
- (1998) Bioorg. Med. Chem. Lett , vol.8 , pp. 1649
- Hoekstra, W.J.¹ Hulshizer, B.L.² McComsey, D.F.³ Andrade-Gordon, P.⁴ Kauffman, J.A.⁵ Addo, M.F.⁶ Oksenberg, D.⁷ Scarborough, R.M.⁸ Maryanoff, B.E.⁹

70
- 0030823980
- (1997) Can. J. Physiol. Pharmacol , vol.75 , pp. 832
- Hollenberg, M.D.¹ Saifeddine, M.² Al-Ani, B.³ Kawabata, A.⁴

71
- 0032911415
- (1999) J. Pharmacol. Exp. Ther , vol.288 , pp. 358
- Kawabata, A.¹ Saifeddine, M.² Al-Ani, B.³ Leblond, L.⁴ Hollenberg, M.D.⁵

72
- 13044257730
- (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12257
- Andrade-Gordon, P.¹ Maryanoff, B.E.² Derian, C.K.³ Zhang, H.-C.⁴ Addo, M.F.⁵ Darrow, A.L.⁶ Eckardt, A.J.⁷ Hoekstra, W.J.⁸ McComsey, D.F.⁹ Oksenberg, D.¹⁰ Reynolds, E.E.¹¹ Santulli, R.J.¹² Scarborough, R.M.¹³ Smith, C.E.¹⁴ White, K.B.¹⁵

73
- 0035966876
- (2001) J. Med. Chem , vol.44 , pp. 1021
- Zhang, H.-C.¹ Derian, C.K.² Andrade-Gordon, P.³ Hoekstra, W.J.⁴ McComsey, D.F.⁵ White, K.B.⁶ Poulter, B.L.⁷ Addo, M.F.⁸ Cheung, W.-M.⁹ Damiano, B.P.¹⁰ Oksenberg, D.¹¹ Reynolds, E.E.¹² Pandey, A.¹³ Scarborough, R.M.¹⁴ Maryanoff, B.E.¹⁵

74
- 0035921058
- (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 2105
- Zhang, H.-C.¹ McComsey, D.F.² White, K.B.³ Addo, M.F.⁴ Andrade-Gordon, P.⁵ Derian, C.K.⁶ Oksenberg, D.⁷ Maryanoff, B.E.⁸

75
- 0033584185
- (1999) Bioorg. Med. Chem. Lett , vol.9 , pp. 2073
- Ahn, H.-S.¹ Arik, L.² Boykow, G.³ Burnett, D.A.⁴ Caplen, M.A.⁵ Czarniecki, M.⁶ Domalski, M.S.⁷ Foster, C.⁸ Manna, M.⁹ Stamford, A.W.¹⁰ Wu, Y.¹¹

76
- 0034670162
- (2000) Biochem. Pharmacol , vol.60 , pp. 1425
- Ahn, H.-S.¹ Foster, C.² Boykow, G.³ Stamford, A.⁴ Manna, M.⁵ Graziano, M.⁶

77
- 0035814038
- (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 2851
- Chackalamannil, S.¹ Doller, D.² Eagen, K.³ Czarniecki, M.⁴ Ahn, H.-S.⁵ Foster, C.J.⁶ Boykow, G.⁷

78
- 0033404539
- (1999) Eu. J. Pharmacol , vol.384 , pp. 197
- Kato, Y.¹ Kita, Y.² Nishio, M.³ Hirasawa, Y.⁴ Ito, K.⁵ Yamanaka, T.⁶ Motoyama, Y.⁷ Seki, J.⁸

79
- 0035935206
- (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 2691
- Barrow, J.C.¹ Nantermet, P.G.² Selnick, H.G.³ Glass, K.L.⁴ Ngo, P.L.⁵ Young, M.B.⁶ Pellicore, J.M.⁷ Breslin, M.J.⁸ Hutchinson, J.H.⁹ Freidinger, R.M.¹⁰ Condra, C.¹¹ Karczewski, J.¹² Bednar, R.A.¹³ Gaul, S.L.¹⁴ Stern, A.¹⁵ Gould, R.¹⁶ Connolly, T.M.¹⁷

80
- 18244372993
- (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 319
- Nantermet, P.G.¹ Barrow, J.C.² Lundell, G.F.³ Pellicore, J.M.⁴ Rittle, K.E.⁵ Young, M.B.⁶ Freidinger, R.M.⁷ Connolly, T.M.⁸ Condra, C.⁹ Karczewski, J.¹⁰ Bednar, R.A.¹¹ Gaul, S.L.¹² Gould, R.¹³ Predergast, K.¹⁴ Selnick, H.G.¹⁵

81
- 0034599753
- (2000) Bioorg. Med. Chem. Lett , vol.10 , pp. 661
- Stead, P.¹ Hiscox, S.² Robinson, P.S.³ Pike, N.B.⁴ Sidebottom, P.J.⁵ Roberts, A.D.⁶ Taylor, N.L.⁷ Wright, A.E.⁸ Pomponi, S.A.⁹ Langley, D.¹⁰

82
- 0028226451
- (1994) Trends Cardiovasc. Med , vol.4 , pp. 77
- Coughlin, S.R.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.