A novel molecular design of thrombin receptor antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 10, 1999, Pages 1351-1356

  Fujita, Tsugumi ^a   Nakajima, Masahide ^b   Inoue, Yoshihisa ^b   Nose, Takeru ^a   Shimohigashi, Yasuyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Green Cross Company   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 MERCAPTOPROPIONIC ACID; THROMBIN RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; LIGAND BINDING; PROTEIN CONFORMATION; THROMBOCYTE AGGREGATION;

ANTITHROMBINS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ELECTROSTATICS; HUMANS; LYSINE; MODELS, MOLECULAR; PLATELET AGGREGATION INHIBITORS; RECEPTORS, THROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033577727     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00202-4     Document Type: Article

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19. 2 (All other peptides were also shown in a similar way); Xaa, acidic amino acids such as Asp, Glu, and Aad.