Hepatic stellate cells: Role in microcirculation and pathophysiology of portal hypertension

Gut

Volumn 50, Issue 4, 2002, Pages 571-581

  Reynaert, Hendrik ^a   Thompson, M G ^b   Thomas, T ^b   Geerts, A ^a,b  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP; MYOSIN LIGHT CHAIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; RHO FACTOR; VASOACTIVE AGENT;

CHRONIC LIVER DISEASE; LIVER CELL; LIVER FIBROSIS; LIVER SINUSOID; MICROCIRCULATION; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; PRIORITY JOURNAL; REVIEW; STELLATE CELL;

CELL COMMUNICATION; HEPATOCYTES; HUMANS; HYPERTENSION, PORTAL; LIVER CIRCULATION; MICROCIRCULATION; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; VASOCONSTRICTOR AGENTS;

EID: 0036284634     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.50.4.571     Document Type: Review

References (149)

1. Pathophysiology of portal hypertension
2. Reduction of the increased portal vascular resistance of the isolated perfused rat liver by vasodilators
3. Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver
4. The stellate cell of the liver
5. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients
6. Hepatic stellate (ITO) cells: Expanding roles for a liver-specific pericyte
7. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
8. Morphologic investigation of sinusoidal cells
9. Immunocytochemical study on the liver innervation in patients with cirrhosis
10. History, heterogeneity, developmental biology and functions of quiescent hepatic stellate cells
11. Morphological mechanisms for regulating blood flow through hepatic sinusoids
12. The portal lobule in rat liver fibrosis: A re-evaluation of the liver unit
13. Direct measurements of blood pressures in minute vessels of the liver
14. Endothelin-1 induces direct constriction of hepatic sinusoids
15. Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver
16. Vasoactive effect of endothelin-1 on rat liver in vivo
17. ET-1 induced alterations of hepatic microcirculation: Sinusoidal and extrasinusoidal sites of action
18. Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver
19. Regulation of sinusoidal perfusion: In vivo methodology and control by endothelins
20. The heme oxygenase-carbon monoxide system: A regulator of hepatobillary function
21. Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation
22. Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver
23. Endothelin-1-induced vasoconstriction causes a significant increase in portal pressure of rat liver: Localized constrictive effect on distal segment of preterminal portal venules as revealed by light and electron microscopy and serial reconstruction
24. Morphological mechanisms for regulating blood flow through hepatic sinusoids
25. Relaxing effect of interleukin-1 on rat cultured Ito cells
26. Ito cell contraction in response to endothelin-1 and substance P
27. Activation of rat hepatic stellate cells in culture is associated with increased sensitivity to endothelin 1
28. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo
29. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: Implications for regulation of portal pressure and resistance
30. Liver microvascular architecture: An insight into the pathophysiology of portal hypertension
31. Ca(2+)-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction
32. Thin-filament linked regulation of smooth muscle myosin
33. Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction
34. Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells
35. Live dynamics of GFP-calponin: Isoform-specific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences
36. A role for serine-175 in modulating the molecular conformation of calponin
37. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
38. RhoA/rho-associated kinase mediates fibroblast contractile force generation
39. 2+ and rho signaling pathways: Two paths to hepatic stellate cell contraction
40. Inositol trisphosphate and diacylglycerol: Two interacting second messengers
41. Biological effects of C-type natriuretic peptide in human myofibroblastic stellate cells
42. In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels
43. Signal transduction and regulation in smooth muscle
44. Contraction of human hepatic stellate cells activated in culture: A role for voltage-operated calcium channels
45. Protein kinase C in the regulation of smooth muscle contraction
46. Plasma membrane calcium flux, protein kinase C activation and smooth muscle contraction
47. Phorbol ester-induced contraction in chemically skinned vascular smooth muscle
48. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus
49. Phospholipase D: Molecurar and cell biology of a novel gene family
50. Stimulation of actin stress fibre formation mediated by activation of phospholipase D
51. Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts
52. Association of phospholipase D activity with the detergent-insoluble cytoskeleton of U937 promonocytic leukocytes
53. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
54. The role of Rho in G protein-coupled receptor signal transduction
55. The small GTP-binding protein tho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
56. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
57. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
58. Regulation and functions of Rho-associated kinase
59. Lysophosphatidic acid enhances collagen gel contraction by hepatic stellate cells: Association with rho-kinase
60. ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1
61. Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton
62. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
63. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells
64. 2+ mobilization, and the actin cytoskeleton
65. Differential involvement of Galpha 12 and Galpha 13 in receptor-mediated stress fiber formation
66. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
67. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
68. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
69. Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3′: 5′-monophosphate-dependent protein kinase
70. Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex
71. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
72. The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes
73. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
74. The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo
75. Molecular characterization of endothelin receptors
76. Endothelin-1 induces vasoconstriction and nitric oxide release via endothelin ET(B) receptors in isolated perfused rat liver
77. Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1
78. Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver
79. 2+ oscillations, and activation of glycogenolysis
80. Enhanced synthesis and reduced metabolism of endothelin-1 (ET-1) by hepatocytes - An important mechanism of increased endogenous levels of ET-1 in liver cirrhosis
81. Enhanced expression of endothelin receptor subtypes n cirrhotic rat liver
82. Gene expression of endothelin-1 and ET(A) and ET(B) receptors in human cirrhosis: Relationship with hepatic hemodynamics
83. Endothelin-1 and -3 plasma concentrations in patients with cirrhosis: Role of splanchnic and renal passage and liver function
84. Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome
85. Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis
86. Circulating levels of endothelin in cirrhosis
87. Elevated circulating plasma endothelin-1 concentrations in cirrhosis
88. Clinical significance of plasma endothelin-1 in patients with chronic liver disease
89. Endothelin-1 and endothelin-3 in cirrhosis: Relations to systemic and splanchnic haemodynamics
90. Increased plasma endothelin in cirrhosis. Relationship with systemic endotoxemia and response to changes in effective blood volume
91. Plasma endothelin levels in patients with cirrhosis and their relationships to the severity of cirrhosis and renal function
92. Changes in plasma endothelin-1 and Big endothelin-1 induced by transjugular intrahepatic portosystemic shunts in patients with cirrhosis and refractory ascites
93. Plasma endothelin-1 and -3 in cirrhosis: Relationship with systemic hemodynamics, renal function and neurohumoral systems
94. Production and release of endothelin-1 from the gut and spleen in portal hypertension due to cirrhosis
95. Sinusoidal endothelial liver cells in vitro release endothelin: Augmentation by transforming growth factor β and Kupffer cell-conditioned media
96. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells
97. Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells
98. Regulation of endothelin-1 synthesis by endothelin-converting enzyme-1 during wound healing
99. Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway
100. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors
101. Endothelin, a potent peptide agonist in the liver
102. Beneficial hemodynamic effects of bosentan, a mixed ET(A) and ET(B) receptor antagonist, in portal hypertensive rats
103. The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver
104. Mixed endothelin receptor antagonist, SB209670, decreases portal pressure in biliary cirrhotic rats in vivo by reducing portal venous system resistance
105. Chronic blockade of endothelin receptors in cirrhotic rats: Hepatic and hemodynamic effects
106. The L-arginine-nitric oxide pathway
107. Nitric oxide and portal hypertension: Its role in the regulation of intrahepatic and splanchnic vascular resistance
108. The nitric oxide synthetase family of proteins
109. Nitric oxide modulates hepatic vascular tone in normal rat liver
110. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids
111. Regulation of endothelin-1 action on the perfused rat liver
112. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculatior, of cirrhotic rats
113. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension
114. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
115. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility
116. Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis
117. Prolonged antagonism of adrenergic vasoconstriction in the rat liver by atrial natriuretic peptide
118. Atrial natriuretic peptide antaginizes endothelin-induced calcium increase and cell contraction in cultured human hepatic stellate cells
119. Increased adrenomedullin levels in cirrhosis: Relationship with hemodynamic abnormalities and vasoconstrictor systems
120. Circulating adrenomedullin in cirrhosis: Relationship to hyperdynamic circulation
121. Human hepatic stellate cells secrete adrenomedullin: Potential autocrine factor in the regulation of cell contractility
122. Effect of adrenomedullin on hepatic pericytes (stellate cells) of the rat
123. Shear stress augments expression of C-type natriuretic peptide and adrenomedullin
124. Octreotide potentiates PKC-dependent vasoconstrictors in portal-hypertensive and control rats
125. Somatostatin suppresses endothelin-1 induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1
126. Inhibition of hepatic stellate cell contraction during activation in vitro by vascular endothelial growth factor in association with upregulation of FLT tyrosine kinase receptor family, FLT-1
127. Eicosanoid-mediated contractility of hepatic stellate cells
128. Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production
129. Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis
130. Arginine vasopressin induces contraction and stimulates growth of cultured human hepatic stellate cells
131. Hepatic hemodynamics and the renin-angiotensin system in cirrhosis
132. Biological functions of angiotensin and its receptors
133. Angiotensin II induces contraction and proliferation of human hepatic stellate cells
134. Plasma levels of substance P in liver cirrhosis: Relationship to the activation of vasopressor systems and urinary sodium excretion
135. Hyperdynamic circulation of cirrhotic rats: Role of substance P and its relationship to nitric oxide
136. Nucleotide receptors in hepatic stellate cells of the rat
137. Quantitation of rat hepatic stellate cell contraction: Stellate cells' contribution to sinusoidal resistance
138. Mechanisms and therapy of hepatic fibrosis: Report of the AASLD Single Topic Basic Research Conference
139. Type A, but not type B, endothelin receptor antagonists significantly decrease portal pressure in portal hypertensive rats
140. An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis
141. Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells
142. Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension
143. Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis
144. Randomized comparison of long-term losartan versus propranolol in lowering prortal pressure in cirrhosis
145. A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth
146. Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeleton
147. Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats
148. Effect of somastatin-14 on extracellular matrix expression by activated rat hepatic stellate cells