Plasma endothelin-1 and -3 in cirrhosis: Relationship with systemic hemodynamics, renal function and neurohumoral systems

Journal of Hepatology

Volumn 24, Issue 2, 1996, Pages 161-168

  Bernardi, Mauro ^a,b   Gülberg, Veit ^c   Colantoni, Alessandra ^c   Trevisani, Franco ^c   Gasbarrini, Antonio ^c   Gerbes, Alexander L ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c NONE

Author keywords

Cirrhosis; Endothelin 1; Endothelin 3; Hemodynamics; Posture; Renal function

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN 3; RENIN; SODIUM;

ADULT; AGED; ARTICLE; BODY POSTURE; CLINICAL ARTICLE; CONTROLLED STUDY; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; HUMAN; KIDNEY FUNCTION; LIVER CIRRHOSIS; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0342468273     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80025-0     Document Type: Article

References (45)

1. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375-411.
2. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, Masaki T. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separated genes. Proc Natl Acad Sci 1989; 86: 2863-7.
3. Haynes WG, Webb DJ. The endothelin family of peptides: local hormones with diverse roles in health and disease? Clin Sci 1993; 84: 485-500.
4. Rubanyi GM, Parker Bothelo LH. Endothelins. FASEB J 1991; 5: 2713-20.
5. Masaki T. The discovery, the present state, and the future prospects of endothelin. J Cardiovasc Pharmacol 1989; 13 (suppl 5): S1-S5.
6. Fukuda N, Soma M, Izumi Y, Minato M, Wanatabe Y, Wanatabe M, Hatano M. Low doses of endothelin-3 elicit endothelium dependent vasodilation which accompanies elevation of cyclic GMP. Jpn Circ J 1991; 55: 617-22.
7. Lippton HL, Cohen GA, McMurtry IF, Hyman AL. Pulmonary vasodilation to endothelin isopeptides is mediated by potassium channel activation. J Appl Physiol 1991; 70: 947-52.
8. Nakamoto H, Suzuki H, Murakami M, Kageyama Y, Naitoh M, Sakamaki Y, Ohishi A, Saruta T. Different effects of low and high dose of endothelin in the normotensive conscious dog. J Hypertension 1991; 9: 337-44.
9. Yamashita Y, Yukimura T, Miura K, Okumura M, Yamamoto K. Effects of endothelin-3 on renal function. J Pharmacol Exp Ther 1991; 259: 1256-60.
10. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodes J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988; 8: 1151-8.
11. Veglio F, Pinna G, Melchio R, Rabbia F, Panarelli M, Gagliardi B, Chiandussi L. Plasma endothelin levels in cirrhotic subjects. J Hepatol 1992; 15: 85-7.
12. Uchihara M, Izumi N, Sato C, Marumo F. Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis. Hepatology 1992; 16: 95-9.
13. Gülberg V, Gerbes AL, Vollmar AM, Paumgartner G. Endothelin-3 like immunoreactivity in plasma of patients with cirrhosis of the liver. Life Sci 1992; 51: 1165-9.
14. Moore K, Wendon J, Frazer M, Karani J, Williams R, Badr K. Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome. N Eng J Med 1992; 327: 1774-8.
15. Asbert M, Ginès A, Ginès P, Jimenez W, Clària J, Salò J, Arroyo V, Rivera F, Rodès J. Circulating levels of endothelin in cirrhosis. Gastroenterology 1993; 104: 1485-91.
16. Møller S, Emmeluth C, Henriksen JH. Elevated circulating plasma endothelin-1 concentrations in cirrhosis. J Hepatol 1993; 19: 285-90.
17. Salò J, Francitorra A, Follo A, Navasa M, Ginès A, Jimenez W, Ginès P, Arroyo V, Rivera F, Rodès J. Increased endothelin in cirrhosis. Relationship with systemic endotoxemia and response to changes in effective blood volume. J Hepatol 1995; 22: 389-98.
18. Bernardi M, Di Marco C, Trevisani F, De Collibus C, Fornalè L, Baraldini M, Andreone P, Cursaro C, Zacà F, Ligabue A, Gasbarrini G. The hemodynamic status of pre-ascitic cirrhosis: an evaluation under steady state condition and after postural change. Hepatology 1992; 16: 341-6.
19. Bernardi M, Di Marco C, Trevisani F, Fornalè F, Andreone P, Cursaro C, Baraldimi M, Ligabue A, Tame MR, Gasbarrini G. Renal sodium retention during upright posture in pre-ascitic cirrhosis. Gastroenterology 1993; 105: 188-93.
20. Bernardi M, Fornalè L, Di Marco C, Trevisani F, Baraldini M, Gasbarrini A, De Collibus C, Zacà F, Ligabue A, Colantoni A, Gasbarrini G. Hyperdynamic circulation of advanced cirrhosis: a re-appraisal based on posture-induced changes in hemodynamics. J Hepatol 1995; 22: 309-18.
21. Bernardi M, Trevisani F, Fornalè L, Di Marco C, Gasbarrini A, Baraldini M, Ligabue A, Gasbarrini G. Renal sodium handling in cirrhosis with ascites: mechanisms of impaired natriuretic response to reclining. J Hepatol 1994; 21: 1116-22.
22. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MR, Williams R. Transection of the esophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-9.
23. Trevisani F, Bernardi M, Gasbarrini A, Andreone P, Baraldini M, Cursaro C, Ligabue A, Tame MR, Giancane S, Gasbarrini G. Bed-rest induced hypernatriuresis in cirrhotic patients without ascites: does it contribute to maintain 'compensation'? J Hepatol 1992; 16: 190-6.
24. Bernardi M, De Palma R, Trevisani F, Malatesta R, Baraldini M, Cursaro C, Gasbarrini G. Unaltered dopaminergic modulation of aldosterone secretion in cirrhosis. Clin Sci 1988; 74: 137-43.
25. Bernardi M, Trevisani F, Santini C, Zoli G, Baraldini M, Ligabue A, Gasbarrini G. Plasma norepinephrine, weak neurotransmitters, and renin activity during active tilting in liver cirrhosis: relationship with cardiovascular homeostasis and renal function. Hepatology 1983; 3: 56-64.
26. Trevisani F, Bernardi M, De Palma R, Pancione L, Capani F, Baraldini M, Ligabue A, Gasbarrini G. Circadian variation in renal sodium and potassium handling in cirrhosis. The role of aldosterone, cortisol, sympathoadrenergic tone, and intratubular factors. Gastroenterology 1989; 96: 1187-98.
27. Kojama H, Tabata T, Nishzawa Y, Inoue T, Morii H, Yamaji T. Plasma endothelin levels in patients with uraemia. Lancet 1989; i: 991-2.
28. Gerbes AL, Møller S, Gülberg V, Henriksen JH. Endothelin-1 and -3 plasma concentrations in patients with cirrhosis of the liver. Role of splanchnic and renal passage and liver function. Hepatology, 1995; 21: 735-9.
29. Yanagisawa M, Masaki T. Endothelin, a novel endothelium-derived peptide. Biochem Pharmacol 1989; 38: 1877-83.
30. Yoshizawa T, Shinni O, Giaid A, Yanagisawa M, Gibson SJ, Kimura S, Uchiyama Y, Polak JM, Masaki T, Kanazawa I. Endothelin: a novel peptide in the posterior pituitary system. Science 1990; 247: 462-4.
31. Kaufmann H, Oribe E, Oliver J. Plasma endothelin during upright tilt: relevance for orthostatic hypotension? Lancet 1991; 338: 1542-5.
32. Guarner C, Soriano G, Tomas A, Bulbena O, Novella MT, Balanzo J, Vilardell F, Mourelle M, Moncada S. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 1993; 18: 1139-43.
33. Stark ME, Szurszewski. Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 1992; 103: 1928-49.
34. Shichiri M, Hirata Y, Ando K, Kanno K, Emori T, Ohta K, Marumo F. Postural change and volume expansion affect plasma endothelin levels. JAMA 1990; 263: 661 (letter).
35. Sugiura M, Inagami T, Kon V. Endotoxin stimulates endothelin release in vivo and in vitro as determined by radioimmunoassay. Biochem Biophys Res Commun 1989; 161: 1220-7.
36. Luscher TF, Boulanger CM, Dohi Y, Yang Z. Endothelium derived contracting factors. Hypertension 1992; 119: 117-30.
37. Kon V, Badr KF. Biological actions and pathophysiologic significance of endothelin in the kidney. Kidney Int 1991; 40: 1-12.
38. Badr KF, Murray JJ, Breyer MD, Takahashi K, Inagami T, Harris RC. Mesangial cells, glomerular and renal vascular responses to endothelin in the rat kidney: elucidation of signal transduction pathways. J Clin Invest 1989; 83: 336-42.
39. Lüscher TF, Bock HA, Yang Z, Diederich D. Endothelium-derived relaxing and contracting factors: perspectives in nephrology. Kidney Int 1991; 39: 575-90.
40. Perico N, Dadan J, Gabanelli M, Remuzzi G. Cyclo-oxygenase products and atrial natriuretic peptide modulate renal response to endothelin. J Pharmacol Exp Ther 1990; 252: 1213-20.
41. Anggard E, Galton S, Rae G, Thomas R, McLoughlin L, De Nucci G. The fate of radioiodinated endothelin-1 and endothelin-3 in the rat. J Cardiovasc Pharmacol 1989; 13 (Suppl 5): 46-9.
42. Miyauchi T, Sugishita Y, Yamaguchi Y, Ajisaka R, Tomizawa T, Onizuha M, Matsuda M, Kono I, Yanagisawa M, Goto K. Plasma concentrations of endothelin-1 and endothelin-3 are altered differently in various pathophysiological conditions in humans. J Cardiovasc Pharmacol 1991; 17 (Suppl 7): S394-7.
43. Skorecki KL, Brenner B. Body fluid homeostasis in congestive heart failure and cirrhosis with ascites. Am J Med 1982: 72: 323-38.
44. Jimenez W, Arroyo V. Pathogenesis of sodium retention in cirrhosis. J Hepatol 1993; 18: 147-50.
45. Gerbes AL. The role of atrial natriuretic peptide (ANP) in chronic liver disease. Pharmacol Ther 1993; 58: 53-76.