Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 1 36-1, 1997, Pages

  Rockey, Don C ^a   Chung, John J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bile duct ligation; Carbon tetrachloride; Cirrhosis; Cytokines; Endothelin; Hepatocyte; Kupffer cell; Nonparenchymal cell; Portal hypertension; Sinusoidal endothelial cell; Stellate cell; Wound healing

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME REGULATION; FIBROGENESIS; HISTOPATHOLOGY; LIVER FIBROSIS; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ANALYSIS;

EID: 0030822858     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.1.g124     Document Type: Article

References (31)

1. Bauer, M., N. C. Paquette, J. X. Zhang, I. Bauer, B. H. Pannen, S. R. Kleeberger, and M. G. Clemens. Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat. Hepatology 22: 1565-1576, 1995.
2. Belvisi, M., P. J. Barnes, S. Larkin, M. Yacoub, S. Tadjkarimi, T. J. Williams, and J. A. Mitchell. Nitric oxide synthase activity is elevated in inflammatory lung disease in humans. Eur. J. Pharmacol. 283: 255-258, 1995.
3. Billiar, T. R., R. D. Curran, F. K. Ferrari, D. L. Williams, and R. L. Simmons. Kupffer cell: hepatocyte cocultures release nitric oxide in response to bacterial endotoxin. J. Surg. Res. 48: 349-353, 1990.
4. Bissell, D. M., L. E. Hammaker, and U. A. Meyer. Parenchymal cells from adult rat liver in nonproliferating monolayer culture. I. Functional studies. J. Cell Biol. 59: 722-734, 1973.
5. Bredt, D. S., P. M. Hwang, C. E. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351: 714-718, 1991.
6. De Leeuw, A. M., S. P. McCarthy, A. Geerts, and D. L. Knook. Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 4: 392-403, 1984.
7. Friedman, S. L. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 328: 1828-1835, 1993.
8. Gupta, T. K., and R. J. Groszman. Administration of L-arginine, the physiological precursor of nitric oxide, reduces portal perfusion pressure and ameliorates hepatic hyperreactivity in experimental cirrhosis (Abstract). Hepatology 20: 200, 1994.
9. Harbrecht, B. G., T. R. Billiar, J. Stadler, A. J. Demetris, J. Ochoa, R. D. Curran, and R. L. Simmons. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J. Leukoc. Biol. 52: 390-394, 1992.
10. Heine, W. D. Proliferation kinetics of Kupffer cells. In: The Reticuloendothelial System and Pathogenesis of Liver Disease, edited by H. Liehr and M. Grun. Amsterdam: Elsevier, 1980, p. 27-44.
11. Hou, J., H. Kato, R. A. Cohen, A. V. Chobanian, and P. Brecher. Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 96: 2469-2477, 1995.
12. Irle, C., O. Kocher, and G. Gabbiani. Contractility of myofibroblasts during experimental liver cirrhosis. J. Submicrosc. Cytol. Pathol. 12: 209-217, 1980.
13. Jarnagin, W. R., D. C. Rockey, V. E. Koteliansky, S. S. Wang, and D. M. Bissell. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J. Cell Biol. 127: 2037-2048, 1994.
14. Kountouras, J., B. H. Billing, and P. J. Scheuer. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br. J. Exp. Pathol. 65: 305-311, 1984.
15. Lamas, S., P. A. Marsden, G. K. Li, P. Tempst, and T. Michel. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. USA 89: 6348-6352, 1992.
16. Laskin, D. L., D. E. Heck, C. R. Gardner, L. S. Feder, and J. D. Laskin. Distinct patterns of nitric oxide production in hepatic macrophages and endothelial cells following acute exposure of rats to endotoxin. J. Leukoc. Biol. 56: 751-758, 1994.
17. Lowenstein, C. J., C. S. Glatt, D. S. Bredt, and S. H. Snyder. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89: 6711-6715, 1992.
18. Moncada, S., and A. Higgs. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012, 1993.
19. Nathan, C., and Q. W. Xie. Nitric oxide syntheses: roles, tolls, and controls. Cell 78: 915-918, 1994.
20. Nishida, J., R. S. McCuskey, D. McDonnell, and E. S. Fox. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1135-G1141, 1994.
21. Nussler, A. K., M. Di Silvio, T. R. Billiar, R. A. Hoffman, D. A. Geller, R. Selby, J. Madariaga, and R. L. Simmons. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines, and endotoxin. J. Exp. Med. 176: 261-264, 1992.
22. Parks, R. W., W. D. Clements, M. G. Smye, C. Pope, B. J. Rowlands, and T. Diamond. Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage. Br. J. Surg. 83: 1345-1349, 1996.
23. Pitas, R. E., J. Boyles, R. W. Mahley, and D. M. Bissell. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J. Cell Biol. 100: 103-117, 1985.
24. Proctor, E., and K. Chatamra. High yield micronodular cirrhosis in the rat. Gastroenterology 83: 1183-1190, 1982.
25. Reynolds, J. V., P. Murchan, H. P. Redmond, R. W. Watson, N. Leonard, A. Hill, P. Clarke, P. Marks, F. B. Keane, and W. A. Tanner. Failure of macrophage activation in experimental obstructive jaundice: association with bacterial translocation. Br. J. Surg. 82: 534-538, 1995.
26. Rockey, D. C., and J. J. Chung. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J. Clin. Invest. 95: 1199-1206, 1995.
27. Rockey, D. C., and J. J. Chung. Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G260-G267, 1996.
28. Rockey, D. C., C. N. Housset, and S. L. Friedman. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J. Clin. Invest. 92: 1795-1804, 1993.
29. Spitzer, J. A. Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats. Hepatology 19: 217-228, 1994.
30. Sun, M. A., B. E. Wang, G. Annoni, S. D. Esposti, L. Biempica, and M. A. Zern. Two rat models of hepatic fibrosis. A morphologic and molecular comparison. Lab. Invest. 63: 467-475, 1990.
31. Whittle, B. J., and S. Moncada. Nitric oxide: the elusive mediator of the hyperdynamic circulation of cirrhosis? Hepatology 16: 1089-1092, 1992.