Activation of rat hepatic stellate cells in culture is associated with increased sensitivity to endothelin 1

Hepatology

Volumn 28, Issue 6, 1998, Pages 1566-1577

  Reinehr, Roland M ^a   Kubitz, Ralf ^a   Peters Regehr, Thorsten ^a   Bode, Johannes G ^a   Häussinger, Dieter ^a,b  

^a Medkinische Einrichtungen H HU   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; CALCIUM ION; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; PHENYLEPHRINE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CALCIUM BALANCE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL CULTURE; CELL TRANSFORMATION; FLUORESCENCE; IMMUNOCYTOCHEMISTRY; LIVER CELL; LIVER DISEASE; MALE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL;

EID: 0031737792     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280617     Document Type: Article

References (15)

1. Mathew J, Geerts A, Burt AD. Pathobiology of hepatic stellate cells. Hepatogastroenterology 1996;43:72-91.
2. Hautekeete ML, Geerts A. The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch 1997;430:195-207.
3. Geerts A, De Bleser P, Hautekeete ML, Niki T, Wisse E. Fat storing (Ito) cell biology. In: Arias IM, Boyer JL, Fausto N, eds. The Liver: Biology and Pathobiology. 3rd ed. New York: Raven, 1994:819-837.
4. Pinzani M. Hepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte. J Hepatol 1995;22:700-706.
5. Zhang JX, Bauer M, Clemens MG. Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver. Am J Physiol 1995;269: G269-G277.
6. Sakamoto M, Ueno T, Kin M, Ohira H, Torimura T, Inuzuka S, Sata M, et al. Ito cell contraction in response to endothelin-1 and substance P. HEPATOLOGY 1993;18:978-983.
7. Kawada N, Tran Thi TA, Klein H, Decker K. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur J Biochem 1993;213:815-823.
8. Okumura S, Takei Y, Kawano S, Nagano K, Masuda E, Goto M, Tsuji S, et al. Vasoactive effect of endothelin-1 on rat liver in vivo. HEPATOLOGY 1994;19:155-161.
9. Tanikawa K. Hepatic sinusoidal cells and sinusoidal circulation. J Gastroenterol Hepatol 1995;10(Suppl 1):S8-S11.
10. Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principle collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A 1985;82:8681-8685.
11. Gressner AM, Schäfer S. Comparison of sulphated glycosaminoglycan and hyaluronate synthesis and secretion in cultured hepatocytes, fat storing cells, and Kupffer cells. J Clin Chem Clin Biochem 1989;27:141-149.
12. Saperstein LA, Jirtle RL, Farouk M, Thompson HJ, Chung KS, Meyers WC. Transforming growth factor-beta 1 and mannose 6-phosphate/ insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. HEPATOLOGY 1994;19:412-417.
13. Rockey DC, Boyles JK, Gabbiani G, Friedman SL. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol 1992;24:193-203.
14. Friedman SL, Wei S, Blaner WS. Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF. Am J Physiol 1993;264:G947-G952.
15. Pinzani M, Gentilini P, Abboud HE. Phenotypical modulation of liver fat-storing cells by retinoids. Influence on unstimulated and growth factor-induced cell proliferation. J Hepatol 1992;14:211-220.