Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes

Journal of Virology

Volumn 76, Issue 13, 2002, Pages 6568-6576

  Gierynska, Malgorzata ^a   Kumaraguru, Uday ^a   Eo, Seong Kug ^a   Lee, Sujin ^a   Krieg, Arthur ^a   Rouse, Barry T ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; GLYCOPROTEIN B; IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE GLYCOPROTEIN B COMPLEX; TETRAMER; UNCLASSIFIED DRUG;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SPECIFICITY; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; IMMUNIZATION; IMMUNOLOGICAL MEMORY; IMMUNOSTIMULATION; INFECTION PREVENTION; LYMPHOCYTE COUNT; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VACCINIA VIRUS; VIRUS RECOMBINANT;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DINUCLEOSIDE PHOSPHATES; FEMALE; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HERPESVIRUS VACCINES; IMMUNITY, MUCOSAL; IMMUNODOMINANT EPITOPES; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; PEPTIDES; VACCINATION; VAGINA; VIRAL ENVELOPE PROTEINS;

EID: 0036284414     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.13.6568-6576.2002     Document Type: Article

References (38)

1. Induction NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
2. + dendritic cells
3. Human TLR9 confers responsiveness to bacterial DNA via species-spiceific CpG motif recognition
4. Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity
5. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
6. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
7. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
8. DNA vaccines: Immunology, application, and optimization
9. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
10. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
11. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
12. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
13. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
14. CD8 CTL from genital herpes simplex lesions: Recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells
15. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
16. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
17. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
18. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
19. CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses
20. Roles of different T-cell subsets in control of herpes simplex virus infection determined by using T-cell-deficient mouse models
21. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences
22. The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens
23. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
24. Different roles for L3T4+ and Lyt 2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system
25. CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines
26. Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes
27. + cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes
28. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
29. The role of T cell immunity in control of herpes simplex virus
30. Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: Implications for the fate of vitally infected neurons
31. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
32. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins
33. DNA as an adjuvant: Capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen
34. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity
35. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses
36. The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant
37. + T cell dependent
38. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis