CD8 CTL from genital herpes simplex lesions: Recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 4049-4058

  Koelle, D M ^a   Chen, H B ^a   Gavin, M A ^a   Wald, A ^a   Kwok, W W ^a   Corey, L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; IMMEDIATE EARLY PROTEIN; VIRUS ANTIGEN; VIRUS DNA;

ANTIGEN RECOGNITION; ARTICLE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; GENE EXPRESSION; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; INTEGUMENT; MOLECULAR CLONING; PRIORITY JOURNAL; SKIN CELL; VACCINE PRODUCTION; VIRUS INHIBITION;

EID: 0035869533     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.4049     Document Type: Article

References (86)

1. Herpes simplex viruses and their replication
2. Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: Implications for the fate of virally infected neurons
3. Cell surface expression of H2 antigens on primary sensory neurons in response to acute but not latent herpes simplex virus infection in vivo
4. + cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice
5. + T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons
6. Reactivation of genital herpes type 2 infection in asymptomatic seropositive persons
7. Evasion and obstruction: The central strategy of the interaction between human herpesviruses with host defense
8. Viral strategies of immune evasion
9. Herpesvirus evasion of the immune system
10. + cytotoxic T lymphocytes
11. Direct recovery of HSV-specific T lymphocyte clones from human recurrent HSV-2 lesions
12. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
13. + cytotoxic T lymphocyte responses
14. Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP
15. + CTL clones recognize HSV-2-infected fibroblasts after treatment with IFN-γ or when virion host shutoff functions are disabled
16. Evolution of recurrent herpes simplex lesions: An immunohistologic study
17. + herpes simplex virus-specific cytotoxic T lymphocyte clones recognize diverse virion protein antigens
18. Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-γ and IL-12 production
19. Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression
20. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens
21. Impaired assembly and transport of HLA-A and -B antigens in a TxB hybrid
22. SV40-transformed simian cells support the replication of early SV40 mutants
23. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunoblot for detecting antibodies to herpes simplex types 1 and 2 in human sera
24. Direct demonstration of the clonogenic potential of every human peripheral blood T cell
25. In vivo migration and function of transferred HlV-1-specific cytotoxic T cells
26. Pathogenesis of herpes simplex virus in cultures of epidermal cells from subjects with frequent recurrences
27. Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine kinase gene
28. The genome sequence of herpes simplex virus type 2
29. Cell culture procedures for diagnostic virology
30. Mutants defective in herpes simplex virus type 2 ICP4: Isolation and preliminary characterization
31. + T cells
32. Cloning of genes coding for antigens recognized by cytolytic T lymphocytes
33. Preparation of HSV-DNA and production of infectious virus
34. Single step RNA isolation from cultured cells or tissues
35. Tegument-specific, virus-reactive CD4 T-cells localize to the cornea in herpes simplex virus interstitial keratitis in humans
36. CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: Comparison with responses to tegument and envelope glycoproteins
37. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis
38. A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17
39. + CTL clones derived from genital lesions
40. Interpolated Marker chains for eukaryotic promoter recognition
41. Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions
42. Differences in the intracellular localization and fate of herpes simplex virus tegument proteins early in the infection of vero cells
43. The complete DNA sequence of the long unique region of herpes simplex virus type I
44. Stable ubiquination of the ICP0R protein of herpes simplex virus type I during productive infection
45. Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron mRNAs of the herpes simplex virus 1 regulatory gene α0 accumulate in the cytoplasm of infected cells
46. Overlapping peptides of melanocyte differentiation antigen melan-A/mart01 recognized by autologous cytolytic T lymphocytes in association with HLA-B45.1 and HLA A-A2.1
47. Cytotoxic T-lymphocyte responses to HIV-I reverse transcriptase
48. HLA supertypes and supermotifs: A functional perspective on HLA polymorphism
49. Genital Herpes
50. Prospects for control of herpes simplex virus disease through immunization
51. Two double-blind, placebo-controlled trials of a vaccine containing recombinant gD2 and gB2 antigens in MF59 adjuvant for the prevention of genital HSV-2 acquisition
52. Gender-specific efficacy of a prophylactic SBAS4-adjuvanted gD2 subunit vaccine against genital herpes disease (GHD): Results of two clinical efficacy trials
53. Recovery of antigen-specific T-cells from the uterine cervix of women with genital herpes simplex virus type 2 virus infection
54. Immunization with a single major histocompatibility class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity
55. Characterization of a diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential Vβ bias
56. + T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection
57. High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes
58. Acquisition of symptomatic and asymptomatic HSV-1 and HSV-2 infections: A prospective study of their incidence and clinical spectrum
59. Antigenic analysis of a major neutralization site of herpes simplex virus glyoprotein D, using deletion mutants and monoclonal antibody-resistant mutants
60. + T cell clones recovered from recurrent genital HSV-2 lesions
61. + T cells by dendritic cells
62. Peptide binding affinity and the generation of HSV-1 specific cytotoxic CD8 lymphocytes
63. Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-γ
64. T-cell mediated rejection of gene modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
65. Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35)
66. Herpes simplex virus turns off the TAP to evade host immunity
67. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product
68. The human cytotoxic T-lymphocyte (CLT) response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T-cell receptor usage of pp65-specific CTL
69. + T cell response to human cytomegalovirus: The 72-kilodalton major immediate early protein revisited
70. Identification and characterization of the virion protein products of herpes simplex type 1 gene UL47
71. Role of herpes simplex virus type 1 UL46 and UL47 in αTIF-mediated transcriptional induction: Characterization of three viral deletion mutants
72. Identification of three genes nonessential for growth in cell culture near the right terminus of the unique sequences of long component of herpes simplex virus type 1
73. ICP0, a regulator of herpes simplex virus during lytic and latent infection
74. Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1
75. Human peptide transporter deficiency: Importance of HLA-B in the presentation of TAP-independent EBV antigens
76. Sequential cleavage by metallopeptidases and proteosomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen processing
77. An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S
78. Herpes simplex virus type 1 glycoproteins gB, gC, and gD are major targets for CD4 T-lymphocyte cytotoxicity in HLA-DR expressing human epidermal keratinocytes
79. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines and activated cytolytic T cells
80. Significance of local γ interferon in recurrent herpes simplex infection
81. Intraocular T cells of patients with herpes simplex (HSV)-induced acute retinal necrosis recognize HSV tegument proteins VP11/12 and VP13/14
82. Cytoplasm-to-nucleus translocation of a herpesvirus tegument protein during cell division
83. Intercellular trafficking of VP22-GFP fusion proteins
84. Intercellular delivery of the thymidine kinase prodrug activating enzyme by the herpes simplex virus protein VP22
85. Analysis of the basal and inducible activities of the ICP0 promoter of herpes simplex virus type 1