Time course of nitric oxide, peroxynitrite, and antioxidants in the endotoxemic heart

Critical Care Medicine

Volumn 30, Issue 6, 2002, Pages 1291-1296

  Iqbal, Mobeen ^a   Cohen, Rubin I ^a   Marzouk, Kamel ^a   Shu, Fang Liu ^a  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Glutathione; Lipopolysaccharide; Myocardial function; Nitric oxide; Oxidative stress; Peroxynitrite

Indexed keywords

3 NITROTYROSINE; ANTIOXIDANT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OXYGEN RADICAL; PEROXYNITRITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL INTERACTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTOXEMIA; ENZYME ACTIVITY; HEART LEFT VENTRICLE CONTRACTILITY; HEART PAPILLARY MUSCLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TIME;

EID: 0036276883     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200206000-00021     Document Type: Article

References (33)

1. Nitric oxide and septic shock
2. Nitric oxide and cardiac function
3. Negative inotropic effects of cytokines on the heart mediated by nitric oxide
4. Nitric oxide synthase inhibition partially prevents decreased LV contractility during endotoxemia
5. Effects of nitric oxide donor SIN-1 on oxygen availability and regional blood flow during endotoxic shock
6. Inhaled nitric oxide prevents left ventricular impairment during endotoxemia
7. Selective NOS inhibition restores myocardial contractility in endotoxemic rats; however, myocardial NO content does not correlate with myocardial dysfunction
8. L-2-Oxothiazolidine-4carboxylic acid prevents endotoxin-induced cardiac dysfunction
9. Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure
10. Peroxynitrite contributes to spontaneous loss of cardiac efficiency in isolated working rat hearts
11. Influence of nitric oxide on the intracellular reduced glutathione pool: Different cellular capacities and strategies to encounter nitric oxide-mediated stress
12. Induction of nitric oxide synthesis in J774 cells lowers intracellular glutathione: Effect of modulated glutathione redox status on nitric oxide synthase induction
13. Porcine endotoxemic shock is associated with increased expired nitric oxide
14. Physiological chemistry of nitric oxide and its metabolites: Implications in inflammation
15. Effect of nitric oxide synthase inhibition on myocardial contractility in anesthetized and normal dogs
16. Status of myocardial antioxidants in ischemia-reperfusion injury
17. Inactivation of glutathione peroxidase by nitric oxide: Implication for cytotoxicity
18. Development of myocardial dysfunction in endotoxin shock
19. Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo
20. Activities of conjugating and antioxidant enzymes following endotoxin exposure
21. Nitric oxide: Novel biology with clinical relevance
22. Nitric oxide inhibits peroxide-mediated endothelial toxicity
23. Redox signaling: Nitrosylation and related target interactions of nitric oxide
24. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
25. Endotoxin stimulates gene expression of ROS-eliminating pathways in rat hepatic endothelial and Kupffer cells
26. Dynamic aspects of glutathione and nitric oxide metabolism in endotoxemic rats
27. Cellular responses to nitric oxide: Role of protein s-thiolation/dethiolation
28. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
29. Unraveling peroxynitrite formation in biological systems
30. What nitrates tyrosine? Is nitro-tyrosine specific as a biomarker of peroxynitrite formation in vivo?
31. Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
32. Glutathione peroxidase protects against peroxynitrite-mediated oxidation: A new function for selenoproteins as peroxynitrite reductase
33. Glutathione-dependent regulation of nitric oxide production in isolated rat hepatocyte suspensions