Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of γ-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure

British Journal of Pharmacology

Volumn 123, Issue 3, 1998, Pages 525-537

  Cuzzocrea, Salvatore ^a   Zingarelli, Basilia ^a   O'Connor, Michael ^a   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Endothelium; Endothelium derived factors; Free radicals; Shock

Indexed keywords

2,4 DINITROPHENYLHYDRAZINE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETYLCHOLINE; BACTERIUM LIPOPOLYSACCHARIDE; BUTHIONINE SULFOXIMINE; FORMAZAN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NORADRENALIN; NUCLEAR PROTEIN; PEROXYNITRITE; SINGLE STRANDED DNA;

ANIMAL CELL; AORTA MEDIA; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; ENDOTHELIUM INJURY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; MITOCHONDRIAL RESPIRATION; MUSCLE INJURY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; THORACIC AORTA; UMBILICAL VEIN; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA, THORACIC; BUTHIONINE SULFOXIMINE; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; ENZYME INHIBITORS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; MUSCLE CONTRACTION; NITRATES; NITRIC OXIDE SYNTHASE; RATS; SHOCK, SEPTIC;

EID: 0031985249     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701612     Document Type: Article

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