Peroxynitrite contributes to spontaneous loss of cardiac efficiency in isolated working rat hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 276, Issue 6 45-6, 1999, Pages

  Ferdinandy, Peter ^a   Panas, Donna ^a   Schulz, Richard ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cardiac function; Cycloheximide; Energy metabolism; Inducible nitric oxide synthase; Xanthine oxidase

Indexed keywords

NITRIC OXIDE SYNTHASE; PEROXYNITRITE; XANTHINE OXIDASE;

ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; ENERGY METABOLISM; ENZYME ACTIVITY; HEART FUNCTION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE OXYGEN CONSUMPTION; HEART WORK; MALE; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; RAT;

EID: 0033001511     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.6.h1861     Document Type: Article

References (37)

1. Ally, A., and G. Park. Rapid determination of creatine, phosphocreatine, purine bases and nucleotides (ATP, ADP, AMP, GTP, GDP) in heart biopsies by gradient ion-pair reversed-phase liquid chromatography. J. Chromatogr. 575: 19-27, 1992.
2. Balligand, J. L., D. Ungureanu-Longrois, W. W. Simmons, L. Kobzik, C. J. Lowenstein, S. Lamas, R. A. Kelly, T. W. Smith, and T. Michel. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1293-H1303, 1995.
3. Balligand, J. L., D. Ungureanu-Longrois, W. W. Simmons, D. Pimental, T. A. Malinski, M. Kapturczak, Z. Taha, C. J. Lowenstein, A. J. Davidof, R. A. Kelly, T. W. Smith, and T. Michel. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization, and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J. Biol. Chem. 269: 27580-27588, 1994.
4. Becker, B. F., N. Reinholz, T. Ozcelik, B. Leipert, and E. Gerlach. Uric acid as radical scavenger and antioxidant in the heart. Pflügers Arch. 415: 127-135, 1989.
5. Beckman, J. S., and W. H. Koppenol. Nitric oxide, Superoxide, and peroxynitrite: the good, the bad and the ugly. Am. J. Physiol. 271 (Cell Physiol. 40): C1424-C1437, 1996.
6. Beckman, J. S., D. A. Parks, J. D. Pearson, P. A. Marshall, and B. A. Freeman. A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Free Radic. Biol. Med. 6: 607-615, 1989.
7. Davies, N. J., J. J. McVeigh, and G. D. Lopaschuk. Effect of TA-3090, a new calcium channel blocker, on myocardial substrate utilization in ischemic and nonischemic isolated working fatty acid-perfused rat hearts. Circ. Res. 68: 807-817, 1991.
8. Dupont, G. P., T. P. Huecksteadt, B. C. Marshall, U. S. Ryan, J. R. Michael, and J. R. Hoidal. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J. Clin. Invest. 89: 197-202, 1992.
9. Ferdinandy, P., T. Csont, C. Csonka, M. Török, M. Dux, J. Nemeth, L. I. Horvath, L. Dux, Z. Szilvassy, and G. Jancso. Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP? Naunyn Schmiedebergs Arch. Pharmacol. 356: 356-363, 1997.
10. ATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide. Cardiovasc. Res. 30: 781-787, 1995.
11. Flanders, K. C., A. R Bhandiwad, and T. S. Winokur. Transforming growth factor-beta blocks cytokine induction of catalase and xanthine oxidase mRNA levels in cultured rat cardiac cells. J. Mol. Cell. Cardiol. 29: 273-280, 1997.
12. Furchgott, R. F., and T. de Gubareff. The high energy phosphate content of cardiac muscle under various experimental conditions which alter contractile strength. J. Pharmacol. Exp. Ther. 124: 203-218, 1958.
13. Hille, R., and T. Nishino. Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J. 9: 995-1003, 1995.
14. Ishida, H., K. Ichimori, Y. Hirota, M. Fukahori, and H. Nakazawa. Peroxynitrite-induced cardiac myocyte injury. Free Radic. Biol. Med. 20: 343-350, 1996.
15. Kamikubo, Y. Cardiac dysfunction and endogenous cytokines in global ischemia and reperfusion injury. Hokkaido Igaku Zasshi 68: 813-826, 1993. (In Japanese.)
16. Klemm, P., T. D. Warner, T. Hohlfeld, R. Corder, and J. R. Vane. Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines. Proc. Natl. Acad. Sci. USA 92: 2691-2695, 1995.
17. Kloner, R. A., K. Przyklenk, and P. Whittaker. Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues. Circulation 80: 1115-1127, 1989.
18. O2 during reperfusion of ischemic hearts. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H72-H80, 1996.
19. Liu, P. T., C. E. Hock, R. Nagele, and P. Y. K. Wong. Formation of nitric oxide, Superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H2327-H2336, 1997.
20. Lopaschuk, G. D., R. Barr, and R. Wambolt. Effects of diltiazem on glycolysis and oxidative metabolism in the ischemic and ischemic/reperfused heart. J. Pharmacol. Exp. Ther. 260: 1220-1228, 1992.
21. Neely, J. R., H. Liebermeister, E. J. Battersby, and H. E. Morgan. Effect of pressure development on oxygen consumption by isolated rat heart. Am. J. Physiol. 212: 804-814, 1967.
22. Opie, L. H., K. R. L. Mansford, and P. Owen. Effects of increased heart work on glycolysis and adenine nucleotides in the perfused heart of normal and diabetic rats. Biochem. J. 124: 475-490, 1971.
23. Rubbo, H., V. Darley-Usmar, and B. A. Freeman. Nitric oxide regulation of tissue free radical injury. Chem. Res. Toxicol. 9: 809-820, 1996.
24. Schulz, R., K. L. Dodge, G. D. Lopaschuk, and A. S. Clanachan. Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1212-H1219, 1997.
25. 2+-independent nitric oxide synthase in the myocardium. Br. J. Pharmacol. 105: 575-580, 1992.
26. Schulz, R., D. L. Panas, R. Catena, S. Moncada, P. M. Olley, and G. D. Lopaschuk. The role of nitric oxide in cardiac depression induced by interleukin-1β and tumor necrosis factor-α. Br. J. Pharmacol. 114: 27-34, 1995.
27. Schulz, R., and C. R. Triggle. Role of NO in vascular smooth muscle and cardiac muscle function. Trends Pharmacol. Sci. 15: 255-259, 1994.
28. Smith, J. A., M. W. Radomski, R. Schulz, S. Moncada, and M. J. Lewis. Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase. Br. J. Pharmacol. 108: 1107-1110, 1993.
29. Stanley, W. C., G. D. Lopaschuk, J. L. Hall, and J. G. McCormack. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions. Cardiovasc. Res. 33: 243-257, 1997.
30. Szabo, C. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6: 79-88, 1996.
31. Szabo, C., B. Zingarelli, and A. L. Salzman. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ. Res. 78: 1051-1063, 1996.
32. Taegtmeyer, H., R. Hems, and H. A. Krebs. Utilization of energy providing substrates in the isolated working rat heart. Biochem. J. 186: 701-711, 1980.
33. Van der Vliet, A., J. P. Eiserich, C. A. Neill, B. Halliwell, and C. E. Cross. Tyrosine modification by reactive nitrogen species: a closer look. Arch. Biochem. Biophys. 329: 341-349, 1995.
34. Xie, Y. W., and M. S. Wolin. Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Involvement in response to hypoxia/ reoxygenation. Circulation 94: 2580-2586, 1996.
35. Yasmin, W., K. D. Strynadka, and R. Schulz. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc. Res. 33: 422-432, 1997.
36. 2+ in cardiac myocytes. Circ. Res. 81: 1011-1020, 1997.
37. Zingarelli, B., B. J. Day, J. D. Crapo, A. L. Salzman, and C. Szabo. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxin shock. Br. J. Pharmacol. 120: 259-267, 1997.